gatifloxacin has been researched along with Otitis Media in 10 studies
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.
gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Otitis Media: Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gatifloxacin is a 4th-generation fluoroquinolone previously under investigation for the treatment of otitis media in infants and children." | 9.12 | Pharmacokinetics and pharmacodynamics of gatifloxacin in children with recurrent otitis media: application of sparse sampling in clinical development. ( Ambrose, P; Arguedas, A; Cirincione, B; Grasela, DM; Lopez, E; Rubino, CM; Sáez-Llorens, X; Sher, L, 2007) |
| "To compare gatifloxacin with amoxicillin/clavulanate in children with recurrent or nonresponsive acute otitis media (AOM)." | 9.11 | Randomized, investigator-blinded, multicenter study of gatifloxacin versus amoxicillin/clavulanate treatment of recurrent and nonresponsive otitis media in children. ( Arguedas, A; Echols, R; Hamed, KA; Pierce, P; Rodriguez, A; Sáez-Llorens, X; Yang, J, 2005) |
| "To compare the clinical efficacy of gatifloxacin with amoxicillin/clavulanate for the treatment of acute otitis media treatment failure and recurrent otitis media." | 9.11 | Randomized, investigator-blinded, multicenter, comparative study of gatifloxacin versus amoxicillin/clavulanate in recurrent otitis media and acute otitis media treatment failure in children. ( Arguedas, A; Biswas, D; Echols, R; Hamed, KA; Husseman, M; Pichichero, M; Pierce, P; Sher, L, 2005) |
| "To document the bacteriologic and clinical efficacy of gatifloxacin in recurrent/nonresponsive acute otitis media (AOM)." | 9.10 | Bacteriologic and clinical efficacy of oral gatifloxacin for the treatment of recurrent/nonresponsive acute otitis media: an open label, noncomparative, double tympanocentesis study. ( Dagan, R; Echols, RM; Greenberg, D; Hamed, KA; Jacobs, MR; Ledeine, JM; Leiberman, A; Leibovitz, E; Pierce, PF; Piglansky, L; Press, J; Raiz, S, 2003) |
| "This was an open label, multicenter trial in which patients with recurrent otitis media or acute otitis media (AOM) treatment failure were treated with 10 mg/kg gatifloxacin oral suspension once daily for 10 days." | 9.10 | Open label, multicenter study of gatifloxacin treatment of recurrent otitis media and acute otitis media treatment failure. ( Arguedas, A; Hamed, K; Lopez, E; Pierce, PF; Sáez-Llorens, X; Sher, L; Skuba, K, 2003) |
| " This study describes the safety and efficacy of gatifloxacin when used for treatment of children with recurrent acute otitis media (ROM) or acute otitis media (AOM) treatment failure (AOMTF)." | 8.82 | Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure. ( Arguedas, A; Dagan, R; Echols, R; Hamed, K; Pichichero, ME; Saez-Llorens, X; Sher, L, 2005) |
| "Gatifloxacin is a 4th-generation fluoroquinolone previously under investigation for the treatment of otitis media in infants and children." | 5.12 | Pharmacokinetics and pharmacodynamics of gatifloxacin in children with recurrent otitis media: application of sparse sampling in clinical development. ( Ambrose, P; Arguedas, A; Cirincione, B; Grasela, DM; Lopez, E; Rubino, CM; Sáez-Llorens, X; Sher, L, 2007) |
| "To compare gatifloxacin with amoxicillin/clavulanate in children with recurrent or nonresponsive acute otitis media (AOM)." | 5.11 | Randomized, investigator-blinded, multicenter study of gatifloxacin versus amoxicillin/clavulanate treatment of recurrent and nonresponsive otitis media in children. ( Arguedas, A; Echols, R; Hamed, KA; Pierce, P; Rodriguez, A; Sáez-Llorens, X; Yang, J, 2005) |
| "To compare the clinical efficacy of gatifloxacin with amoxicillin/clavulanate for the treatment of acute otitis media treatment failure and recurrent otitis media." | 5.11 | Randomized, investigator-blinded, multicenter, comparative study of gatifloxacin versus amoxicillin/clavulanate in recurrent otitis media and acute otitis media treatment failure in children. ( Arguedas, A; Biswas, D; Echols, R; Hamed, KA; Husseman, M; Pichichero, M; Pierce, P; Sher, L, 2005) |
| "To document the bacteriologic and clinical efficacy of gatifloxacin in recurrent/nonresponsive acute otitis media (AOM)." | 5.10 | Bacteriologic and clinical efficacy of oral gatifloxacin for the treatment of recurrent/nonresponsive acute otitis media: an open label, noncomparative, double tympanocentesis study. ( Dagan, R; Echols, RM; Greenberg, D; Hamed, KA; Jacobs, MR; Ledeine, JM; Leiberman, A; Leibovitz, E; Pierce, PF; Piglansky, L; Press, J; Raiz, S, 2003) |
| "This was an open label, multicenter trial in which patients with recurrent otitis media or acute otitis media (AOM) treatment failure were treated with 10 mg/kg gatifloxacin oral suspension once daily for 10 days." | 5.10 | Open label, multicenter study of gatifloxacin treatment of recurrent otitis media and acute otitis media treatment failure. ( Arguedas, A; Hamed, K; Lopez, E; Pierce, PF; Sáez-Llorens, X; Sher, L; Skuba, K, 2003) |
| " This study describes the safety and efficacy of gatifloxacin when used for treatment of children with recurrent acute otitis media (ROM) or acute otitis media (AOM) treatment failure (AOMTF)." | 4.82 | Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure. ( Arguedas, A; Dagan, R; Echols, R; Hamed, K; Pichichero, ME; Saez-Llorens, X; Sher, L, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leibovitz, E | 2 |
| Piglansky, L | 1 |
| Raiz, S | 1 |
| Greenberg, D | 1 |
| Hamed, KA | 3 |
| Ledeine, JM | 1 |
| Press, J | 1 |
| Leiberman, A | 1 |
| Echols, RM | 1 |
| Pierce, PF | 2 |
| Jacobs, MR | 1 |
| Dagan, R | 4 |
| Arguedas, A | 7 |
| Sher, L | 5 |
| Lopez, E | 2 |
| Sáez-Llorens, X | 5 |
| Hamed, K | 3 |
| Skuba, K | 1 |
| Schaad, UB | 1 |
| Rodriguez, A | 1 |
| Yang, J | 1 |
| Pierce, P | 2 |
| Echols, R | 4 |
| Husseman, M | 1 |
| Pichichero, M | 1 |
| Biswas, D | 1 |
| Pichichero, ME | 2 |
| Marchant, CD | 1 |
| Rubino, CM | 1 |
| Ambrose, P | 1 |
| Cirincione, B | 1 |
| Grasela, DM | 1 |
3 reviews available for gatifloxacin and Otitis Media
| Article | Year |
|---|---|
Potential role of fluoroquinolone therapy in childhood otitis media.
Topics: Anti-Infective Agents; Child; Child, Preschool; Drug Resistance, Microbial; Fluoroquinolones; Gatifl | 2004 |
Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure.
Topics: Anti-Infective Agents; Child; Clinical Trials as Topic; Fluoroquinolones; Gatifloxacin; Humans; Otit | 2005 |
The use of fluoroquinolones in children.
Topics: Anti-Infective Agents; Child; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Humans; Im | 2006 |
5 trials available for gatifloxacin and Otitis Media
| Article | Year |
|---|---|
Bacteriologic and clinical efficacy of oral gatifloxacin for the treatment of recurrent/nonresponsive acute otitis media: an open label, noncomparative, double tympanocentesis study.
Topics: Acute Disease; Administration, Oral; Child, Preschool; Drug Administration Schedule; Female; Fluoroq | 2003 |
Open label, multicenter study of gatifloxacin treatment of recurrent otitis media and acute otitis media treatment failure.
Topics: Acute Disease; Administration, Oral; Child; Child, Preschool; Female; Fluoroquinolones; Gatifloxacin | 2003 |
Randomized, investigator-blinded, multicenter study of gatifloxacin versus amoxicillin/clavulanate treatment of recurrent and nonresponsive otitis media in children.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Child; Child, Preschool; Femal | 2005 |
Randomized, investigator-blinded, multicenter, comparative study of gatifloxacin versus amoxicillin/clavulanate in recurrent otitis media and acute otitis media treatment failure in children.
Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Child; Child, P | 2005 |
Pharmacokinetics and pharmacodynamics of gatifloxacin in children with recurrent otitis media: application of sparse sampling in clinical development.
Topics: Anti-Infective Agents; Child, Preschool; Dose-Response Relationship, Drug; Female; Fluoroquinolones; | 2007 |
2 other studies available for gatifloxacin and Otitis Media
| Article | Year |
|---|---|
Gatifloxacin therapy for children: an antibiotic still in the "back room".
Topics: Anti-Infective Agents; Child; Drug Approval; Fluoroquinolones; Gatifloxacin; Humans; Otitis Media | 2005 |
Gatifloxacin therapy for children: turn on the light.
Topics: Child; Fluoroquinolones; Gatifloxacin; Humans; Otitis Media; Suspensions | 2005 |