garsubellin-a and Alzheimer-Disease

garsubellin-a has been researched along with Alzheimer-Disease* in 2 studies

Other Studies

2 other study(ies) available for garsubellin-a and Alzheimer-Disease

Article	Year
Evolution of a Synthetic Strategy for Garsubellin A. Chemistry (Weinheim an der Bergstrasse, Germany), 2022, Dec-20, Volume: 28, Issue:71 Garsubellin A is a thirty-carbon meroterpenoid capable of enhancing the enzyme choline acetyltransferase whose decreased level is associated with the symptoms of Alzheimer's disease. Due to the potentially useful biological activity along with the novel molecular architecture, this plant metabolite has remained a popular synthetic target. Herein we report a full account of our synthetic investigations that have led to the enantioselective total synthesis of garsubellin A, establishing its absolute stereostructure. The protecting group-free, twelve-step synthetic route has enabled the syntheses of the natural (-)-garsubellin A and its unnatural (+)-antipode. Topics: Alzheimer Disease; Biological Products; Choline O-Acetyltransferase; Humans; Stereoisomerism; Terpenes	2022
Progress toward the Synthesis of garsubellin A and related phloroglucins: the direct diastereoselective synthesis of the bicyclo[3.3.1]nonane core. Organic letters, 2002, May-30, Volume: 4, Issue:11 [reaction: see text] A highly diastereoselective single-step cyclization reaction provides access to the bicyclo[3.3.1]nonane core of the polyprenylated phloroglucin natural product garsubellin A. Further elaboration to a more functionalized analogue involves a sequential Claisen rearrangement/Grubbs olefin cross-metathesis strategy. Additionally, this strategy was extended to the preparation of the bis-quaternary carbon array found at the bridgehead positions of the phloroglucin natural products. Topics: Alzheimer Disease; Choline O-Acetyltransferase; Crystallography, X-Ray; Models, Molecular; Molecular Conformation; Neuroprotective Agents; Peptides, Cyclic; Plants, Medicinal; Stereoisomerism; Terpenes	2002

Article

Year

Evolution of a Synthetic Strategy for Garsubellin A.

Chemistry (Weinheim an der Bergstrasse, Germany), 2022, Dec-20, Volume: 28, Issue:71

Garsubellin A is a thirty-carbon meroterpenoid capable of enhancing the enzyme choline acetyltransferase whose decreased level is associated with the symptoms of Alzheimer's disease. Due to the potentially useful biological activity along with the novel molecular architecture, this plant metabolite has remained a popular synthetic target. Herein we report a full account of our synthetic investigations that have led to the enantioselective total synthesis of garsubellin A, establishing its absolute stereostructure. The protecting group-free, twelve-step synthetic route has enabled the syntheses of the natural (-)-garsubellin A and its unnatural (+)-antipode.

Topics: Alzheimer Disease; Biological Products; Choline O-Acetyltransferase; Humans; Stereoisomerism; Terpenes

2022

Progress toward the Synthesis of garsubellin A and related phloroglucins: the direct diastereoselective synthesis of the bicyclo[3.3.1]nonane core.

Organic letters, 2002, May-30, Volume: 4, Issue:11

[reaction: see text] A highly diastereoselective single-step cyclization reaction provides access to the bicyclo[3.3.1]nonane core of the polyprenylated phloroglucin natural product garsubellin A. Further elaboration to a more functionalized analogue involves a sequential Claisen rearrangement/Grubbs olefin cross-metathesis strategy. Additionally, this strategy was extended to the preparation of the bis-quaternary carbon array found at the bridgehead positions of the phloroglucin natural products.

Topics: Alzheimer Disease; Choline O-Acetyltransferase; Crystallography, X-Ray; Models, Molecular; Molecular Conformation; Neuroprotective Agents; Peptides, Cyclic; Plants, Medicinal; Stereoisomerism; Terpenes

2002