gastrins and Colonic-Diseases--Functional

Topics: Bradykinin; Cecum; Cholecystokinin; Colitis, Ulcerative; Colon; Colonic Diseases, Functional; Constipation; Diarrhea; Diverticulum, Colon; Gastrins; Gastrointestinal Motility; Humans; Muscle Contraction; Parasympathomimetics; Prostaglandins; Radiography; Rectum; Serotonin

Topics: Adolescent; Adult; Colitis, Ulcerative; Colonic Diseases, Functional; Crohn Disease; Gastrins; Humans; Middle Aged; Radioimmunoassay

Motilin, pancreatic polypeptide and gastrin blood concentrations in response to drinking water have been studied in 40 patients with functional bowel disease and compared with results in two groups of healthy control subjects. Patients with slow transit constipation and idiopathic megacolon showed impaired motilin release. Pancreatic polypeptide release was reduced in patients with slow transit constipation, but increased in those with functional diarrhoea. Gastrin release was impaired in all groups complaining of chronic constipation. Circulating motilin, pancreatic polypeptide and gastrin concentrations appear to bear some relationship to intestinal transit time in patients with functional bowel disorders.

Topics: Adult; Colonic Diseases, Functional; Constipation; Diarrhea; Drinking; Female; Gastrins; Humans; Intestinal Diseases; Male; Megacolon; Middle Aged; Motilin; Pancreatic Polypeptide; Water

In order to investigate the possible involvement of gastrointestinal hormones in functional disorders of the digestive tract, serum motilin, neurotensin and gastrin levels in their response to oral intake of fat and glucose were examined in patients with irritable colon syndrome and dumping syndrome. The following results were obtained. (1) Basal serum motilin levels were higher in patients with irritable colon syndrome than in normal subjects, and remained high after ingestion of either 50 g of butter or 50 g of glucose. (2) No consistent response in serum neurotensin levels was found in patients with irritable colon syndrome or in normal subjects. (3) An immediate increase in serum gastrin levels was found in response to fat ingestion both in patients with irritable colon syndrome and in normal subjects, but there was no difference between these two groups. (4) In a patient with typical dumping syndrome, a markedly high level of fasting serum motilin was found, and the level increased further after the oral intake of glucose. These findings suggest that motilin may be involved in the irritable colon syndrome and dumping syndrome.

Topics: Adult; Colonic Diseases; Colonic Diseases, Functional; Dietary Fats; Fasting; Gastrins; Gastrointestinal Hormones; Glucose; Humans; Motilin; Neurotensin

Topics: Adult; Colonic Diseases, Functional; Female; Gastrins; Humans; Male

Topics: Cholecystokinin; Colonic Diseases, Functional; Gastrins; Gastrointestinal Hormones; Gastrointestinal Motility; Humans

Topics: Bile Acids and Salts; Cholecystokinin; Colonic Diseases, Functional; Diarrhea; Gastrins; Gastrointestinal Motility; Humans; Lactose Intolerance; Stress, Psychological