gbr 12935 has been researched along with Absence Seizure in 3 studies
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine : An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice." | 3.72 | Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. ( Arai, S; Dohi, T; Kihira, K; Kitayama, S; Kumagai, K; Kumagai, M; Morita, K, 2003) |
| "Benztropine (Cogentin) is an antiparkinson agent that has limited abuse despite its ability to block dopamine uptake, and has been suggested as a candidate for the treatment of cocaine dependence." | 1.29 | Effects of benztropine on behavioral and toxic effects of cocaine: comparison with atropine and the selective dopamine uptake inhibitor 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)-piperazine. ( Acri, JB; Siedleck, BK; Witkin, JM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arai, S | 1 |
| Morita, K | 2 |
| Kitayama, S | 2 |
| Kumagai, K | 1 |
| Kumagai, M | 1 |
| Kihira, K | 1 |
| Dohi, T | 2 |
| Acri, JB | 1 |
| Siedleck, BK | 1 |
| Witkin, JM | 1 |
| Sato, T | 1 |
| Ikeda, T | 1 |
3 other studies available for gbr 12935 and Absence Seizure
| Article | Year |
|---|---|
Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics.
Topics: Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Brain; Brain Chemistry; Citalopram; Cocai | 2003 |
Effects of benztropine on behavioral and toxic effects of cocaine: comparison with atropine and the selective dopamine uptake inhibitor 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)-piperazine.
Topics: Animals; Atropine; Behavior, Animal; Benztropine; Cocaine; Discrimination Learning; Dopamine Uptake | 1996 |
Changes in seizure susceptibility to local anesthetics by repeated administration of cocaine and nomifensine but not GBR12935: possible involvement of noradrenergic system.
Topics: Anesthetics, Local; Animals; Cocaine; Male; Mice; Mice, Inbred ICR; Nomifensine; Norepinephrine; Pip | 2000 |