gastrins and Liver-Diseases

Topics: Gastrins; Gonadal Steroid Hormones; Growth Hormone; Hormones; Humans; Liver Diseases; Thyroid Hormones

Topics: Animals; Duodenal Ulcer; Gastrins; Gastrointestinal Diseases; Humans; Intestine, Small; Liver Cirrhosis; Liver Diseases; Peptic Ulcer

Topics: Animals; Dogs; Gastric Juice; Gastric Mucosa; Gastrins; Humans; Intestine, Small; Liver; Liver Diseases; Pancreas; Pancreatic Diseases; Pentagastrin; Portal System; Rats; Secretory Rate

Topics: Air; Anemia, Pernicious; Angiography; Barium; Biopsy; Cholangiography; Colonic Diseases; Contrast Media; Cytodiagnosis; Duodenal Diseases; Endoscopy; Enema; Esophageal Diseases; Gastrins; Gastroenterology; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Gastroscopy; Glucose; Glucuronidase; Gold Isotopes; Insulin; Liver Diseases; Methionine; Pancreatic Diseases; Peptic Ulcer; Peptides; Rectal Neoplasms; Rose Bengal; Selenium; Silicones; Stomach Neoplasms; Vagotomy

Topics: Aldosterone; Angiotensin II; Animals; Aprotinin; Gastric Juice; Gastrins; Hepatitis; Histamine; Humans; Hydroxyindoleacetic Acid; Kinins; Liver Cirrhosis; Liver Diseases; Peptides; Renin; Serotonin

Topics: Animals; Chronic Disease; Dogs; Duodenal Ulcer; Gastric Acidity Determination; Gastric Juice; Gastrins; Histamine; Homocysteine; Humans; Liver Cirrhosis; Liver Diseases; Stomach

Dogs with liver disorders often display gastrointestinal signs that may be triggered by ulceration. The liver is important for inactivation of some forms of gastrin. Therefore, hypergastrinaemia has been implicated in the pathogenesis of gastrointestinal ulcerations related to liver dysfunction. The aim of this study was to determine serum gastrin concentrations in dogs with liver disease. Fasted blood samples were collected from 15 dogs with newly diagnosed liver disease and 18 healthy dogs. Gastrin concentrations were significantly lower in dogs with congenital portosystemic shunt compared with healthy dogs (P=0.003). No significant difference (P=0.6) in gastrin concentration was revealed between dogs with hepatocellular disease and healthy dogs. Serum gastrin concentrations were not significantly associated with the occurrence of vomiting, anorexia, diarrhoea, or melaena in dogs with liver disorders. These findings did not provide support for the role of hypergastrinaemia in the development of gastrointestinal signs associated with liver disease in dogs. Decreased serum concentrations of gastrin in a dog with liver disease may suggest the presence of portosystemic shunt. Further investigation is warranted to determine the importance of hyopogastrinaemia in congenital postosystemic shunts in dogs and to evaluate potential alterations in serum gastrin concentrations in specific hepatocellular diseases.

Topics: Animals; Biomarkers; Case-Control Studies; Dog Diseases; Dogs; Female; Gastrins; Gastrointestinal Diseases; Liver Diseases; Male; Ulcer

Malignant transformation in bile duct hamartomas has been previously reported in very rare instances. Here, we describe a unique case of a neuroendocrine tumor of the liver arising within an area of unusually large hamartoma with predominant bile duct component, hitherto unreported and distinct from the conventional von Meyenburg complex. The tumor was apparently secreting gastrin and chromogranin, with associated gastrinoma syndrome over several years. The histologic picture was reminiscent of a moderately differentiated adenocarcinoid, with positive mucin staining in a signet ring pattern. Tumor cells showed positive staining for neuron-specific enolase, chromogranin A, gastrin, and serotonin. Staining for pancreatic hormone peptides was negative. Resection of the tumor was apparently curative, with complete resolution of the patient's symptoms.

Topics: Bile Duct Diseases; Carcinoid Tumor; Chromogranin A; Chromogranins; Female; Gastrins; Hamartoma; Humans; Immunohistochemistry; Liver Diseases; Liver Neoplasms; Magnetic Resonance Imaging; Middle Aged; Radionuclide Imaging; Tomography, X-Ray Computed

Topics: Aged; Animals; Atrophy; Autoantibodies; Autoimmune Diseases; Case-Control Studies; Female; Gastric Mucosa; Gastrins; Humans; Immunity, Mucosal; Intestines; Liver Diseases; Male; Metaplasia; Middle Aged; Parietal Cells, Gastric; Rats

Topics: Calcitonin; Gastrins; Humans; Liver Diseases; Peptic Ulcer; Time Factors; Zollinger-Ellison Syndrome

Topics: Acute Disease; Animals; Gastrins; Gastrointestinal Hormones; Glucagon-Like Peptides; Liver Diseases; Pancreatic Polypeptide; Swine; Vasoactive Intestinal Peptide

Topics: Gastric Juice; Gastrins; Humans; Liver Diseases; Peptic Ulcer

Topics: Acute Disease; Animals; Dogs; Gastrins; Glucagon; Insulin; Kidney; Liver Diseases

Topics: Chronic Disease; Gastrins; Humans; Liver Diseases; Peptic Ulcer; Prednisone; Stimulation, Chemical

Topics: Animals; Biliary Tract Diseases; Dogs; Gastrins; Humans; Kidney Diseases; Liver Diseases

Topics: Animals; Gastrins; Hyperplasia; Intestinal Diseases; Intestine, Small; Liver; Liver Diseases; Male; Organ Size; Rats

The effects of somatostatin (growth hormone release inhibiting hormone) on basal gastrin were studied in patients suffering from pernicious anaemia and chronic renal and liver disease, and during sequential arginine/insulin-stimulated gastrin release in normal subjects. When basal gastrin concentrations were normal (10-50 pg/ml) in controls and in patients who were in renal and liver failure, somatostatin had no effect on gastrin levels. Raised basal gastrin levels in pernicious anaemia and in 2 cases of chronic renal disease, were significantly inhibited by somatostatin with a half-life (T 1/2) of 3-4 minutes. Arginine infusion caused an insignificant rise in serum gastrin which was unaffected by somatostatin, whereas insulin hypoglycaemia significantly stimulated gastrin release, which was inhibited by somatostatin.

Topics: Adult; Anemia, Pernicious; Arginine; Chronic Disease; Depression, Chemical; Gastrins; Humans; Insulin Antagonists; Kidney Failure, Chronic; Liver Diseases; Secretory Rate; Somatostatin; Stimulation, Chemical

Topics: Antibody Specificity; Gallbladder Diseases; Gastrins; Gastrointestinal Diseases; Humans; Liver Diseases; Radioimmunoassay

Topics: Adrenalectomy; Adult; Age Factors; Aged; Diabetes Mellitus; Female; Gastrectomy; Gastrins; Gastrointestinal Diseases; Humans; Hypophysectomy; Liver Diseases; Male; Middle Aged; Obesity; Pituitary Diseases; Radioimmunoassay; Sex Factors; Stomach Neoplasms; Thyroid Diseases

Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Female; Gastrins; Humans; Liver Diseases; Male; Middle Aged; Pancreatic Diseases; Radioimmunoassay; Sex Factors

Topics: Animals; Biliary Tract Diseases; Brain Diseases; Calcium; Cholecystectomy; Cholelithiasis; Cholesterol; Dihydroxyphenylalanine; Dogs; Duodenal Ulcer; Gastrectomy; Gastric Juice; Gastrins; Gastrointestinal Diseases; Humans; Hyperparathyroidism; Liver Diseases; Norepinephrine; Pancreas; Secretin; Serotonin; Stimulation, Chemical; Vagotomy

Topics: Gastrins; Gastrointestinal Diseases; Humans; Kidney Diseases; Liver Diseases; Pancreatic Diseases; Stomach Diseases

Topics: Animals; Dogs; Gastric Juice; Gastrins; Histamine; Liver Diseases; Peptic Ulcer

Topics: Anemia, Aplastic; Animals; Antibodies; Chronic Disease; Gastrins; Gastritis; Guinea Pigs; Humans; Liver Diseases; Peptic Ulcer; Rabbits; Radioimmunoassay

Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gastric Juice; Gastrins; Liver; Liver Diseases; Liver Function Tests; Male; Peptic Ulcer; Peptides; Rats

Topics: Cholelithiasis; Duodenal Ulcer; Fatty Liver; Gastric Acidity Determination; Gastrins; Gastrointestinal Diseases; Hepatitis; Humans; Lipid Metabolism; Liver Cirrhosis; Liver Diseases; Pancreas; Postgastrectomy Syndromes; Secretin; Sulfobromophthalein

Topics: Animals; Dogs; Gastric Juice; Gastrins; Histamine; Humans; Liver Diseases; Peptic Ulcer; Portacaval Shunt, Surgical

Topics: Biliary Tract Diseases; Biopsy; Diagnosis, Differential; Gastric Acidity Determination; Gastric Juice; Gastrins; Gastrointestinal Diseases; Gastroscopes; Humans; Liver Diseases; Male; Methods; Pancreatic Diseases; Pancreatic Juice

Topics: Animals; Dogs; Gastrins; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver Diseases; Peptic Ulcer; Physiology; Ulcer