gamma-endorphin and Stomach-Ulcer

Grimelius reaction and immunohistochemical PAP method were used to study endocrine cells producing gastrin (G-cells), somatostatin (D-cells) and gamma-endorphin (GER-cells) in gastric and duodenal mucosa of 95 males with atrophic gastritis with intestinal and pyloric metaplasia. The number of cells was counted per 1 mm2 of the mucosa. In the cases of marked intestinal metaplasia the number of G-, GER- and especially D-cells in the pyloric region non-metaplastic epithelium decreases and is approaching to its number in the duodenum of the control group. In the foci of marked pyloric metaplasia of gastric corpus the number of G- and GER-cells is almost the same as in the zones of gastric metaplasia of duodenum, and is approximating their number in the pyloric region of controls, thus allowing the designation of pyloric metaplasia as a complete one.

Topics: Adolescent; Adult; Aged; APUD Cells; Biopsy; Duodenal Ulcer; Duodenum; Endorphins; gamma-Endorphin; Gastric Mucosa; Gastrins; Gastritis, Atrophic; Histocytochemistry; Humans; Immunoenzyme Techniques; Metaplasia; Middle Aged; Pylorus; Somatostatin; Stomach Ulcer