ganglioside--gd1a has been researched along with Ataxia* in 4 studies
4 other study(ies) available for ganglioside--gd1a and Ataxia
| Article | Year |
|---|---|
Bickerstaff's brainstem encephalitis associated with anti-GM1 and anti-GD1a antibodies.
Bickerstaff's brainstem encephalitis (BBE) is a Guillain-Barré syndrome (GBS) spectrum disorder associated with predominantly central nervous system predilection. Patients exhibit a variable constellation of depressed consciousness, bilateral external ophthalmoplegia, ataxia and long tract signs. Although the pathophysiology is not fully understood, it has been associated with anti-GQ1b antibodies in two-thirds of patients. We present a patient with clinical features consistent with BBE and positive anti-GM1 and anti-GD1a antibodies. A diagnostic approach to the acutely unwell patient with brainstem encephalitis is explored in this clinical context with a literature review of the aforementioned ganglioside antibody significance. Intravenous immunoglobulin therapy is highlighted in BBE using up-to-date evidence-based extrapolation from GBS. Topics: Adult; Ataxia; Autoantibodies; Brain Stem; Diagnosis, Differential; Electroencephalography; Encephalitis; G(M1) Ganglioside; Gangliosides; Glasgow Coma Scale; Humans; Male; Ophthalmoplegia | 2020 |
Ocular flutter, generalized myoclonus, and ataxia associated with anti-GM1, GD1a, and GD1b antibodies in a 6-year-old child.
Topics: Antibodies; Ataxia; Child; G(M1) Ganglioside; Gangliosides; Humans; Male; Myoclonus; Ocular Motility Disorders | 2018 |
Polycranial neuropathy and sensory ataxia with IgG anti-GD1a antibody as a variant of Guillain-Barré syndrome.
Immunoglobulin G (IgG) anti-GD1a ganglioside antibody is an important marker of Guillain-Barré syndrome (GBS). This antibody is highly associated with disease severity, the need for mechanical ventilation, and axonal degeneration of peripheral nerves. We report a 46-year-old female patient manifesting the IgG anti-GD1a antibody with polycranial neuropathy and sensory ataxia as a variant of GBS. She presented with slurred speech, swallowing difficulties, and gait disturbance following diarrhea. Decreased sensations of vibration and position were found in her distal limbs and she had an ataxic gait with a positive Romberg sign. Her serum was positive for IgG anti-GD1a ganglioside antibody (1:640). Her neurological examination at the third month after intravenous Ig treatment showed complete recovery. Topics: Ataxia; Autoantibodies; Autoantigens; Cranial Nerve Diseases; Enzyme-Linked Immunosorbent Assay; Female; Gangliosides; Guillain-Barre Syndrome; Humans; Immunoglobulin G; Middle Aged | 2013 |
Post-infectious acute ataxia and facial diplegia associated with anti-GD1a IgG antibody.
Topics: Adult; Ataxia; Facial Paralysis; Gangliosides; Guillain-Barre Syndrome; Humans; Immunoglobulin G; Immunotherapy; Infections; Male; Plasmapheresis | 2004 |