gavestinel and Brain-Ischemia

gavestinel has been researched along with Brain-Ischemia* in 1 studies

Other Studies

1 other study(ies) available for gavestinel and Brain-Ischemia

Article	Year
Enantiomerically pure tetrahydroquinoline derivatives as in vivo potent antagonists of the glycine binding site associated to the NMDA receptor. Bioorganic & medicinal chemistry letters, 2003, Nov-03, Volume: 13, Issue:21 To identify neuroprotective agents after stroke, new substituted tetrahydroquinoline derivatives were designed as antagonists of the glycine binding site associated to the NMDA receptor, satisfying the key pharmacophoric requirements. In particular, the racemate 3c exhibited outstanding in vivo activity in the MCAo model in rats, when given iv both pre- and post-ischemia. Pure enantiomers 3c-(+) and 3c-(-) have been prepared following an original synthetic route. Despite the significant difference of activity observed in vitro, they shown similar neuroprotective profile in the MCAo model in rats. Topics: Animals; Binding Sites; Brain Ischemia; Dose-Response Relationship, Drug; Injections, Intravenous; Middle Cerebral Artery; Molecular Conformation; Neuroprotective Agents; Quinolines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Stereoisomerism	2003

Article

Year

Enantiomerically pure tetrahydroquinoline derivatives as in vivo potent antagonists of the glycine binding site associated to the NMDA receptor.

Bioorganic & medicinal chemistry letters, 2003, Nov-03, Volume: 13, Issue:21

To identify neuroprotective agents after stroke, new substituted tetrahydroquinoline derivatives were designed as antagonists of the glycine binding site associated to the NMDA receptor, satisfying the key pharmacophoric requirements. In particular, the racemate 3c exhibited outstanding in vivo activity in the MCAo model in rats, when given iv both pre- and post-ischemia. Pure enantiomers 3c-(+) and 3c-(-) have been prepared following an original synthetic route. Despite the significant difference of activity observed in vitro, they shown similar neuroprotective profile in the MCAo model in rats.

Topics: Animals; Binding Sites; Brain Ischemia; Dose-Response Relationship, Drug; Injections, Intravenous; Middle Cerebral Artery; Molecular Conformation; Neuroprotective Agents; Quinolines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Stereoisomerism

2003