Page last updated: 2024-11-04

gatifloxacin and Fasting Hypoglycemia

gatifloxacin has been researched along with Fasting Hypoglycemia in 33 studies

Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.
gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.

Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.

Research Excerpts

ExcerptRelevanceReference
"Gatifloxacin, a fluoroquinolone antimicrobial agent, has been reported to cause both hypoglycemia and hyperglycemia in diabetic and non-diabetic patients."7.76Gatifloxacin-induced histamine release and hyperglycemia in rats. ( Ishiwata, Y; Yasuhara, M, 2010)
"To compare rates of hypoglycemia and hyperglycemia among elderly hospitalized patients with normal blood glucose concentrations at baseline who were receiving either gatifloxacin or levofloxacin, and to determine if appropriateness of their doses, according to their package inserts, was associated with hypoglycemia or hyperglycemia."7.74Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients. ( Graves, J; Lodise, T; Lomaestro, B; Miller, C; Mohr, JF; Smith, RP, 2007)
"Gatifloxacin, until recently one of the most commonly prescribed antibiotics, has been shown to produce hypoglycemia."7.74Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study. ( Brown, R; Haerian, H; McHugh, P; Solomon, SS; Somes, G, 2008)
"We present the histories, clinical findings, and hospital course of three patients who developed hypoglycemia after receiving gatifloxacin."7.73Hypoglycemia associated with the use of gatifloxacin. ( Arce, FC; Bhasin, R; Pasmantier, R, 2005)
"A case of Gatifloxacin-induced severe and recurrent hypoglycemia in 62-year-old type 2 diabetic patient is presented."7.73Gatifloxacin-induced severe hypoglycemia in a patient with type 2 diabetes mellitus. ( Talwalkar, PG, 2006)
"Severe and resistant hypoglycemia occurred in two patients with diabetes mellitus who were receiving concomitant gatifloxacin and glyburide."7.72Severe and resistant hypoglycemia associated with concomitant gatifloxacin and glyburide therapy. ( Bélanger, C; Cossette, P; LeBlanc, M, 2004)
"To report a case of hypoglycemia in a patient receiving gatifloxacin for presumed exacerbation of chronic obstructive pulmonary disease (COPD)."7.71Possible gatifloxacin-induced hypoglycemia. ( Baker, SE; Hangii, MC, 2002)
"Gatifloxacin, a fluoroquinolone antimicrobial agent, has been reported to cause both hypoglycemia and hyperglycemia in diabetic and non-diabetic patients."3.76Gatifloxacin-induced histamine release and hyperglycemia in rats. ( Ishiwata, Y; Yasuhara, M, 2010)
"To compare rates of hypoglycemia and hyperglycemia among elderly hospitalized patients with normal blood glucose concentrations at baseline who were receiving either gatifloxacin or levofloxacin, and to determine if appropriateness of their doses, according to their package inserts, was associated with hypoglycemia or hyperglycemia."3.74Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients. ( Graves, J; Lodise, T; Lomaestro, B; Miller, C; Mohr, JF; Smith, RP, 2007)
"To assess the prevalence of dysglycemia (hypoglycemia or hyperglycemia) associated with oral levofloxacin and gatifloxacin therapy in an outpatient setting, and to determine the characteristics of patients who developed dysglycemia while receiving either fluoroquinolone."3.74Prevalence of and risk factors for dysglycemia in patients receiving gatifloxacin and levofloxacin in an outpatient setting. ( LaPlante, KL; Mersfelder, TL; Quilliam, BJ; Ward, KE, 2008)
"Gatifloxacin, until recently one of the most commonly prescribed antibiotics, has been shown to produce hypoglycemia."3.74Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study. ( Brown, R; Haerian, H; McHugh, P; Solomon, SS; Somes, G, 2008)
"A retrospective cohort study of hospitalized adult (> or =18 years) patients admitted with Community Acquired Pneumonia (CAP) or Acute Exacerbation of Chronic Bronchitis (AECB) in a US tertiary care hospital between 7/1/01 and 12/31/04 treated with gatifloxacin or ceftriaxone during hospital admission."3.74An evaluation of the effects of gatifloxacin on glucose homeostasis. ( Hatton, RC; Onyenwenyi, AJ; Winterstein, AG, 2008)
"We present the histories, clinical findings, and hospital course of three patients who developed hypoglycemia after receiving gatifloxacin."3.73Hypoglycemia associated with the use of gatifloxacin. ( Arce, FC; Bhasin, R; Pasmantier, R, 2005)
" In the first, case patients were persons treated in the hospital for hypoglycemia after outpatient treatment with a macrolide, a second-generation cephalosporin, or a respiratory fluoroquinolone (gatifloxacin, levofloxacin, moxifloxacin, or ciprofloxacin)."3.73Outpatient gatifloxacin therapy and dysglycemia in older adults. ( Dresser, L; Juurlink, DN; Kopp, A; Low, DE; Mamdani, MM; Park-Wyllie, LY; Shah, BR; Stukel, TA; Stumpo, C, 2006)
"Gatifloxacin, a commonly prescribed antimicrobial can produce profound hypoglycemia and disturbances in glucose homeostasis especially in diabetes patients on sulphonylureas."3.73Gatifloxacin induced abnormalities in glucose homeostasis in a patient on glimepiride. ( Kesavadev, J; Rasheed, SA, 2006)
"A case of Gatifloxacin-induced severe and recurrent hypoglycemia in 62-year-old type 2 diabetic patient is presented."3.73Gatifloxacin-induced severe hypoglycemia in a patient with type 2 diabetes mellitus. ( Talwalkar, PG, 2006)
"Severe and resistant hypoglycemia occurred in two patients with diabetes mellitus who were receiving concomitant gatifloxacin and glyburide."3.72Severe and resistant hypoglycemia associated with concomitant gatifloxacin and glyburide therapy. ( Bélanger, C; Cossette, P; LeBlanc, M, 2004)
"To report a case of hypoglycemia in a patient receiving gatifloxacin for presumed exacerbation of chronic obstructive pulmonary disease (COPD)."3.71Possible gatifloxacin-induced hypoglycemia. ( Baker, SE; Hangii, MC, 2002)
" In contrast, hyperglycemia without QT/QTc prolongations was noted 24 h after dosing in one animal."1.48Usefulness of simultaneous and sequential monitoring of glucose level and electrocardiogram in monkeys treated with gatifloxacin under conscious and nonrestricted conditions. ( Chiba, K; Ishizaka, T; Mori, K; Yoshimatsu, Y, 2018)
"Gatifloxacin was found to be the probable cause in the majority of cases."1.33Gatifloxacin-induced dysglycemia. ( Zvonar, R, 2006)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's29 (87.88)29.6817
2010's4 (12.12)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yoshimatsu, Y1
Ishizaka, T1
Chiba, K1
Mori, K1
Nagai, M1
Nagata, S1
Yamagishi, N1
Satoh, H1
Furuhama, K1
Ishiwata, Y1
Yasuhara, M1
Vinh, H1
Anh, VT1
Anh, ND1
Campbell, JI1
Hoang, NV1
Nga, TV1
Nhu, NT1
Minh, PV1
Thuy, CT1
Duy, PT1
Phuong, le T1
Loan, HT1
Chinh, MT1
Thao, NT1
Tham, NT1
Mong, BL1
Bay, PV1
Day, JN1
Dolecek, C1
Lan, NP1
Diep, TS1
Farrar, JJ1
Chau, NV1
Wolbers, M1
Baker, S1
Menzies, DJ1
Dorsainvil, PA1
Cunha, BA1
Johnson, DH1
Baker, SE1
Hangii, MC1
LeBlanc, M1
Bélanger, C1
Cossette, P1
Khovidhunkit, W1
Sunthornyothin, S1
Greenberg, AL1
Decerbo, M1
Fan, J1
Brogan, SE1
Cahalan, MK1
Graumlich, JF1
Habis, S1
Avelino, RR1
Salverson, SM1
Gaddamanugu, M1
Jamma, K1
Aldag, JC1
Mohr, JF2
McKinnon, PS1
Peymann, PJ1
Kenton, I1
Septimus, E1
Okhuysen, PC1
Bhasin, R1
Arce, FC1
Pasmantier, R1
Bushardt, RL1
Tailor, SA1
Simor, AE1
Cornish, W1
Phillips, EJ1
Knowles, S1
Rachlis, A1
Park-Wyllie, LY2
Juurlink, DN2
Kopp, A1
Shah, BR1
Stukel, TA1
Stumpo, C1
Dresser, L1
Low, DE1
Mamdani, MM1
Gurwitz, JH1
Kendall, C1
Wooltorton, E1
Hori, S1
Kizu, J1
Kawamura, M1
Ittner, KP1
Yadav, V1
Deopujari, K1
Smith, C1
Zvonar, R1
Catero, M1
Kesavadev, J1
Rasheed, SA1
Talwalkar, PG1
Lodise, T1
Graves, J1
Miller, C1
Lomaestro, B1
Smith, RP1
Kapral, MK1
LaPlante, KL1
Mersfelder, TL1
Ward, KE1
Quilliam, BJ1
Ali, T1
Greenfield, RA1
Scofield, H1
Bronze, MS1
Haerian, H1
McHugh, P1
Brown, R1
Somes, G1
Solomon, SS1
Onyenwenyi, AJ1
Winterstein, AG1
Hatton, RC1
Singh, N1
Jacob, JJ1

Reviews

1 review available for gatifloxacin and Fasting Hypoglycemia

ArticleYear
Dysglycemia and fluoroquinolones: are you putting patients at risk?
    The Journal of family practice, 2007, Volume: 56, Issue:2

    Topics: Adolescent; Adult; Aza Compounds; Bacterial Infections; Blood Glucose; Ciprofloxacin; Dose-Response

2007

Trials

1 trial available for gatifloxacin and Fasting Hypoglycemia

ArticleYear
A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children.
    PLoS neglected tropical diseases, 2011, Volume: 5, Issue:8

    Topics: Anti-Bacterial Agents; Child, Preschool; Ciprofloxacin; Dysentery, Bacillary; Feces; Female; Fluoroq

2011

Other Studies

31 other studies available for gatifloxacin and Fasting Hypoglycemia

ArticleYear
Usefulness of simultaneous and sequential monitoring of glucose level and electrocardiogram in monkeys treated with gatifloxacin under conscious and nonrestricted conditions.
    Experimental animals, 2018, May-10, Volume: 67, Issue:2

    Topics: Administration, Oral; Animals; Blood Glucose; Consciousness; Dose-Response Relationship, Drug; Elect

2018
Clinicopathological aspect of dysglycemia in naive and diabetic rats induced by the fluoroquinolone antibacterial gatifloxacin.
    The Journal of veterinary medical science, 2010, Volume: 72, Issue:5

    Topics: Administration, Oral; Animals; Anti-Infective Agents; Blood Glucose; Diabetes Mellitus, Experimental

2010
Gatifloxacin-induced histamine release and hyperglycemia in rats.
    European journal of pharmacology, 2010, Oct-25, Volume: 645, Issue:1-3

    Topics: Administration, Oral; Animals; Anti-Infective Agents; Blood Glucose; Diabetes Mellitus, Experimental

2010
Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents.
    The American journal of medicine, 2002, Aug-15, Volume: 113, Issue:3

    Topics: Administration, Oral; Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infections; Blood Gl

2002
Possible gatifloxacin-induced hypoglycemia.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:11

    Topics: Aged; Anti-Infective Agents; Fluoroquinolones; Gatifloxacin; Humans; Hypoglycemia; Male; Pulmonary D

2002
Severe and resistant hypoglycemia associated with concomitant gatifloxacin and glyburide therapy.
    Pharmacotherapy, 2004, Volume: 24, Issue:7

    Topics: Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Fluoroquinolones; Gatifloxacin; Glyburid

2004
Hypoglycemia, hyperglycemia, and gatifloxacin.
    Annals of internal medicine, 2004, Dec-21, Volume: 141, Issue:12

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Diabetes Mellitus, Type 2; Female; Fluoroquinolones;

2004
Gatifloxacin therapy associated with hypoglycemia.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Apr-15, Volume: 40, Issue:8

    Topics: Aged; Anti-Bacterial Agents; Cohort Studies; Fluoroquinolones; Gatifloxacin; Humans; Hypoglycemia; P

2005
Gatifloxacin as a possible cause of serious postoperative hypoglycemia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Anti-Infective Agents; Blood Glucose; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Coronary

2005
Hypoglycemia in inpatients after gatifloxacin or levofloxacin therapy: nested case-control study.
    Pharmacotherapy, 2005, Volume: 25, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Blood Glucose; Case-Control Studies; Female;

2005
A retrospective, comparative evaluation of dysglycemias in hospitalized patients receiving gatifloxacin, levofloxacin, ciprofloxacin, or ceftriaxone.
    Pharmacotherapy, 2005, Volume: 25, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Blood Glucose; Ceftriaxone; Ciprofloxacin; Fe

2005
Hypoglycemia associated with the use of gatifloxacin.
    The American journal of the medical sciences, 2005, Volume: 330, Issue:5

    Topics: Aged, 80 and over; Anti-Bacterial Agents; Blood Glucose; Female; Fluoroquinolones; Gatifloxacin; Hum

2005
Fluctuating blood glucose levels in an elderly diabetic patient.
    Southern medical journal, 2006, Volume: 99, Issue:1

    Topics: Aged; Blood Glucose; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Interactions; Fluoroq

2006
Glucose homeostasis abnormalities and gatifloxacin.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Mar-15, Volume: 42, Issue:6

    Topics: Aza Compounds; Fluoroquinolones; Gatifloxacin; Glucose; Homeostasis; Humans; Hyperglycemia; Hypoglyc

2006
Outpatient gatifloxacin therapy and dysglycemia in older adults.
    The New England journal of medicine, 2006, Mar-30, Volume: 354, Issue:13

    Topics: Aged; Aged, 80 and over; Ambulatory Care; Anti-Bacterial Agents; Case-Control Studies; Cephalosporin

2006
Serious adverse drug effects--seeing the trees through the forest.
    The New England journal of medicine, 2006, Mar-30, Volume: 354, Issue:13

    Topics: Anti-Bacterial Agents; Fluoroquinolones; Gatifloxacin; Humans; Hyperglycemia; Hypoglycemia

2006
People with diabetes should avoid antibiotic gatifloxacin.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006, Apr-11, Volume: 174, Issue:8

    Topics: Bacterial Infections; Case-Control Studies; Contraindications; Diabetes Mellitus; Fluoroquinolones;

2006
Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2006, Volume: 12, Issue:2

    Topics: Animals; Blood Glucose; Enoxacin; Fluoroquinolones; Gatifloxacin; Hypoglycemia; Male; Mice; Quinolon

2006
Gatifloxacin and dysglycemia in older adults.
    The New England journal of medicine, 2006, Jun-22, Volume: 354, Issue:25

    Topics: Anti-Bacterial Agents; Fluoroquinolones; Gatifloxacin; Humans; Hyperglycemia; Hypoglycemia

2006
Gatifloxacin and dysglycemia in older adults.
    The New England journal of medicine, 2006, Jun-22, Volume: 354, Issue:25

    Topics: Anti-Bacterial Agents; Fluoroquinolones; Gatifloxacin; Humans; Hyperglycemia; Hypoglycemia; Mortalit

2006
Timely Tequin warning.
    Nursing, 2006, Volume: 36, Issue:10

    Topics: Blood Glucose; Contraindications; Fluoroquinolones; Gatifloxacin; Glucose Tolerance Test; Humans; Hy

2006
Gatifloxacin-induced dysglycemia.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Nov-01, Volume: 63, Issue:21

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Female; Fluoroquinolones; Gatifloxacin; Humans; Hype

2006
Gatifloxacin induced abnormalities in glucose homeostasis in a patient on glimepiride.
    The Journal of the Association of Physicians of India, 2006, Volume: 54

    Topics: Anti-Infective Agents; Blood Glucose; Diabetes Mellitus; Female; Fluoroquinolones; Gatifloxacin; Hom

2006
Gatifloxacin-induced severe hypoglycemia in a patient with type 2 diabetes mellitus.
    The Journal of the Association of Physicians of India, 2006, Volume: 54

    Topics: Anti-Infective Agents; Blood Glucose; Diabetes Mellitus, Type 2; Fluoroquinolones; Gatifloxacin; Hum

2006
Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients.
    Pharmacotherapy, 2007, Volume: 27, Issue:11

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Cohort Studies; Dose-Response Relationship, Drug; Fe

2007
The effect of publication on Internet-based solicitation of personal-injury litigants.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007, Nov-20, Volume: 177, Issue:11

    Topics: Advertising; Aged; Anti-Infective Agents; Fluoroquinolones; Gatifloxacin; Humans; Hyperglycemia; Hyp

2007
Prevalence of and risk factors for dysglycemia in patients receiving gatifloxacin and levofloxacin in an outpatient setting.
    Pharmacotherapy, 2008, Volume: 28, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Azithromycin; Creatinin

2008
Gatifloxacin-associated hypoglycemia.
    The Journal of the Oklahoma State Medical Association, 2007, Volume: 100, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Diabetes Mellitus, Type

2007
Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study.
    The American journal of the medical sciences, 2008, Volume: 335, Issue:2

    Topics: Aged; Anti-Bacterial Agents; Female; Fluoroquinolones; Gatifloxacin; Humans; Hyperglycemia; Hypoglyc

2008
An evaluation of the effects of gatifloxacin on glucose homeostasis.
    Pharmacy world & science : PWS, 2008, Volume: 30, Issue:5

    Topics: Adult; Aged; Anti-Bacterial Agents; Blood Glucose; Bronchitis; Ceftriaxone; Cohort Studies; Communit

2008
Levofloxacin and hypoglycemia.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Apr-01, Volume: 46, Issue:7

    Topics: Clinical Competence; Fluoroquinolones; Gatifloxacin; Health Services Research; Hospitals, University

2008