gastrins and Uterine-Cervical-Neoplasms

Examples of mucinous tumors from retroperitoneum (2) and pancreas (1) were studied. These tumors share many morphological similarities with ovarian mucinous tumour and adenoma malignum of uterine cervix. They have a similar spectrum of endocrine cells; serotonin, somatostatin, gastrin and pancreatic polypeptide cells were characterized. In nonproliferative areas was found a well-differentiated mucinous columnar epithelium with scarce endocrine cell. In more proliferative areas were found either a mucinous columnar lining with infolds and secondary glands or a less well-differentiated intestinal-type epithelium with papillary formations; both linings were well supplied in endocrine cells.

Topics: Adenocarcinoma; Adult; Endocrine Glands; Epithelium; Female; Fluorescent Antibody Technique; Gastrins; Histocytochemistry; Humans; Ovarian Neoplasms; Pancreatic Neoplasms; Pancreatic Polypeptide; Retroperitoneal Neoplasms; Serotonin; Somatostatin; Uterine Cervical Neoplasms

A radionuclide study of liver, small intestine function and a radioimmunoassay to determine the level of insulin, C-peptide and gastrin in the blood were performed in 177 patients with cervical cancer before and during radiation therapy and in 77 healthy women. Combined radiotherapy of cervical cancer was shown to result in disorder of absorptive-excretory function of the liver, disturbed fat assimilation in the small intestine and a decrease in gastrin production. Hyperfunction of the pancreas endocrine apparatus was noted in the cervical cancer patients, and radiation therapy caused the suppression of insulin production.

Topics: C-Peptide; Female; Gastrins; Humans; Insulin; Intestine, Small; Liver; Radionuclide Imaging; Radiotherapy; Uterine Cervical Neoplasms

Thirty patients with cervical adenocarcinoma were analyzed clinicopathologically with special reference to argyrophil cells. In contrast to argyrophil small cell carcinoma of the cervix, four adenocarcinomas with argyrophil cells were not more aggressive than the remaining 26 usual ones. One or two peptide hormones were demonstrated in three out of four tumors with argyrophil cells which were examined by immunohistochemistry. Somatostatin- and gastrin-containing cells were found in one tumor, but were located differently from each other. Either gastrin- or adrenocorticotropic hormone (ACTH)-containing cells were detected in two other tumors. They all corresponded to argyrophil cells, but were less numerous.

Topics: Adenocarcinoma; Adult; Enterochromaffin Cells; Female; Gastrins; Histocytochemistry; Humans; Immunoenzyme Techniques; Middle Aged; Peptides; Somatostatin; Uterine Cervical Neoplasms

Topics: C-Peptide; Female; Gastrins; Glucagon; Humans; Insulin; Radioimmunoassay; Trypsin; Uterine Cervical Neoplasms

Thirteen cases of argyrophil small cell carcinomas of the cervix were reviewed. Seven of nine patients, who have been followed up for more than 5 years, died. These tumors were found to be aggressive in their behavior. Immunohistochemical studies to localize several peptide hormones were positive for gastrin in two of five cases.

Topics: Adult; Carcinoma, Small Cell; Cervix Uteri; Cytoplasmic Granules; Female; Gastrins; Humans; Immunoenzyme Techniques; Middle Aged; Staining and Labeling; Uterine Cervical Neoplasms