gastrins and Enteritis

gastrins has been researched along with Enteritis* in 8 studies

Other Studies

8 other study(ies) available for gastrins and Enteritis

ArticleYear
Gastrin increases murine intestinal crypt regeneration following injury.
    Gastroenterology, 2006, Volume: 130, Issue:4

    A number of growth factors affect the regeneration of intestinal epithelia following injury, but the effects of amidated gastrin have not previously been assessed. We therefore investigated the effects of gastrin on intestinal regeneration following a range of stimuli.. Intestinal crypt regeneration was assessed in transgenic mice overexpressing amidated gastrin (INS-GAS) and mice in which hypergastrinemia was induced using omeprazole, following gamma-radiation, 5-fluorouracil, and dextran sulphate sodium (DSS). Abundance of the CCK-2 receptor was assessed in intestinal epithelia and IEC-6 intestinal epithelial cells following gamma-radiation.. Four days following 14 Gy gamma-radiation, or 2 injections of 400 mg/kg 5-fluorouracil, INS-GAS mice exhibited significantly increased small intestinal and colonic crypt survival compared with their wild-type counterparts (FVB/N). INS-GAS mice treated with 3% DSS for 5 days showed less weight loss and increased colonic crypt regeneration at 8 days compared with FVB/N. Increased small intestinal and colonic crypt survival was also demonstrated following gamma-radiation in FVB/N mice rendered hypergastrinemic using omeprazole. The increased crypt survival in INS-GAS mice following 14 Gy gamma-radiation was inhibited by administration of a CCK-2 receptor antagonist (YF476). Increased abundance of the CCK-2 receptor was demonstrated in intestinal epithelia following 14 Gy gamma-radiation by Western blotting and immunohistochemistry. Similarly, increased CCK-2 receptor mRNA abundance and increased 125I-gastrin binding was demonstrated in IEC-6 cells following 4 Gy gamma-radiation.. Hypergastrinemia increases regeneration of intestinal epithelia following diverse forms of injury. Induction of the CCK-2 receptor in damaged epithelium confers potential for protection against injury by administration of gastrin.

    Topics: Animals; Benzodiazepinones; Cell Line; Cell Proliferation; Colitis; Dextran Sulfate; Enteritis; Enzyme Inhibitors; Fluorouracil; Gamma Rays; Gastrins; Growth Substances; Intestinal Mucosa; Mice; Mice, Inbred Strains; Mice, Transgenic; Omeprazole; Phenylurea Compounds; Proton Pump Inhibitors; Receptor, Cholecystokinin B; Regeneration; Wounds and Injuries

2006
Serum gastrin in canine chronic lymphocytic-plasmacytic enteritis.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2005, Volume: 46, Issue:7

    This study evaluates serum gastrin concentrations in dogs with chronic lymphocytic-plasmacytic enteritis, as well as its possible relationship with the severity of lesions present in the stomach. To achieve this aim, 5 dogs without gastrointestinal disease and 15 dogs with chronic lymphocytic-plasmacytic enteritis were included. Serum gastrin concentrations were significantly increased in dogs with chronic lymphocytic-plasmacytic enteritis compared with those in dogs without gastrointestinal disease. Also, there was a positive correlation between the severity of the gastric lesion and the serum gastrin concentration. Our findings indicate the possibility that gastrin plays a role in the etiology of an accompanying chronic antral gastritis in canine chronic lymphocytic-plasmacytic enteritis.

    Topics: Analysis of Variance; Animals; Case-Control Studies; Chronic Disease; Dog Diseases; Dogs; Enteritis; Female; Gastrins; Male; Severity of Illness Index; Stomach

2005
[Alcohol and gastrointestinal diseases].
    Nederlands tijdschrift voor geneeskunde, 1979, Jul-21, Volume: 123, Issue:29

    Topics: Duodenal Diseases; Enteritis; Esophagus; Ethanol; Gastric Juice; Gastric Mucosa; Gastrins; Gastritis; Gastrointestinal Motility; Humans; Intestinal Absorption; Intestinal Mucosa; Lipoproteins

1979
[Serum concentration of gastrin in children with primary gastroduodenitis].
    Sovetskaia meditsina, 1977, Issue:2

    Topics: Child; Duodenal Diseases; Enteritis; Gastrins; Gastritis; Humans

1977
[Concentration of cortisol, gastrin, insulin and growth hormone in the blood serum of patients with chronic enterocolitis].
    Terapevticheskii arkhiv, 1977, Volume: 49, Issue:5

    Topics: Adult; Colitis; Enteritis; Female; Gastrins; Growth Hormone; Humans; Hydrocortisone; Insulin; Male

1977
Gastritis duodenitis, and circulating levels of gastrin in duodenal ulcer before and after vagotomy.
    Gut, 1976, Volume: 17, Issue:9

    Biopsy specimens have been taken from five standard sites in the stomach and from the duodenal bulb in order to investigate the association of gastritis and duodenitis with duodenal ulcer. Twenty patients with chronic duodenal ulcer were investigated in this manner and in addition had gastric secretion tests and a radio-immune assay of serum gastrin under differing conditions. The patients were then treated either by a truncal vagotomy and pyloroplasty (TVP) or by a highly selective vagotomy without a drainage procedure (HSV). All the investigations were repeated three months postoperatively. Duodenal ulcer was usually associated with gastriitis, although this varied in extent and severity from patient to patient. In nearly all the patients, gastritis was present at the pyloric end of the stomach and along the lesser curve. In more than half of the patients, gastritis was also present in the body of the stomach but the fundus was usually spared. Chronic duodenitis was found in the duodenal bulb in all these patients. After vagotomy there was a marked increase in both the extent and severity of the proximal gastritis in both treatment groups but the distal gastritis remain almost unchanged. There was little change in the incidence of duodenitis after vagotomy but its severity was lessened. No correlation was found between the peak acid output (PAO) in response to Histalog and the severity of the gastritis or the duodenitis either before or after operation, with one exception. The postoperative PAO was significantly less in those patients who developed a severe proximal gastritis after vagotomy. No relationship was found between the severity of the distal gastritis and the levels of serum gastrin. No correlation was found between either the basal or peak acid output and the corresponding serum gastrin levels before or after vagotomy.

    Topics: Biopsy; Duodenal Diseases; Duodenal Ulcer; Duodenum; Enteritis; Female; Gastric Juice; Gastrins; Gastritis; Humans; Male; Stomach; Vagotomy

1976
Proceedings: The pathophysiology of duodenitis.
    Gut, 1975, Volume: 16, Issue:5

    Topics: Duodenal Diseases; Duodenal Ulcer; Endoscopy; Enteritis; Gastric Juice; Gastrins; Humans

1975
[Significance of pancreatic function tests in the evaluation of digestive function. 3. Effect of histalog and gastrin in the pancreozymin secretin test].
    Iryo, 1970, Volume: 24, Issue:10

    Topics: Bicarbonates; Cholecystokinin; Enteritis; Gallbladder Diseases; Gastric Acidity Determination; Gastrins; Gastritis; Pancreas; Pancreatitis; Pyrazoles; Secretin; Stimulation, Chemical; Stomach Ulcer

1970