gamma-oryzanol and HIV-Infections

gamma-oryzanol has been researched along with HIV-Infections* in 1 studies

Other Studies

1 other study(ies) available for gamma-oryzanol and HIV-Infections

ArticleYear
Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.
    Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14

    Sixteen novel compounds; 3alpha-methoxyserrat-14-en-21beta-ol (1) and 3beta-methoxyserrat-14-en-21beta-ol (2) and their curcumin, kojic acid, quercetin, and baicalein conjugates (3)-(18) were designed, synthesized, and evaluated for in vitro anti-HIV-1 reverse transcriptase (RT) activity in infected C8166-CCR5 cells, a human CD4(+) T-lymphocyte cell line. Among them, kojic acid derivatives, 9-12 showed significant biological activity. In particular, the compound 13, the conjugate of two molecules of 3alpha-methoxyserrat-14-en-21beta-ol (1) and one molecule of kojic acid, exerted significant anti-HIV activity with an EC50 value of 0.12microg/mL.

    Topics: Antiviral Agents; Cell Line; Cell Survival; Curcumin; Flavanones; HIV Infections; HIV-1; Humans; Molecular Structure; Pyrones; Quercetin; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; T-Lymphocytes; Triterpenes; Viral Proteins

2009