gamma-linolenic-acid and Memory-Disorders

γ-Linolenic acid (GLA) is an important constituent of anti-ageing supplements.. The current study investigates the anti-ageing effect of GLA in Sprague-Dawley rats.. GLA (0.1, 0.2, 0.4, 2, 10, 20 and 24 μM) was initially evaluated for its effect on the formation of advanced glycation end products (AGEs) in vitro. For in vivo assessment (1, 5 or 15 mg/kg), the rat model of accelerated ageing was developed using d-fructose (1000 mg/kg (i.p.) plus 10% in drinking water for 40 days). Morris water maze was used to evaluate impairment in learning and memory. The blood of treated animals was used to measure glycosylated haemoglobin (HbA1c) levels. The interaction of GLA with active residues of receptor of AGE (RAGE) was analyzed using AutoDock Vina.. The GLA, at lower doses, possesses therapeutic potential against glycation-induced memory decline.

Topics: Animals; Behavior, Animal; Binding Sites; Cognitive Aging; Computational Biology; Dietary Supplements; Disease Models, Animal; Expert Systems; Fructose; gamma-Linolenic Acid; Glycated Hemoglobin; Glycation End Products, Advanced; Hydrophobic and Hydrophilic Interactions; Kinetics; Locomotion; Maze Learning; Memory Disorders; Molecular Conformation; Molecular Docking Simulation; Nootropic Agents; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products