gatifloxacin has been researched along with Long QT Syndrome in 7 studies
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.
gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a 54-year-old woman who, while being treated for acute sinusitis with gatifloxacin, presented with syncope and was found to have a markedly prolonged QT interval." | 3.72 | Gatifloxacin and prolonged QT interval. ( Ansari, SR; Chopra, N, 2004) |
| " In contrast, hyperglycemia without QT/QTc prolongations was noted 24 h after dosing in one animal." | 1.48 | Usefulness of simultaneous and sequential monitoring of glucose level and electrocardiogram in monkeys treated with gatifloxacin under conscious and nonrestricted conditions. ( Chiba, K; Ishizaka, T; Mori, K; Yoshimatsu, Y, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Yoshimatsu, Y | 1 |
| Ishizaka, T | 1 |
| Chiba, K | 2 |
| Mori, K | 1 |
| Ansari, SR | 1 |
| Chopra, N | 1 |
| Sugiyama, A | 1 |
| Hagiwara, T | 1 |
| Takahashi, S | 1 |
| Takasuna, K | 1 |
| Hashimoto, K | 1 |
| Anderson, ME | 1 |
| Mazur, A | 1 |
| Yang, T | 1 |
| Roden, DM | 1 |
| Lannini, PB | 1 |
| Circiumaru, I | 1 |
| Bertino, JS | 1 |
| Owens, RC | 1 |
| Carnes, TD | 1 |
| Iannini, PB | 1 |
7 other studies available for gatifloxacin and Long QT Syndrome
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
Usefulness of simultaneous and sequential monitoring of glucose level and electrocardiogram in monkeys treated with gatifloxacin under conscious and nonrestricted conditions.
Topics: Administration, Oral; Animals; Blood Glucose; Consciousness; Dose-Response Relationship, Drug; Elect | 2018 |
Gatifloxacin and prolonged QT interval.
Topics: Acute Disease; Electrocardiography; Female; Fluoroquinolones; Gatifloxacin; Humans; Long QT Syndrome | 2004 |
In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome.
Topics: Administration, Oral; Animals; Aza Compounds; Blood Pressure; Chloralose; Disease Models, Animal; Do | 2004 |
Potassium current antagonist properties and proarrhythmic consequences of quinolone antibiotics.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Cation Transport | 2001 |
Gatifloxacin-induced QTc prolongation and ventricular tachycardia.
Topics: Aged; Anti-Infective Agents; Female; Fluoroquinolones; Gatifloxacin; Humans; Long QT Syndrome; Synco | 2001 |
Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Female; Fluoroquinolones; Gatifloxacin; Heart; Human | 2002 |