gastrin-releasing-peptide has been researched along with Stomach-Ulcer* in 2 studies
2 other study(ies) available for gastrin-releasing-peptide and Stomach-Ulcer
| Article | Year |
|---|---|
GRP (gastrin-releasing peptide)-containing nerves in the rat stomach and stress-induced depletion of their synaptic vesicles. An electron microscope study.
Gastrin-releasing peptide (GRP)-containing nerves are extremely numerous in the mucosa of the gastric body. Our previous study demonstrated that depletion of GRP from the nerves occurred in close relation to ulceration in the stomach. The present study deals with the ultrastructure of the GRP-immunoreactive nerves under normal conditions and its changes induced by conditions of stress. The immunoreactivity for GRP was recognized selectively in large cored vesicles in the swollen axoplasm of the nerves. The same axoplasm further revealed immunonegative small clear vesicles which were believed to contain acetylcholine. In materials where the GRP-immunoreactive nerves markedly decreased in number, both large and small synaptic vesicles were depleted from the nerves. These findings suggest that GRP and acetylcholine coexist in single nerves in the oxyntic mucosa, and that by nerve stimulation, they are coreleased into the lamina propria. Topics: Acetylcholine; Animals; Capillaries; Gastric Mucosa; Gastrin-Releasing Peptide; Immobilization; Immunohistochemistry; Male; Nerve Fibers; Peptides; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological; Synaptic Vesicles | 1991 |
Depletion of gastrin-releasing peptide (GRP) from nerves in the gastric body of rats with experimental ulcers. An immunohistochemical study.
A predominant population of mucosal nerves in the mammalian gastric body has been known to contain large amounts of gastrin-releasing peptide (GRP). The present immunohistochemical study demonstrates the depletion of GRP immunoreactivity from nerves in the oxyntic mucosa of rats with ulcers induced by restraint plus water immersion. Depletion of GRP occurred in a major part of the nerves after 3 h exposure to the stress, and after 6 h exposure only a few nerve fibers could be recognized. In contrast, GRP fibers in the pyloric mucosa did not decrease significantly in number in any of the stressed rats. Since the depletion of GRP immunoreactivity preceded mucosal erosion in the gastric body, the possibility is proposed that GRP released from the nerves may be related to stress-related ulceration in the stomach. Topics: Animals; Gastric Mucosa; Gastrin-Releasing Peptide; Immunohistochemistry; Male; Peptides; Rats; Rats, Inbred Strains; Stomach; Stomach Ulcer; Stress, Physiological | 1988 |