gant-61 and Primary-Myelofibrosis

Bone marrow fibrosis is a critical component of primary myelofibrosis in which normal bone marrow tissue and blood-forming cells are gradually replaced with scar tissue. The specific cellular and molecular mechanisms that cause bone marrow fibrosis are not understood. A recent study using state-of-the-art techniques, including in vivo lineage tracing, provides evidence that Gli1

Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Proliferation; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Transgenic; Molecular Targeted Therapy; Platelet Factor 4; Primary Myelofibrosis; Pyridines; Pyrimidines; Zinc Finger Protein GLI1

Bone marrow fibrosis (BMF) develops in various hematological and non-hematological conditions and is a central pathological feature of myelofibrosis. Effective cell-targeted therapeutics are needed, but the cellular origin of BMF remains elusive. Here, we show using genetic fate tracing in two murine models of BMF that Gli1

Topics: Animals; Cell Differentiation; Cell Proliferation; Humans; Mesenchymal Stem Cells; Mice; Mice, Transgenic; Myofibroblasts; Primary Myelofibrosis; Pyridines; Pyrimidines; Zinc Finger Protein GLI1