gastrins and Vesico-Ureteral-Reflux

The use of segments of stomach for bladder augmentation is gaining popularity in pediatric urology due to favorable muscular and secretory properties. However, in a renal failure patient who underwent gastrocystoplasty a high level of acid production within the bladder associated with persistent hypergastrinemia was noted leading to severe systemic metabolic alkalosis. This condition was unresponsive to standard acid-inhibiting or neutralizing therapies but it was treated successfully with omeprazole, a proton-pump inhibitor recently introduced for treatment of peptic ulcer disease.

Topics: Alkalosis; Child, Preschool; Gastric Acid; Gastrins; Humans; Hydrogen-Ion Concentration; Male; Omeprazole; Postoperative Complications; Stomach; Urinary Bladder; Urine; Vesico-Ureteral Reflux