gbr 12935 has been researched along with Alzheimer Disease in 2 studies
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine : An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allard, PO | 1 |
| Rinne, J | 1 |
| Marcusson, JO | 2 |
| Allard, P | 1 |
| Alafuzoff, I | 1 |
| Carlsson, A | 1 |
| Eriksson, K | 1 |
| Ericson, E | 1 |
| Gottfries, CG | 1 |
2 other studies available for gbr 12935 and Alzheimer Disease
| Article | Year |
|---|---|
Dopamine uptake sites in Parkinson's disease and in dementia of the Alzheimer type.
Topics: Aged; Alzheimer Disease; Humans; Ligands; Parkinson Disease; Piperazines; Putamen; Receptors, Dopami | 1994 |
Loss of dopamine uptake sites labeled with [3H]GBR-12935 in Alzheimer's disease.
Topics: Aged; alpha-Methyltyrosine; Alzheimer Disease; Dopamine; Female; Homovanillic Acid; Humans; In Vitro | 1990 |