gatifloxacin has been researched along with Sensitivity and Specificity in 21 studies
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.
gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The validated method was applied to assay real plasma samples used for pharmacokinetic studies and therapeutic drug monitoring of the selected drugs." | 1.39 | Simultaneous quantification of linezolid, tinidazole, norfloxacin, moxifloxacin, levofloxacin, and gatifloxacin in human plasma for therapeutic drug monitoring and pharmacokinetic studies in human volunteers. ( Helmy, SA, 2013) |
| " The developed assay method was applied to a pharmacokinetic study in human volunteers following oral administration of 400 mg GFC tablet." | 1.35 | Development and validation of a HPLC method for simultaneous quantitation of gatifloxacin, sparfloxacin and moxifloxacin using levofloxacin as internal standard in human plasma: application to a clinical pharmacokinetic study. ( Mullangi, R; Narasu, L; Shankar, BP; Srinivas, N, 2008) |
| " The method is successfully used for the estimation of gatifloxacin in a variety of dosage forms, and the results are in good agreement with the label claims." | 1.34 | Development and validation of an ion-pairing RP-HPLC method for the estimation of gatifloxacin in bulk and formulations. ( Bende, G; Saha, R; Snehalatha, M; Venugopal, K, 2007) |
| "A simple and sensitive high-performance thin-layer chromatography (HPTLC) method has been developed for the quantitative estimation of gatifloxacin and ornidazole in its combined dosage forms." | 1.33 | Determination of gatifloxacin and ornidazole in tablet dosage forms by high-performance thin-layer chromatography. ( Marolia, BP; Patel, HM; Rathod, IS; Shah, DR; Shah, SA; Suhagia, BN, 2006) |
| "Gatifloxacin is an advanced-generation, 8-methoxyfluoroquinolone that is active against a broad spectrum of pathogens, including antiobiotic resistant Streptococcus pneumoniae." | 1.31 | Determination of gatifloxacin in human plasma by liquid chromatography/electrospray tandem mass spectrometry. ( Bartlett, MG; Stewart, JT; Vishwanathan, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (76.19) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Helmy, SA | 1 |
| Lima Vaz, MF | 1 |
| de Oliveira, JV | 1 |
| Cassella, RJ | 1 |
| Pacheco, WF | 1 |
| Srinivas, N | 1 |
| Narasu, L | 1 |
| Shankar, BP | 1 |
| Mullangi, R | 1 |
| Fang, PF | 1 |
| Cai, HL | 1 |
| Li, HD | 1 |
| Zhu, RH | 1 |
| Tan, QY | 1 |
| Gao, W | 1 |
| Xu, P | 1 |
| Liu, YP | 1 |
| Zhang, WY | 1 |
| Chen, YC | 1 |
| Zhang, F | 1 |
| Davis, LT | 1 |
| Kumar, N | 1 |
| Nijm, LM | 1 |
| Ulanski, LJ | 1 |
| Tu, EY | 1 |
| Fiscella, RG | 1 |
| Peterson, RJ | 1 |
| Glickman, RD | 1 |
| Xiao, D | 1 |
| Dramou, P | 1 |
| Xiong, N | 1 |
| He, H | 1 |
| Li, H | 1 |
| Yuan, D | 1 |
| Dai, H | 1 |
| Pendland, SL | 1 |
| Neuhauser, MM | 1 |
| Garey, KW | 1 |
| Prause, JL | 1 |
| Jung, R | 1 |
| Pfaller, MA | 1 |
| Jones, RN | 2 |
| Anderegg, TR | 1 |
| Biedenbach, DJ | 1 |
| Overholser, BR | 1 |
| Kays, MB | 1 |
| Sowinski, KM | 1 |
| Garrison, MW | 1 |
| Schimmels, JA | 1 |
| Madaras-Kelly, KJ | 1 |
| Ngan, CC | 1 |
| Lim, T | 1 |
| Choo, CM | 1 |
| Toh, GL | 1 |
| Lim, YS | 1 |
| Ocaña, JA | 1 |
| Barragán, FJ | 1 |
| Callejón, M | 1 |
| Sulochana, S | 1 |
| Rahman, F | 1 |
| Paramasivan, CN | 1 |
| Santoro, MI | 1 |
| Kassab, NM | 1 |
| Singh, AK | 1 |
| Kedor-Hackmam, ER | 1 |
| Suhagia, BN | 1 |
| Shah, SA | 1 |
| Rathod, IS | 1 |
| Patel, HM | 1 |
| Shah, DR | 1 |
| Marolia, BP | 1 |
| Sultana, N | 1 |
| Arayne, MS | 1 |
| Naz, A | 1 |
| Tasso, L | 1 |
| Dalla Costa, T | 1 |
| Venugopal, K | 1 |
| Snehalatha, M | 1 |
| Bende, G | 1 |
| Saha, R | 1 |
| Vishwanathan, K | 1 |
| Bartlett, MG | 1 |
| Stewart, JT | 1 |
| Leroi, MJ | 1 |
| Siarakas, S | 1 |
| Gottlieb, T | 1 |
1 trial available for gatifloxacin and Sensitivity and Specificity
| Article | Year |
|---|---|
Gatifloxacin phase IV surveillance trial (TeqCES study) utilizing 5000 primary care physician practices: report of pathogens isolated and susceptibility patterns in community-acquired respiratory tract infections.
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Community-Acquired Infections; Drug Resis | 2002 |
20 other studies available for gatifloxacin and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous quantification of linezolid, tinidazole, norfloxacin, moxifloxacin, levofloxacin, and gatifloxacin in human plasma for therapeutic drug monitoring and pharmacokinetic studies in human volunteers.
Topics: Acetamides; Adult; Anti-Infective Agents; Aza Compounds; Chromatography, High Pressure Liquid; Drug | 2013 |
Development of a flow-injection analysis system with fluorescence detection for gatifloxacin determination in organized medium.
Topics: Chromatography, High Pressure Liquid; Equipment Design; Flow Injection Analysis; Fluoroquinolones; G | 2015 |
Development and validation of a HPLC method for simultaneous quantitation of gatifloxacin, sparfloxacin and moxifloxacin using levofloxacin as internal standard in human plasma: application to a clinical pharmacokinetic study.
Topics: Administration, Oral; Analytic Sample Preparation Methods; Aza Compounds; Chromatography, High Press | 2008 |
Simultaneous determination of isoniazid, rifampicin, levofloxacin in mouse tissues and plasma by high performance liquid chromatography-tandem mass spectrometry.
Topics: Animals; Antibiotics, Antitubercular; Brain Chemistry; Chromatography, High Pressure Liquid; Female; | 2010 |
An adaptable HPLC method for the analysis of frequently used antibiotics in ocular samples.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Aza Compounds; Cefuroxime; Chromatography, High Pressure | 2010 |
Development of novel molecularly imprinted magnetic solid-phase extraction materials based on magnetic carbon nanotubes and their application for the determination of gatifloxacin in serum samples coupled with high performance liquid chromatography.
Topics: Adsorption; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Fluoroquinolones; Gatifloxa | 2013 |
Comparative killing rates of gatifloxacin and ciprofloxacin against 14 clinical isolates: impact of bacterial strain and antibiotic concentration.
Topics: Anti-Infective Agents; Blood Bactericidal Activity; Ciprofloxacin; Dose-Response Relationship, Drug; | 2002 |
Re-evaluation of quality control guidelines for gatifloxacin and garenoxacin (BMS284756) when susceptibility testing Haemophilus influenzae and Streptococcus pneumoniae.
Topics: Anti-Infective Agents; Drug Resistance, Bacterial; Fluoroquinolones; Gatifloxacin; Guidelines as Top | 2003 |
Determination of gatifloxacin in human serum and urine by high-performance liquid chromatography with ultraviolet detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Fluoroquinolones; Gatifloxacin; Humans; Reproduci | 2003 |
In vitro pharmacodynamic activity of gatifloxacin, gemifloxacin, moxifloxacin and levofloxacin against Streptococcus pneumoniae containing specific mutations in DNA gyrase and topoisomerase IV.
Topics: Analysis of Variance; Aza Compounds; Culture Media; DNA Gyrase; DNA Topoisomerase IV; Drug Resistanc | 2003 |
Susceptibility testing of Singapore strains of Mycoplasma hominis to tetracycline, gatifloxacin, moxifloxacin, ciprofloxacin, clindamycin, and azithromycin by the Etest method.
Topics: Anti-Bacterial Agents; Aza Compounds; Azithromycin; Ciprofloxacin; Clindamycin; Drug Resistance, Mul | 2004 |
Spectrofluorimetric and micelle-enhanced spectrofluorimetric determination of gatifloxacin in human urine and serum.
Topics: Fluoroquinolones; Gatifloxacin; Humans; Indicators and Reagents; Micelles; Sensitivity and Specifici | 2005 |
In vitro activity of fluoroquinolones against Mycobacterium tuberculosis.
Topics: Aza Compounds; Ciprofloxacin; Drug Resistance, Bacterial; Fluoroquinolones; Gatifloxacin; Humans; Mi | 2005 |
Quantitative determination of gatifloxacin, levofloxacin, lomefloxacin and pefloxacin fluoroquinolonic antibiotics in pharmaceutical preparations by high-performance liquid chromatography.
Topics: Anti-Bacterial Agents; Calibration; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chr | 2006 |
Determination of gatifloxacin and ornidazole in tablet dosage forms by high-performance thin-layer chromatography.
Topics: Anti-Infective Agents; Chromatography, High Pressure Liquid; Drug Combinations; Fluoroquinolones; Ga | 2006 |
Development and validation of an HPLC-UV method for the determination of gatifloxacin in bulk material, pharmaceutical formulations, human plasma and metal complexes.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Interactions; Fluoroquinolones | 2006 |
High performance liquid chromatography for quantification of gatifloxacin in rat plasma following automated on-line solid phase extraction.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Area Under Curve; Autoanalysis; Chromatography | 2007 |
Development and validation of an ion-pairing RP-HPLC method for the estimation of gatifloxacin in bulk and formulations.
Topics: Anti-Infective Agents; Calibration; Chromatography, High Pressure Liquid; Fluoroquinolones; Gatiflox | 2007 |
Determination of gatifloxacin in human plasma by liquid chromatography/electrospray tandem mass spectrometry.
Topics: Anti-Infective Agents; Chromatography, High Pressure Liquid; Ciprofloxacin; Fluoroquinolones; Gatifl | 2001 |
E test susceptibility testing of nosocomial Clostridium difficile isolates against metronidazole, vancomycin, fusidic acid and the novel agents moxifloxacin, gatifloxacin, and linezolid.
Topics: Acetamides; Anti-Infective Agents; Aza Compounds; Clostridioides difficile; Clostridium Infections; | 2002 |