gastrins and Cholecystitis

Different food tests were used to study endocrine function of the pancreas in 75 persons with a history of brucellosis and in 30 patients with chronic acalculous cholecystitis. In persons with a history of brucellosis, the endocrine part of the pancreas was involved, which manifested itself in a decrease in the secretory response of B cells to stimulation with glucose and mixed food enriched with proteins and fat. The alterations described are likely to be caused by the infection itself.

Topics: Adolescent; Adult; Blood Glucose; Brucellosis; Cholecystitis; Chronic Disease; Enterochromaffin Cells; Female; Gastrins; Glucose Tolerance Test; Humans; Insulin; Islets of Langerhans; Male; Middle Aged; Pancreatic Function Tests; Time Factors

A method for measurement of gastrin in human antral mucosa or in extragastric tissue has been developed and validated. Tissue gastrin was extracted by boiling followed by homogenization at neutral pH. Extractable gastrin immunoreactivity was measured by radioimmunoassay using an antiserum with equal affinity towards G-17 I, G-17 II, G-34 I and G-34 II molecular forms. Almost all extractable gastrin immunoreactivity was recovered after a single extraction and no significant interference by other peptides and/or substances present in tissue was found. The mean gastrin concentration in antral mucosa of healthy subjects was similar to that observed in duodenal ulcer patients, while patients with type A chronic atrophic gastritis or with antral gastrin cell hyperplasia had mean values significantly higher. Gastrin concentration in all specimens from gastrinoma or its metastases was above the upper limit of the range of control tissue. Measurement of tissue gastrin seems to be a valuable tool in the diagnosis of antral gastrin cell hyperplasia and Zollinger-Ellison syndrome.

Topics: Adolescent; Adult; Aged; Cholecystitis; Chronic Disease; Duodenal Ulcer; Female; Gastric Mucosa; Gastrins; Gastritis; Humans; Hyperplasia; Male; Middle Aged; Pancreatic Neoplasms; Pyloric Antrum; Zollinger-Ellison Syndrome

Topics: Adult; Cholecystitis; Chronic Disease; Duodenal Obstruction; Female; Gastrins; Humans; Male; Middle Aged; Pancreatitis; Peptic Ulcer

Topics: Adult; Aged; Amides; Cholecystitis; Dicarboxylic Acids; Female; Gastrins; Gastritis; Gastroenteritis; Humans; Male; Middle Aged; Peptic Ulcer

Topics: Biliary Dyskinesia; Cholecystitis; Cholecystokinin; Duodenum; Fats; Gastrins; Gastritis; Gastrointestinal Motility; Hepatitis A; Humans; Stomach

Topics: Amino Acids; Autonomic Nervous System Diseases; Cholecystitis; Duodenal Ulcer; Fatty Liver; Gastric Acidity Determination; Gastrins; Gastritis; Humans; Pancreatitis; Proctitis; Stomach Ulcer