gatifloxacin has been researched along with Neutropenia in 4 studies
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.
gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gatifloxacin (GA) is an alternative, though it has not been thoroughly studied in Pediatrics yet." | 6.73 | Oral gatifloxacin in the outpatient treatment of children with cancer fever and neutropenia. ( Alberto Pires Pereira, C; Altruda Carlesse, F; Petrilli, A, 2007) |
| "Patients with breast cancer or sarcoma who presented with fever and neutropenia and were identified as low risk received empiric, oral, quinolone monotherapy (gatifloxacin at a dose of 400 mg once daily)." | 3.73 | Once daily, oral, outpatient quinolone monotherapy for low-risk cancer patients with fever and neutropenia: a pilot study of 40 patients based on validated risk-prediction rules. ( Benjamin, RS; Elting, LS; Frisbee-Hume, SE; Manzullo, EF; McMahon, L; Patel, S; Rolston, KV; Theriault, RL, 2006) |
| "Gatifloxacin (GA) is an alternative, though it has not been thoroughly studied in Pediatrics yet." | 2.73 | Oral gatifloxacin in the outpatient treatment of children with cancer fever and neutropenia. ( Alberto Pires Pereira, C; Altruda Carlesse, F; Petrilli, A, 2007) |
| "Gatifloxacin was very active against Acinetobacter lwoffi (MIC100 0." | 1.32 | In vitro antimicrobial activity of gatifloxacin compared with other quinolones against clinical isolates from cancer patients. ( Frisbee-Hume, S; LeBlanc, B; Rolston, KV; Streeter, H; Vaziri, I, 2004) |
| "The pharmacodynamic parameters of peak serum drug concentration/MIC (peak/MIC) ratio and the area under the curve (AUC)/MIC ratio have been used to characterize in vivo drug exposure and its relationship to bacterial killing for the fluoroquinolones." | 1.31 | Pharmacodynamic assessment of gatifloxacin against Streptococcus pneumoniae. ( Banevicius, M; Li, D; Mattoes, HM; Nicolau, DP; Nightingale, CH; Turley, C; Xuan, D, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rolston, KV | 2 |
| Vaziri, I | 1 |
| Frisbee-Hume, S | 1 |
| Streeter, H | 1 |
| LeBlanc, B | 1 |
| Manzullo, EF | 1 |
| Elting, LS | 1 |
| Frisbee-Hume, SE | 1 |
| McMahon, L | 1 |
| Theriault, RL | 1 |
| Patel, S | 1 |
| Benjamin, RS | 1 |
| Petrilli, A | 1 |
| Altruda Carlesse, F | 1 |
| Alberto Pires Pereira, C | 1 |
| Mattoes, HM | 1 |
| Banevicius, M | 1 |
| Li, D | 1 |
| Turley, C | 1 |
| Xuan, D | 1 |
| Nightingale, CH | 1 |
| Nicolau, DP | 1 |
1 trial available for gatifloxacin and Neutropenia
| Article | Year |
|---|---|
Oral gatifloxacin in the outpatient treatment of children with cancer fever and neutropenia.
Topics: Administration, Oral; Adolescent; Adult; Ambulatory Care; Anti-Infective Agents; Antineoplastic Agen | 2007 |
3 other studies available for gatifloxacin and Neutropenia
| Article | Year |
|---|---|
In vitro antimicrobial activity of gatifloxacin compared with other quinolones against clinical isolates from cancer patients.
Topics: Anti-Bacterial Agents; Enterococcus; Fermentation; Fluoroquinolones; Follow-Up Studies; Gatifloxacin | 2004 |
Once daily, oral, outpatient quinolone monotherapy for low-risk cancer patients with fever and neutropenia: a pilot study of 40 patients based on validated risk-prediction rules.
Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Anti-Bacterial Agents; Breast Neoplasms; Feasibi | 2006 |
Pharmacodynamic assessment of gatifloxacin against Streptococcus pneumoniae.
Topics: Animals; Anti-Infective Agents; Area Under Curve; Colony Count, Microbial; Disease Models, Animal; F | 2001 |