gamma-sitosterol has been researched along with Cystic-Fibrosis* in 2 studies
2 other study(ies) available for gamma-sitosterol and Cystic-Fibrosis
| Article | Year |
|---|---|
β-sitosterol ameliorates inflammation and Pseudomonas aeruginosa lung infection in a mouse model.
We previously demonstrated that β-sitosterol (BSS) inhibits the expression of the chemokine IL-8 in CF bronchial epithelial cells exposed to P. aeruginosa. In the mouse model of lung chronic infection, herein shown, BSS significantly reduced leukocyte recruitment in the bronchoalveolar lavage fluid and decreased bacteria recovered in the airways. Treatment with BSS decreased the expression of key cytokines involved in immune response, mainly neutrophil chemotaxis, in the lung homogenate. This anti-inflammatory activity is accompanied by a beneficial protecting activity against infection and improvement of health status. Our data suggest that BSS has the potential to become a new drug to target the excessive neutrophil recruitment in lungs chronically infected by P. aeruginosa and encourage future investigations on mechanism of protection driven by BSS. Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Inflammation; Lung; Mice; Neutrophils; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections | 2023 |
Severe Genotype, Pancreatic Insufficiency and Low Dose of Pancreatic Enzymes Associate with Abnormal Serum Sterol Profile in Cystic Fibrosis.
Several factors could lead to lipid disturbances observed in cystic fibrosis (CF). This study aimed to assess sterol homeostasis in CF and define potential exogenous and endogenous determinants of lipid dysregulation.. The study involved 55 CF patients and 45 healthy subjects (HS). Sterol concentrations (μg/dL) were measured by gas chromatography/mass spectrometry. CF was characterised by lung function, pancreatic status, liver disease and diabetes coexistence,. Independent determinants of lipid status suggest that malabsorption and pancreatic enzyme supplementation play a significant role in sterol abnormalities. The measurement of campesterol and β-sitosterol concentrations in CF patients may serve for the assessment of the effectiveness of pancreatic enzyme replacement therapy and/or compliance, but further research is required. Topics: Adolescent; Adult; Anthropometry; Cholesterol; Cystic Fibrosis; Enzyme Replacement Therapy; Exocrine Pancreatic Insufficiency; Female; Gas Chromatography-Mass Spectrometry; Genotype; Homeostasis; Humans; Lipids; Male; Middle Aged; Pancreas; Phytosterols; Sitosterols; Sterols; Young Adult | 2021 |