ganciclovir and Lymphoma--B-Cell

ganciclovir has been researched along with Lymphoma--B-Cell* in 1 studies

Other Studies

1 other study(ies) available for ganciclovir and Lymphoma--B-Cell

Article	Year
9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus. Journal of medicinal chemistry, 2007, May-03, Volume: 50, Issue:9 Several 9-(2-C-cyano-2-deoxy-l-beta-d-arabino-pentofuranosyl)purine derivatives were tested against Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma (PEL) cells. The guanine derivative (3, CNDAG), as well as the 2-amino-6-substituted-purine derivatives 4, 5, and 6, exhibited cell growth inhibitory activity against KSHV-infected cells, but showed no cytotoxicity against KSHV-negative cells at >15 microM concentrations. Therefore, it was found that compounds 3, 4, 5, and 6 showed selective cytotoxicity against PEL cells infected with KSHV. Topics: Antineoplastic Agents; Arabinonucleosides; Cell Line, Tumor; DNA; Epstein-Barr Virus Infections; Guanosine; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Lymphoma, B-Cell; RNA; Structure-Activity Relationship	2007

Article

Year

9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.

Journal of medicinal chemistry, 2007, May-03, Volume: 50, Issue:9

Several 9-(2-C-cyano-2-deoxy-l-beta-d-arabino-pentofuranosyl)purine derivatives were tested against Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma (PEL) cells. The guanine derivative (3, CNDAG), as well as the 2-amino-6-substituted-purine derivatives 4, 5, and 6, exhibited cell growth inhibitory activity against KSHV-infected cells, but showed no cytotoxicity against KSHV-negative cells at >15 microM concentrations. Therefore, it was found that compounds 3, 4, 5, and 6 showed selective cytotoxicity against PEL cells infected with KSHV.

Topics: Antineoplastic Agents; Arabinonucleosides; Cell Line, Tumor; DNA; Epstein-Barr Virus Infections; Guanosine; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Lymphoma, B-Cell; RNA; Structure-Activity Relationship

2007