gamma-butyrobetaine has been researched along with Atherogenesis in 5 studies
4-(trimethylammonio)butanoate : An amino-acid betaine gamma-aminobutyric acid zwitterion in which all of the hydrogens attached to the nitrogen are replaced by methyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The elevation of the levels of l-carnitine and its fatty acid esters, acylcarnitines, in tissue or plasma has been linked to the development of atherosclerosis." | 7.81 | Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis. ( Cirule, H; Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Vilskersts, R; Volska, K, 2015) |
| "l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiota-dependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway involving an atherogenic intermediate, γ-butyrobetaine (γBB)." | 5.30 | l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. ( Bartlett, D; Cody, DB; Copeland, MF; Culley, MK; Dai, HJ; DiDonato, JA; Fu, X; Garcia-Garcia, JC; Gu, X; Hazen, SL; Kirsop, J; Koeth, RA; Lam-Galvez, BR; Levison, BS; Li, L; Li, XS; Tang, WHW; Wang, Z; Wu, Y, 2019) |
| "The elevation of the levels of l-carnitine and its fatty acid esters, acylcarnitines, in tissue or plasma has been linked to the development of atherosclerosis." | 3.81 | Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis. ( Cirule, H; Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Vilskersts, R; Volska, K, 2015) |
| "L-carnitine, a nutrient in red meat, was recently reported to accelerate atherosclerosis via a metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host hepatic conversion into trimethylamine-N-oxide (TMAO)." | 3.80 | γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. ( Buffa, JA; Culley, MK; DiDonato, JA; Gregory, JC; Hazen, SL; Koeth, RA; Levison, BS; Li, L; Lusis, AJ; Org, E; Smith, JD; Tang, WHW; Wang, Z; Wu, Y, 2014) |
| "Long-term mildronate treatment decreases L-carnitine content in aortic tissues and attenuates the development of atherosclerosis in apoE/LDLR(-/-) mice." | 3.75 | Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice. ( Chlopicki, S; Dambrova, M; Grinberga, S; Kalvinsh, I; Liepinsh, E; Mateuszuk, L; Vilskersts, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koeth, RA | 2 |
| Lam-Galvez, BR | 1 |
| Kirsop, J | 1 |
| Wang, Z | 2 |
| Levison, BS | 2 |
| Gu, X | 1 |
| Copeland, MF | 1 |
| Bartlett, D | 1 |
| Cody, DB | 1 |
| Dai, HJ | 1 |
| Culley, MK | 2 |
| Li, XS | 1 |
| Fu, X | 1 |
| Wu, Y | 2 |
| Li, L | 2 |
| DiDonato, JA | 2 |
| Tang, WHW | 2 |
| Garcia-Garcia, JC | 1 |
| Hazen, SL | 2 |
| Buffa, JA | 1 |
| Gregory, JC | 1 |
| Org, E | 1 |
| Smith, JD | 1 |
| Lusis, AJ | 1 |
| Vilskersts, R | 2 |
| Kuka, J | 1 |
| Liepinsh, E | 2 |
| Makrecka-Kuka, M | 1 |
| Volska, K | 1 |
| Makarova, E | 1 |
| Sevostjanovs, E | 1 |
| Cirule, H | 1 |
| Grinberga, S | 2 |
| Dambrova, M | 2 |
| Trøseid, M | 1 |
| Hov, JR | 1 |
| Nestvold, TK | 1 |
| Thoresen, H | 1 |
| Berge, RK | 1 |
| Svardal, A | 1 |
| Lappegård, KT | 1 |
| Mateuszuk, L | 1 |
| Kalvinsh, I | 1 |
| Chlopicki, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease[NCT01731236] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2011-02-11 | Enrolling by invitation | ||
| "Plant-Based Meat vs Animal Red Meat: a Randomized Cross-over Trial"[NCT04510324] | 41 participants (Actual) | Interventional | 2020-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for gamma-butyrobetaine and Atherogenesis
| Article | Year |
|---|---|
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Hu | 2019 |
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Hu | 2019 |
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Hu | 2019 |
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Hu | 2019 |
4 other studies available for gamma-butyrobetaine and Atherogenesis
| Article | Year |
|---|---|
γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Female; Gastrointestinal Tract; Methylamines; Mice; Mi | 2014 |
Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Betaine; Carnitine; Disease Progression; Female; | 2015 |
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery.
Topics: Adult; Atherosclerosis; Bariatric Surgery; Betaine; Body Mass Index; Cardiovascular Diseases; Carnit | 2016 |
Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice.
Topics: Animals; Aorta; Atherosclerosis; Betaine; Cardiovascular Agents; Carnitine; Energy Metabolism; Femal | 2009 |