gbr 12935 has been researched along with Schizophrenia in 4 studies
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine : An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| " [3H]GBR 12935 binding constants were calculated by Scatchard analysis from the autopsied brains from 29 individuals with schizophrenia, and 28 control subjects." | 3.69 | Age-related changes in [3H]GBR 12935 binding site density in the prefrontal cortex of controls and schizophrenics. ( Casanova, MF; Hitri, A; Kleinman, JE; Weinberger, DR; Wyatt, RJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hitri, A | 1 |
| Casanova, MF | 1 |
| Kleinman, JE | 1 |
| Weinberger, DR | 1 |
| Wyatt, RJ | 1 |
| Pearce, RK | 1 |
| Seeman, P | 1 |
| Jellinger, K | 1 |
| Tourtellotte, WW | 1 |
| Czudek, C | 1 |
| Reynolds, GP | 1 |
| Hirai, M | 1 |
| Kitamura, N | 1 |
| Hashimoto, T | 1 |
| Nakai, T | 1 |
| Mita, T | 1 |
| Shirakawa, O | 1 |
| Yamadori, T | 1 |
| Amano, T | 1 |
| Noguchi-Kuno, SA | 1 |
| Tanaka, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| I-123 Beta-CIT SPECT Studies of Dopamine and Serotonin Transporters in Neuropsychiatric Patients and Normal Volunteers[NCT00001771] | 112 participants | Observational | 1998-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for gbr 12935 and Schizophrenia
| Article | Year |
|---|---|
Age-related changes in [3H]GBR 12935 binding site density in the prefrontal cortex of controls and schizophrenics.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Carrier Proteins; Dopamine Plasma Membrane Transport Pr | 1995 |
Dopamine uptake sites and dopamine receptors in Parkinson's disease and schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Binding Sites; Dopamine; Female; Humans; Levodopa; Ligands; Male; Mi | 1990 |
[3H] GBR 12935 binding to the dopamine uptake site in post-mortem brain tissue in schizophrenia.
Topics: Aged; Amygdala; Brain Chemistry; Caudate Nucleus; Female; Humans; Male; Piperazines; Receptors, Dopa | 1989 |
[3H]GBR-12935 binding sites in human striatal membranes: binding characteristics and changes in parkinsonians and schizophrenics.
Topics: Aged; Animals; Binding Sites; Binding, Competitive; Corpus Striatum; Female; Humans; In Vitro Techni | 1988 |