ganglioside--gd1a and Autoimmune-Diseases

ganglioside--gd1a has been researched along with Autoimmune-Diseases* in 3 studies

Reviews

2 review(s) available for ganglioside--gd1a and Autoimmune-Diseases

Article	Year
Human gangliosides and bacterial lipo-oligosaccharides in the development of autoimmune neuropathies. Methods in molecular biology (Clifton, N.J.), 2010, Volume: 600 Guillain-Barré syndrome (GBS), the most frequent cause of acute flaccid paralysis, can develop after infection by Campylobacter jejuni. The condition is often associated with serum anti-GM1 or anti-GD1a IgG antibodies. Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers. Autoantibodies to GM1 and GD1a disrupt lipid rafts, paranodal or nodal structures, and ion channel clusters in peripheral motor nerves. Molecular mimicry exists between GM1 and GD1a gangliosides and lipo-oligosaccharides of C. jejuni isolates from GBS patients. Sensitization of rabbits with GM1 or C. jejuni lipo-oligosaccharide produces replica of GBS. These findings provide strong evidence for carbohydrate mimicry being a cause of GBS and show the role of gangliosides in peripheral nerves. Topics: Animals; Autoimmune Diseases; Brain; Campylobacter jejuni; Cattle; Electrophysiology; G(M1) Ganglioside; Gangliosides; Humans; Immunoglobulin G; Lipopolysaccharides; Mice; Polyneuropathies; Rabbits; Sialyltransferases	2010
Specificity of antiglycolipid antibodies. Clinical reviews in allergy & immunology, 2000, Volume: 19, Issue:1 Topics: Antibody Specificity; Autoantibodies; Autoantigens; Autoimmune Diseases; Brain; Carbohydrate Sequence; CD57 Antigens; Chronic Disease; G(M1) Ganglioside; Gangliosides; Globosides; Glycolipids; Guillain-Barre Syndrome; Humans; Immunoglobulin M; Molecular Sequence Data; Motor Neuron Disease; Myelin Sheath; Paraproteinemias; Peripheral Nervous System; Polyradiculoneuropathy; Sulfoglycosphingolipids	2000

Article

Year

Human gangliosides and bacterial lipo-oligosaccharides in the development of autoimmune neuropathies.

Methods in molecular biology (Clifton, N.J.), 2010, Volume: 600

Guillain-Barré syndrome (GBS), the most frequent cause of acute flaccid paralysis, can develop after infection by Campylobacter jejuni. The condition is often associated with serum anti-GM1 or anti-GD1a IgG antibodies. Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers. Autoantibodies to GM1 and GD1a disrupt lipid rafts, paranodal or nodal structures, and ion channel clusters in peripheral motor nerves. Molecular mimicry exists between GM1 and GD1a gangliosides and lipo-oligosaccharides of C. jejuni isolates from GBS patients. Sensitization of rabbits with GM1 or C. jejuni lipo-oligosaccharide produces replica of GBS. These findings provide strong evidence for carbohydrate mimicry being a cause of GBS and show the role of gangliosides in peripheral nerves.

Topics: Animals; Autoimmune Diseases; Brain; Campylobacter jejuni; Cattle; Electrophysiology; G(M1) Ganglioside; Gangliosides; Humans; Immunoglobulin G; Lipopolysaccharides; Mice; Polyneuropathies; Rabbits; Sialyltransferases

2010

Specificity of antiglycolipid antibodies.

Clinical reviews in allergy & immunology, 2000, Volume: 19, Issue:1

Topics: Antibody Specificity; Autoantibodies; Autoantigens; Autoimmune Diseases; Brain; Carbohydrate Sequence; CD57 Antigens; Chronic Disease; G(M1) Ganglioside; Gangliosides; Globosides; Glycolipids; Guillain-Barre Syndrome; Humans; Immunoglobulin M; Molecular Sequence Data; Motor Neuron Disease; Myelin Sheath; Paraproteinemias; Peripheral Nervous System; Polyradiculoneuropathy; Sulfoglycosphingolipids

2000

Other Studies

1 other study(ies) available for ganglioside--gd1a and Autoimmune-Diseases

Article	Year
Factors defining target specificity in antibody-mediated neuropathy: density-dependent binding of anti-GD1a polyclonal IgG from a neurological patient. Journal of neuroscience research, 1997, Mar-15, Volume: 47, Issue:6 IgM and IgG antibodies reacting with components of human brain gangliosides were detected in a patient bearing severe sensory ataxy. Using different chemical and immunological methods, the antigen was identified as the GD1a ganglioside. The antibodies showed antigen "density-dependent" binding, a property only observed in tumor-specific monoclonal antibodies. The relevance of this result in regard with target specificity of neuropathy-associated antibodies directed to ubiquitous glycolipids is discussed. Topics: Antibody Specificity; Autoantibodies; Autoimmune Diseases; Gangliosides; Humans; Immunoglobulin A; Immunoglobulin G; Male; Middle Aged; Nervous System Diseases	1997

Article

Year

Factors defining target specificity in antibody-mediated neuropathy: density-dependent binding of anti-GD1a polyclonal IgG from a neurological patient.

Journal of neuroscience research, 1997, Mar-15, Volume: 47, Issue:6

IgM and IgG antibodies reacting with components of human brain gangliosides were detected in a patient bearing severe sensory ataxy. Using different chemical and immunological methods, the antigen was identified as the GD1a ganglioside. The antibodies showed antigen "density-dependent" binding, a property only observed in tumor-specific monoclonal antibodies. The relevance of this result in regard with target specificity of neuropathy-associated antibodies directed to ubiquitous glycolipids is discussed.

Topics: Antibody Specificity; Autoantibodies; Autoimmune Diseases; Gangliosides; Humans; Immunoglobulin A; Immunoglobulin G; Male; Middle Aged; Nervous System Diseases

1997