gamma-endorphin has been researched along with Psychotic-Disorders* in 3 studies
2 trial(s) available for gamma-endorphin and Psychotic-Disorders
Article | Year |
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The treatment of schizophrenic psychoses with gamma-type endorphins.
The pharmacological actions of gamma-type endorphins show similarities to those of the neuroleptics. Two fragments of gamma-endorphin (beta-LPH 61-77) were therefore tested in patients with schizophrenic and schizo-affective psychoses who had shown an insufficient response to neuroleptics. The fragments were DT gamma E (beta-LPH 62-77) and DE gamma E (beta-LPH 66-77). Some of the patients studied responded favorably to this treatment. A number of criteria of differentiation between responders and nonresponders are discussed. The influence of DT gamma E on the central DA metabolism differs from that of the neuroleptics. It is therefore conceivable that gamma-type endorphins represent a different principle of action. The therapeutic efficacy of these compounds lends support to the hypothesis that disorders of central endorphin metabolism may play a role in the pathogenesis of psychoses of the schizophrenic type. Topics: beta-Endorphin; Brain; Clinical Trials as Topic; Dopamine; Double-Blind Method; Endorphins; gamma-Endorphin; Humans; Peptide Fragments; Psychotic Disorders; Receptors, Dopamine; Schizophrenia; Schizophrenic Psychology | 1982 |
[Treatment of schizophrenic psychoses with gamma-type endorphins].
Topics: Brief Psychiatric Rating Scale; Double-Blind Method; Drug Evaluation; Endorphins; gamma-Endorphin; Humans; Peptide Fragments; Psychotic Disorders; Schizophrenia | 1981 |
1 other study(ies) available for gamma-endorphin and Psychotic-Disorders
Article | Year |
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Neuroleptic-like and antipsychotic effects of gamma-type endorphins.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; beta-Endorphin; Dopamine; Double-Blind Method; Endorphins; gamma-Endorphin; Humans; Peptide Fragments; Psychiatric Status Rating Scales; Psychotic Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Schizophrenia; Schizophrenic Psychology | 1981 |