gastrin-17 and Chest-Pain

The manifestations of gastroesophageal reflux disease (GERD) have been recently classified into either esophageal or extra-esophageal syndromes. Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD. Endoscopy had a low sensitivity. Recently, the availability of multichannel intraluminal impedance and pH-monitoring (MII-pH) has modified the diagnostic approach towards atypical manifestations of GERD. There is a rising consensus that this technique should be considered as the gold standard for GERD diagnosis. Gastrin 17 (G-17) has been proposed as a non-invasive marker of GERD, due to the negative feedback between acid and the hormone. G17 levels seem able to identify patients with acid and non-acid reflux.

Topics: Bilirubin; Body Fluids; Chest Pain; Diagnosis, Differential; Electric Impedance; Esophageal pH Monitoring; Gastrins; Gastroesophageal Reflux; Humans; Manometry; Monitoring, Ambulatory; Proton Pump Inhibitors; Symptom Assessment