gamma-linolenic-acid and Erythema

The purpose of the study was to analyze the potential capacity of a dietary supplement, based on gamma linolenic acid, vitamin E, vitamin C, beta-carotene, coenzyme Q10 and Vitis Vitifera, to reduce side effects, in particular the dry skin, erythema and desquamation, due to treatment with oral isotretinoin, and evaluate the ability of the product to increase adherence to therapy in patients with acne.. Forty-eight patients with nodular acne (32 females and 16 males) were randomly divided into 2 groups: 24 received isotretinoin therapy (20-30 mg/day) for 6 months associated to dietary supplement (twice a day), while the other 24 patients received only isotretinoin (20-30 mg/day) for 6 months. For all patients the degree of acne severity, through GAGS (Global Acne Grading System), the sebum production by Sebutape, the hydration by Corneometer and the erythema by Mexameter, were measured. We have also evaluated the adherence to treatment, asking to patients how many days a week they follow the therapy.. Patients treated with dietary supplement had lower side effects, with a less degree of erythema and dryness, and greater degree of hydration; a greater adherence to therapy was also reported.. Thanks to antioxidant and moisturizing properties, the dietary supplement containing gamma linolenic acid, vitamin E, vitamin C, betacarotene, coenzyme Q10 and Vitis Vitifera, can be considered a useful supplement in the treatment and prevention of dry skin associated with the use of oral isotretinoin.

Topics: Acne Vulgaris; Administration, Oral; Adolescent; Adult; Ascorbic Acid; beta Carotene; Dermatologic Agents; Dietary Supplements; Dose-Response Relationship, Drug; Erythema; Female; gamma-Linolenic Acid; Humans; Isotretinoin; Italy; Male; Severity of Illness Index; Skin; Treatment Outcome; Ubiquinone; Vitamin E; Vitamins; Vitis

A randomised double-blind parallel study lasting eight weeks was used to assess the effects of olive oil in a group of atopic dogs whose clinical signs were well controlled by dietary supplementation with a combination of evening primrose oil and fish oil. Nine of the 11 dogs which continued to receive this combination were considered unchanged at the conclusion of the study, whereas eight of the 10 dogs switched to olive oil had deteriorated. The mean plasma concentration of dihomogammalinolenic acid, a precursor of potentially antiinflammatory mediators, was significantly reduced (P < 0.05) in the olive oil-treated group at the end of the study. There were no significant differences between the mean plasma linoleic, eicosapentaenoic and arachidonic acid concentrations in the two groups. These findings suggest that olive oil is not an effective therapeutic agent in the control of canine atopy.

Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fats, Unsaturated; Dog Diseases; Dogs; Double-Blind Method; Drug Combinations; Erythema; Fatty Acids, Essential; Female; Fish Oils; gamma-Linolenic Acid; Hypersensitivity, Immediate; Linoleic Acids; Male; Oenothera biennis; Olive Oil; Plant Oils; Pruritus; Treatment Outcome

The ability of essential fatty acids (EFAs) to modulate radiation-induced normal tissue injury was assessed in pig skin. Female Large White pigs (approximately 25 Kg) received 3 ml/day orally of either an 'active' oil [So-1100, containing 9% gamma-linolenic acid (GLA)] or a 'placebo' oil (So-1129) for just 4 weeks before or for 4 weeks before and for 16 weeks after irradiation; localised irradiation of skin was with single doses of beta-rays from 22.5 mm diameter 90Sr/90Y plaques. The severity of the acute reaction, assessed in terms of erythema or moist desquamation, was significantly less in those pigs that received So-1100 both before and after irradiation, as compared with those receiving that oil only prior to irradiation and the 'placebo' groups. Dose modification factors (DMFs) of between 1.13-1.24 were obtained. A similar reduction in the severity of acute skin injury was seen in pigs receiving So-1100 for only 10 weeks after irradiation. Late skin damage, assessed in terms of late erythema or dermal necrosis, was also reduced with So-1100, with DMFs of 1.14-1.51. No such modification was observed if So-1100 was only administered for 4 weeks prior to irradiation. No adverse side-effects were apparent as a result of EFA administration. So-1100 may represent a safe and valuable method of increasing the therapeutic gain in radiotherapy.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Beta Particles; Dose-Response Relationship, Radiation; Erythema; Fatty Acids, Essential; Female; gamma-Linolenic Acid; Linolenic Acids; Radiation Injuries, Experimental; Radiation-Protective Agents; Skin; Strontium; Swine; Yttrium Radioisotopes