gatifloxacin has been researched along with Critical Illness in 2 studies
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.
gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although concomitant tube feeding did not affect gatifloxacin bioavailability, critical illness resulted in significant variability that may complicate the role of gatifloxacin in sequential intravenous-to-oral therapy." | 5.10 | Bioavailability of gatifloxacin by gastric tube administration with and without concomitant enteral feeding in critically ill patients. ( Barletta, JF; Devlin, JW; Kanji, S; Kruse, JA; McKinnon, PS, 2003) |
| " Mean+/-standard deviation gatifloxacin elimination half-life (t(1/2)), systemic clearance and volume of distribution in patients with CrCL>or=40 mL/min were 10." | 2.73 | Evaluation of gatifloxacin pharmacokinetics and pharmacodynamics in severely ill adults in a medical Intensive Care Unit. ( Fish, DN, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanji, S | 1 |
| McKinnon, PS | 1 |
| Barletta, JF | 1 |
| Kruse, JA | 1 |
| Devlin, JW | 1 |
| Fish, DN | 1 |
2 trials available for gatifloxacin and Critical Illness
| Article | Year |
|---|---|
Bioavailability of gatifloxacin by gastric tube administration with and without concomitant enteral feeding in critically ill patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Infective Agents; APACHE; Biological Availabilit | 2003 |
Evaluation of gatifloxacin pharmacokinetics and pharmacodynamics in severely ill adults in a medical Intensive Care Unit.
Topics: Adult; Aged; Anti-Infective Agents; Area Under Curve; Case-Control Studies; Creatinine; Critical Ill | 2007 |