ganglioside--gd2 and Encephalitis

ganglioside--gd2 has been researched along with Encephalitis* in 1 studies

Other Studies

1 other study(ies) available for ganglioside--gd2 and Encephalitis

Article	Year
High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model. Cancer immunology research, 2018, Volume: 6, Issue:1 The GD2 ganglioside, which is abundant on the surface of neuroblastoma cells, is targeted by an FDA-approved therapeutic monoclonal antibody and is an attractive tumor-associated antigen for cellular immunotherapy. Chimeric antigen receptor (CAR)-modified T cells can have potent antitumor activity in B-cell malignancies, and trials to harness this cytolytic activity toward GD2 in neuroblastoma are under way. In an effort to enhance the antitumor activity of CAR T cells that target GD2, we generated variant CAR constructs predicted to improve the stability and the affinity of the GD2-binding, 14G2a-based, single-chain variable fragment (scFv) of the CAR and compared their properties Topics: Animals; CD3 Complex; Cell Line, Tumor; Cell Proliferation; Cytotoxicity, Immunologic; Disease Models, Animal; Encephalitis; Gangliosides; Gene Order; Genetic Vectors; Humans; Immunotherapy, Adoptive; Mice; Neuroblastoma; Receptors, Antigen, T-Cell; Receptors, Chimeric Antigen; Single-Chain Antibodies; T-Lymphocytes; Tumor Necrosis Factor Receptor Superfamily, Member 9; Xenograft Model Antitumor Assays	2018

Article

Year

High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model.

Cancer immunology research, 2018, Volume: 6, Issue:1

The GD2 ganglioside, which is abundant on the surface of neuroblastoma cells, is targeted by an FDA-approved therapeutic monoclonal antibody and is an attractive tumor-associated antigen for cellular immunotherapy. Chimeric antigen receptor (CAR)-modified T cells can have potent antitumor activity in B-cell malignancies, and trials to harness this cytolytic activity toward GD2 in neuroblastoma are under way. In an effort to enhance the antitumor activity of CAR T cells that target GD2, we generated variant CAR constructs predicted to improve the stability and the affinity of the GD2-binding, 14G2a-based, single-chain variable fragment (scFv) of the CAR and compared their properties

Topics: Animals; CD3 Complex; Cell Line, Tumor; Cell Proliferation; Cytotoxicity, Immunologic; Disease Models, Animal; Encephalitis; Gangliosides; Gene Order; Genetic Vectors; Humans; Immunotherapy, Adoptive; Mice; Neuroblastoma; Receptors, Antigen, T-Cell; Receptors, Chimeric Antigen; Single-Chain Antibodies; T-Lymphocytes; Tumor Necrosis Factor Receptor Superfamily, Member 9; Xenograft Model Antitumor Assays

2018