gc-1-compound and Nerve-Degeneration

gc-1-compound has been researched along with Nerve-Degeneration* in 1 studies

Other Studies

1 other study(ies) available for gc-1-compound and Nerve-Degeneration

ArticleYear
Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE.
    Journal of neuroimmunology, 2021, 03-15, Volume: 352

    We have previously demonstrated that thyromimetics stimulate oligodendrocyte precursor cell differentiation and promote remyelination in murine demyelination models. We investigated whether a thyroid receptor-beta selective thyromimetic, sobetirome (Sob), and its CNS-targeted prodrug, Sob-AM2, could prevent myelin and axonal degeneration in experimental autoimmune encephalomyelitis (EAE). Compared to controls, EAE mice receiving triiodothyronine (T3, 0.4 mg/kg), Sob (5 mg/kg) or Sob-AM2 (5 mg/kg) had reduced clinical disease and, within the spinal cord, less tissue damage, more normally myelinated axons, fewer degenerating axons and more oligodendrocytes. T3 and Sob also protected cultured oligodendrocytes against cell death. Thyromimetics thus might protect against oligodendrocyte death, demyelination and axonal degeneration as well as stimulate remyelination in multiple sclerosis.

    Topics: Acetates; Animals; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Degeneration; Oligodendroglia; Phenols; Prodrugs; Triiodothyronine

2021