gamma-linolenic-acid and Dermatitis

Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.

Topics: Acne Vulgaris; Dermatitis; Fatty Acids, Omega-3; Fatty Acids, Omega-6; gamma-Linolenic Acid; Gene Expression Regulation; Humans; Psoriasis; Toll-Like Receptors

Topics: alpha-Linolenic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Arthritis; Blood Pressure; Coronary Artery Disease; Dermatitis; Dermatologic Agents; Fatty Acids, Essential; gamma-Linolenic Acid; Humans; Hypertension; Hypolipidemic Agents; Linoleic Acids; Lipids; Oenothera biennis; Plant Oils; Platelet Aggregation; Treatment Outcome

Topics: Azacitidine; Dermatitis; gamma-Linolenic Acid; Humans; Linoleic Acids; Myelodysplastic Syndromes; Oenothera biennis; Plant Oils

Topics: Dermatitis; gamma-Linolenic Acid; Humans; Linoleic Acids; Oenothera biennis; Plant Oils

Fourteen cats with crusting dermatoses ('miliary dermatitis') were supplemented with various combinations of evening primrose oil and fish oil. The cutaneous signs improved when the cats were supplemented with either evening primrose oil alone or with a combination of evening primrose oil and fish oil. Fish oil alone was unable to maintain the remission and the cutaneous signs deteriorated. The subsequent administration of a combination of the two oils resulted in a resolution of the dermatosis.

Topics: Animals; Bites and Stings; Cat Diseases; Cats; Dermatitis; Dermatologic Agents; Fatty Acids; Fatty Acids, Essential; Female; Fish Oils; gamma-Linolenic Acid; Hypersensitivity; Linoleic Acids; Male; Oenothera biennis; Plant Oils; Siphonaptera

Eleven cats with papulocrustous dermatitis were randomly assigned to one of two groups and supplemented with either evening primrose oil or sunflower oil for 12 weeks. Clinical scores were assessed at intervals of three weeks and blood samples were taken for the analysis of plasma and erythrocyte fatty acid concentrations. The cats in both groups improved during the period of treatment and the concentration of linoleic acid in erythrocyte phospholipid increased in the cats fed evening primrose oil. Six weeks after the supplement was withdrawn the cats fed evening primrose oil had deteriorated less than those fed sunflower oil.

Topics: Animals; Cat Diseases; Cats; Dermatitis; Dermatologic Agents; Fatty Acids, Essential; Female; gamma-Linolenic Acid; Linoleic Acids; Male; Oenothera biennis; Plant Oils; Random Allocation; Sunflower Oil; Time Factors