gamma-sitosterol and Pseudomonas-Infections

gamma-sitosterol has been researched along with Pseudomonas-Infections* in 1 studies

Other Studies

1 other study(ies) available for gamma-sitosterol and Pseudomonas-Infections

ArticleYear
β-sitosterol ameliorates inflammation and Pseudomonas aeruginosa lung infection in a mouse model.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2023, Volume: 22, Issue:1

    We previously demonstrated that β-sitosterol (BSS) inhibits the expression of the chemokine IL-8 in CF bronchial epithelial cells exposed to P. aeruginosa. In the mouse model of lung chronic infection, herein shown, BSS significantly reduced leukocyte recruitment in the bronchoalveolar lavage fluid and decreased bacteria recovered in the airways. Treatment with BSS decreased the expression of key cytokines involved in immune response, mainly neutrophil chemotaxis, in the lung homogenate. This anti-inflammatory activity is accompanied by a beneficial protecting activity against infection and improvement of health status. Our data suggest that BSS has the potential to become a new drug to target the excessive neutrophil recruitment in lungs chronically infected by P. aeruginosa and encourage future investigations on mechanism of protection driven by BSS.

    Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Inflammation; Lung; Mice; Neutrophils; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections

2023