gastrins and Vitiligo

Gastric biopsies, and measurements of fasting serum gastrin levels and titers of antihuman parietal cell antibodies have been performed in 65 unselected patients with vitiligo. Histologic evidence of autoimmune atrophic gastritis has been obtained in 10 cases (15%), who were all positive for the antibodies and who had elevated gastrin levels. The study of gastric secretion after pentagastrin stimulation, performed in 7 of these patients, showed a markedly reduced acid output. The present study provides definite evidence of the association of autoimmune atrophic gastritis with a proportion of vitiligo cases and suggests the need for surveillance of these patients in terms of gastric neoplasia.

Topics: Adolescent; Adult; Autoantibodies; Autoimmune Diseases; Female; Gastric Acid; Gastrins; Gastritis; Gastritis, Atrophic; Humans; Male; Middle Aged; Vitiligo

Topics: Achlorhydria; Fasting; Gastrins; Humans; Vitiligo

Topics: Achlorhydria; Adolescent; Adult; Aged; Anemia, Pernicious; Autoantibodies; Female; Fluorescent Antibody Technique; Gastric Acidity Determination; Gastric Juice; Gastrins; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Radioimmunoassay; Skin Manifestations; Vitiligo

Topics: Adult; Age Factors; Aged; Gastrins; Gastritis; Humans; Middle Aged; Vitiligo

Topics: Achlorhydria; Adolescent; Adult; Age Factors; Aged; Anemia, Pernicious; Antibodies; Gastrins; Gastritis; Humans; Middle Aged; Vitiligo