gamma-cyclodextrin and Uveitis--Anterior

Anterior uveitis is a sight-threatening inflammation inside the eyes. Conventional eye drops for anti-inflammatory therapy need to be administered frequently owing to the rapid elimination and corneal barrier. To address these issues, polypseudorotaxane hydrogels were developed by mixing Soluplus micelles (99.4 nm) and cyclodextrins solution. The optimized hydrogels exhibited shear-thinning and sustained release properties. The hydrogels exhibited higher transcorneal permeability coefficient (P

Topics: Administration, Ophthalmic; Animals; Cyclodextrins; Drug Delivery Systems; Flurbiprofen; gamma-Cyclodextrins; Hydrogels; Ophthalmic Solutions; Poloxamer; Rabbits; Rotaxanes; Uveitis, Anterior