gamma-endorphin and Psychotic-Disorders

gamma-endorphin has been researched along with Psychotic-Disorders* in 3 studies

Trials

2 trial(s) available for gamma-endorphin and Psychotic-Disorders

ArticleYear
The treatment of schizophrenic psychoses with gamma-type endorphins.
    Biological psychiatry, 1982, Volume: 17, Issue:1

    The pharmacological actions of gamma-type endorphins show similarities to those of the neuroleptics. Two fragments of gamma-endorphin (beta-LPH 61-77) were therefore tested in patients with schizophrenic and schizo-affective psychoses who had shown an insufficient response to neuroleptics. The fragments were DT gamma E (beta-LPH 62-77) and DE gamma E (beta-LPH 66-77). Some of the patients studied responded favorably to this treatment. A number of criteria of differentiation between responders and nonresponders are discussed. The influence of DT gamma E on the central DA metabolism differs from that of the neuroleptics. It is therefore conceivable that gamma-type endorphins represent a different principle of action. The therapeutic efficacy of these compounds lends support to the hypothesis that disorders of central endorphin metabolism may play a role in the pathogenesis of psychoses of the schizophrenic type.

    Topics: beta-Endorphin; Brain; Clinical Trials as Topic; Dopamine; Double-Blind Method; Endorphins; gamma-Endorphin; Humans; Peptide Fragments; Psychotic Disorders; Receptors, Dopamine; Schizophrenia; Schizophrenic Psychology

1982
[Treatment of schizophrenic psychoses with gamma-type endorphins].
    Nederlands tijdschrift voor geneeskunde, 1981, Nov-28, Volume: 125, Issue:48

    Topics: Brief Psychiatric Rating Scale; Double-Blind Method; Drug Evaluation; Endorphins; gamma-Endorphin; Humans; Peptide Fragments; Psychotic Disorders; Schizophrenia

1981

Other Studies

1 other study(ies) available for gamma-endorphin and Psychotic-Disorders

ArticleYear
Neuroleptic-like and antipsychotic effects of gamma-type endorphins.
    Modern problems of pharmacopsychiatry, 1981, Volume: 17

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; beta-Endorphin; Dopamine; Double-Blind Method; Endorphins; gamma-Endorphin; Humans; Peptide Fragments; Psychiatric Status Rating Scales; Psychotic Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Schizophrenia; Schizophrenic Psychology

1981