gamma-linolenic-acid and Liver-Cirrhosis--Alcoholic

Evidence for the role of essential fatty acids in alcohol dependence is reviewed. If alcohol-induced tissue damage is associated with impaired fatty acid and phospholipid metabolism, supplements of essential fatty acids might be beneficial in the treatment of alcoholics. The evidence for this effect is examined.

Topics: Adult; Age Factors; Alcoholism; Brain; Clinical Trials as Topic; Cognition; Diazepam; Double-Blind Method; Erythrocyte Membrane; Ethanol; Fatty Acids, Essential; Fatty Acids, Unsaturated; gamma-Linolenic Acid; Humans; Linoleic Acids; Liver Cirrhosis, Alcoholic; Magnetic Resonance Spectroscopy; Middle Aged; Oenothera biennis; Phospholipids; Plant Oils; Substance Withdrawal Syndrome

Evidence for the role of essential fatty acids in alcohol dependence is reviewed. If alcohol-induced tissue damage is associated with impaired fatty acid and phospholipid metabolism, supplements of essential fatty acids might be beneficial in the treatment of alcoholics. The evidence for this effect is examined.

Topics: Adult; Age Factors; Alcoholism; Brain; Clinical Trials as Topic; Cognition; Diazepam; Double-Blind Method; Erythrocyte Membrane; Ethanol; Fatty Acids, Essential; Fatty Acids, Unsaturated; gamma-Linolenic Acid; Humans; Linoleic Acids; Liver Cirrhosis, Alcoholic; Magnetic Resonance Spectroscopy; Middle Aged; Oenothera biennis; Phospholipids; Plant Oils; Substance Withdrawal Syndrome

Topics: Adult; Fatty Acids, Essential; Female; gamma-Linolenic Acid; Humans; Linoleic Acids; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Function Tests; Male; Middle Aged; Oenothera biennis; Plant Oils

Alcohol has at least two actions on essential fatty acid (EFA) and Prostaglandin (PG) metabolism. It enhances the conversion of dihomogammalinolenic acid (DGLA) to PGE1 but it blocks the activity of the delta-6-desaturase, an enzyme necessary for replenishment of DGLA stores from dietary precursors. The acute effect of ethanol is therefore an increased production of PGE1 but chronic consumption will lead to depletion of DGLA and PGE1. Withdrawal from alcohol will lead to a precipitous fall in PGE1. PGE1 is known to have profound effects on the nervous system and behaviour. Patients with mania produce more PGE1 than normal while those with depression make less. Alcoholics may drink to maintain a normal PGE1 level, something which will require more and more ethanol as DGLA is depleted. In both animals and humans PGE1 or its precursor, gamma-linolenic acid (GLA) have been shown to attenuate the acute withdrawal syndrome. PGE1 injections prevent the development of fatty liver in alcohol-treated animals. Defective EFA and PGE1 metabolism are known to lead to increased fibrosis, reproductive failure, cardiomyopathy, cardiovascular disorders, gastritis and pancreatitis and could therefore be the basis for these disorders in alcoholics. A PGE1 deficiency could also be responsible for the fetal alcohol syndrome. Three other agents are known to produce constellations of fetal defects very similar to those found in the alcohol syndrome. These other factors are dihphenylhydantoin, lithium, and a deficiency of zinc. These three factors and excessive alcohol consumption all lead to PGE1 deficiency by different routes. If this concept is correct, the key to the management of alcoholism and its medical complications lies in the provision of GLA or DGLA, fatty acids which by-pass the alcohol blocked step and which are unfortunately unlikely to be present in any normal diet. Unlike many concepts of alcoholism and alcohol damage, the EFA/PGE1 idea is very readily testable and already has considerable experimental support.

Topics: 8,11,14-Eicosatrienoic Acid; Alcoholism; Fatty Acids, Essential; Female; Fetal Alcohol Spectrum Disorders; gamma-Linolenic Acid; Humans; Linolenic Acids; Lithium; Liver Cirrhosis, Alcoholic; Pregnancy; Prostaglandins; Prostaglandins E; Substance Withdrawal Syndrome