gastrin-releasing-peptide and Periodontitis

Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have previously been suggested to play a role in the complex cascade of chemical activity associated with periodontal inflammation. In this study, GRP treatment enhanced the differentiation of bone marrow-derived macrophages (BMMs) into osteoclasts, and gastrin-releasing peptide receptor (GRPR) antagonists suppressed the pro-osteoclastogenic effect of GRP.

Topics: Alveolar Bone Loss; Animals; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Disease Models, Animal; Epithelial Cells; Female; Gastrin-Releasing Peptide; Gene Silencing; Humans; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred ICR; Osteogenesis; Periodontitis; Porphyromonas gingivalis; RANK Ligand; Real-Time Polymerase Chain Reaction; Receptors, Bombesin; RNA, Small Interfering; Signal Transduction