gamma-butyrobetaine has been researched along with Amyotrophic Lateral Sclerosis in 1 studies
4-(trimethylammonio)butanoate : An amino-acid betaine gamma-aminobutyric acid zwitterion in which all of the hydrogens attached to the nitrogen are replaced by methyl groups.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The carnitine concentration was significantly higher in patients than in their spouses, while there were no significant differences in the concentrations of other metabolites." | 1.56 | Changes in the concentrations of trimethylamine N-oxide (TMAO) and its precursors in patients with amyotrophic lateral sclerosis. ( Chen, L; Chen, Y; Fan, D; Zhao, M; Zheng, L, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L | 1 |
| Chen, Y | 1 |
| Zhao, M | 1 |
| Zheng, L | 1 |
| Fan, D | 1 |
1 other study available for gamma-butyrobetaine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Changes in the concentrations of trimethylamine N-oxide (TMAO) and its precursors in patients with amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Betaine; Carnitine; Choline; Female; Gastrointestinal Microbiome; Hum | 2020 |