Page last updated: 2024-10-27

gbr 12935 and Neuroblastoma

gbr 12935 has been researched along with Neuroblastoma in 2 studies

1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine : An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Watabe, M1
Nakaki, T1
Koutsilieri, E1
Kornhuber, J1
Degen, HJ1
Lesch, KP1
Sopper, S1
ter Meulen, V1
Riederer, P1

Other Studies

2 other studies available for gbr 12935 and Neuroblastoma

ArticleYear
Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells.
    Molecular pharmacology, 2008, Volume: 74, Issue:4

    Topics: Apoptosis; Cell Line, Tumor; Cytosol; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug;

2008
U-373 MG glioblastoma and IMR-32 neuroblastoma cell lines express the dopamine and vesicular monoamine transporters.
    Journal of neuroscience research, 1996, Aug-01, Volume: 45, Issue:3

    Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line; Dopamine; Dopamine Plasma Membrane Transport

1996