gamma-endorphin--des-tyr(1)- and Body-Weight

gamma-endorphin--des-tyr(1)- has been researched along with Body-Weight* in 1 studies

Other Studies

1 other study(ies) available for gamma-endorphin--des-tyr(1)- and Body-Weight

ArticleYear
Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice.
    The European journal of neuroscience, 2003, Volume: 18, Issue:8

    Sigma (sigma) sites are a type of nonopiate receptor whose role has been associated with several behaviours, including anxiety, depression, analgesia, learning processes and psychosis. Although there are several known sigma receptor types, only the type I receptor (sigma 1) has been cloned. To uncover the in vivo relevance of sigma-receptors, we have generated knockout mice for sigma 1. Despite the broad expression pattern found for the sigma 1-gene, homozygous mutant mice are viable, fertile and do not display any overt phenotype, compared with their wild-type litter-mates, in mixed genetic backgrounds. However, a significant decrease in the hypermotility response has been measured in knockout mice upon challenge with (+)SKF-10 047, in agreement with the involvement of sigma 1-receptors in the induction of psychostimulant actions. The activity of sigma 2-receptors seems to be unaffected in sigma 1-mutant mice. These knockout mice could contribute to better understand the in vivo role of sigma-receptors.

    Topics: Animals; Animals, Newborn; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Binding, Competitive; Blotting, Northern; Blotting, Southern; Blotting, Western; Body Weight; Cells, Cultured; Embryo, Mammalian; Endorphins; Heterozygote; Hyperkinesis; In Situ Hybridization; Mice; Mice, Knockout; Narcotic Antagonists; Oligonucleotides, Antisense; Pentazocine; Peptide Fragments; Phenazocine; Phenotype; Radioligand Assay; Receptors, sigma; Sigma-1 Receptor; Time Factors

2003