gastrin-releasing-peptide and Bone-Neoplasms

gastrin-releasing-peptide has been researched along with Bone-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for gastrin-releasing-peptide and Bone-Neoplasms

ArticleYear
Pro-gastrin-releasing peptide as a marker for the Ewing sarcoma family of tumors.
    International journal of clinical oncology, 2019, Volume: 24, Issue:11

    Pro-gastrin-releasing peptide (ProGRP) is an established tumor marker of small cell lung cancer. The purpose of this study was to determine if ProGRP could serve as a tumor marker for the Ewing sarcoma family of tumors (ESFTs).. Sixteen patients with ESFTs (mean age 32 years) were included in this study. As a control group, 42 patients with other tumor types that clinically or pathologically mimic ESFTs were also analyzed. Pre-treatment serum ProGRP and neuron-specific enolase (NSE) levels, the relationships between these levels, and tumor volume were investigated. In addition, serial changes in the serum or plasma ProGRP (6 patients) and NSE levels (5 patients) were measured over the course of treatment.. Pre-treatment serum ProGRP levels were higher than the normal range in 8 of 16 patients; for these eight patients, ProGRP levels positively correlated with tumor volume (R = 0.99). In the control group, ProGRP levels were within the normal range, except for the two patients. Changes in ProGRP levels during treatment were consistent with tumor volume. Serum NSE levels were elevated in 14 of 16 patients with ESFTs and 8 of 42 patients with other tumor types. The range of NSE elevation was much smaller compared to that of ProGRP. Our data indicate that ProGRP is superior to NSE in terms of specificity.. Serum ProGRP levels were elevated in half of the patients with ESFTs and reflected therapeutic response. ProGRP is a reliable tumor marker for the diagnosis of ESFTs and evaluation of treatment response.

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Bone Neoplasms; Case-Control Studies; Child; Female; Gastrin-Releasing Peptide; Humans; Male; Middle Aged; Phosphopyruvate Hydratase; Sarcoma, Ewing; Young Adult

2019
The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide.
    Cancer research, 1998, Jun-01, Volume: 58, Issue:11

    The Ewing tumor family of peripheral primitive neuroectodermal tumors (pPNETs) are characterized by chromosomal translocations leading to EWS-ETS gene fusions. These hybrid genes express chimeric proteins that are thought to act as aberrant transcription factors. We therefore used differential display-PCR to compare gene expression patterns in pPNET cell lines with those of other small round cell tumors (SRCTs) of childhood. This technique detected differential expression of sequences corresponding to human gastrin-releasing peptide (GRP) in pPNET cell lines but not in other SRCT cell lines. Subsequent Northern and reverse transcription-PCR analysis of SRCT cell lines confirmed GRP positivity in all pPNET lines tested. Of primary tumors tested by reverse transcription-PCR, GRP expression was found in 7 (44%) of 16 pPNETs but in no other primary SRCTs examined. Expression of the GRP receptor gene was demonstrable in 55% of pPNET cell lines and 25% of primary pPNET tumors but also in several other SRCTs. Radioimmunoassays and immunohistochemistry confirmed expression of bioactive GRP peptide in pPNET cell lines and primary tumors, respectively. Moreover, in vitro growth of a pPNET cell line was slowed by treatment with a GRP receptor antagonist and accelerated by a GRP receptor agonist. GRP is a known autocrine growth factor in small cell lung cancer and other neuroendocrine tumors. Its expression in pPNETs provides further evidence for a neuroectodermal histogenesis of these tumors and suggests that autocrine growth of this family of tumors may be at least partially regulated by GRP.

    Topics: Artificial Gene Fusion; Base Sequence; Bone Neoplasms; Carcinoma, Small Cell; Cloning, Molecular; Gastrin-Releasing Peptide; Humans; Molecular Sequence Data; Neuroectodermal Tumors, Primitive, Peripheral; Peptides; Polymerase Chain Reaction; Protein Precursors; Receptors, Bombesin; Sarcoma, Ewing; Sarcoma, Small Cell; Tumor Cells, Cultured

1998
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