gastrins and Hepatitis-B

The mild form of hepatitis A and B with children is attended by a functional activity of pancreatic gland (tripsin), mucous coats of stomach and duodenum (gastrin) which permits to consider them as a factor of the risk of digestive organs combined pathology starting with the disease acuity. Differences in gastrin levels with children depending on hepatitis etiology were specified. Highest levels of gastrin were observed with persons suffering from hepatitis B.

Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Digestive System; Female; Gastrins; Hepatitis A; Hepatitis B; Humans; Hydrocortisone; Immunoglobulin E; Male; Pepsinogen A; Serologic Tests; Trypsin

Topics: Adult; Biopsy, Needle; Calcinosis; Carrier State; Female; Gastrinoma; Gastrins; Hepatitis B; Humans; Immunohistochemistry; Liver Neoplasms; Tomography, X-Ray Computed

Histamine H2-receptor antagonists metiamide and cimetidine were used in the treatment of severe peptic ulceration in Zollinger-Ellison syndrome. The ulcerations were completely healed in all four patients after treatment lasting from six weeks to four-and-a-half-months. Two patients developed recurrent ulcer after the treatment had stopped, but responded to a second course. One patient developed hepatitis B during cimetidine treatment and it is possible that the course of the hepatitis was unfavourable affected by cimetidine. But no other side effects were noted nor was there a significant change in basal serum-gastrin concentration or an increase in H+ secretion. Total gastrectomy remains the treatment of choice in Zollinger-Ellison syndrome, but cimetidine should be considered if the patient refuses operation or operation is not feasible because of a poor general state.

Topics: Adult; Cimetidine; Female; Gastrins; Hepatitis B; Histamine H2 Antagonists; Humans; Male; Metiamide; Peptic Ulcer; Time Factors; Zollinger-Ellison Syndrome