gatifloxacin has been researched along with Experimental Pneumococcal Meningitis in 2 studies
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.
gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to evaluate the cerebrospinal fluid (CSF) pharmacodynamics of a new fluoroquinolone, gatifloxacin (AM-1155), in experimental pneumococcal meningitis." | 3.70 | Pharmacodynamics of gatifloxacin in cerebrospinal fluid in experimental cephalosporin-resistant pneumococcal meningitis. ( Friedland, IR; Ghaffar, F; Jafri, HS; Lutsar, I; McCoig, CC; McCracken, GH; Ng, W; Wubbel, L, 1998) |
| " Bactericidal activity of gatifloxacin was correlated with the area under the time-concentration curve-to-MBC ratio; maximal activity was achieved when gatifloxacin concentrations exceeded the MBC for the entire dosing interval." | 2.41 | Pharmacodynamics of gatifloxacin in experimental models of pneumococcal meningitis. ( McCracken, GH, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lutsar, I | 1 |
| Friedland, IR | 1 |
| Wubbel, L | 1 |
| McCoig, CC | 1 |
| Jafri, HS | 1 |
| Ng, W | 1 |
| Ghaffar, F | 1 |
| McCracken, GH | 2 |
1 review available for gatifloxacin and Experimental Pneumococcal Meningitis
| Article | Year |
|---|---|
Pharmacodynamics of gatifloxacin in experimental models of pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Child; Disease Models, Animal; Drug Administr | 2000 |
1 other study available for gatifloxacin and Experimental Pneumococcal Meningitis
| Article | Year |
|---|---|
Pharmacodynamics of gatifloxacin in cerebrospinal fluid in experimental cephalosporin-resistant pneumococcal meningitis.
Topics: Animals; Anti-Infective Agents; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Male; Me | 1998 |