gamma-aminobutyric acid and Vomiting studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.

Research Excerpts

Excerpt	Relevance	Reference
"Gabapentin/placebo was started the day of chemotherapy and continued through day 5 for the first chemotherapy cycle, whereas dex was titrated down on days 2-4."	6.79	Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance). ( Barton, DL; Blair, SC; Diekmann, B; Fuloria, J; Jaslowski, AJ; Kottschade, LA; Loprinzi, CL; Lyss, AP; Mazurczak, MA; Sloan, JA; Terstriep, S; Thanarajasingam, G, 2014)
"Gabapentin is a low-cost strategy to improve complete control of CINV, specially delayed CINV control."	6.77	Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. ( Carrasco, MM; Cruz, FM; da Costa Miranda, M; da Cunha Vieira, M; de Afonseca, SO; de Iracema Gomes Cubero, D; de Souza Fêde, AB; del Giglio, A; Lera, AT; Lerner, T; Pinczowski, H; Schindler, F; Taranto, P, 2012)
" Other outcomes were overall pain during well-defined mobilizations and at rest and sedation during the first 48 hours and from days 2-6, morphine use, anxiety, depression, sleep quality, and nausea, vomiting, dizziness, concentration difficulty, headache, visual disturbances, and adverse reactions."	5.20	Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study. ( Hansen, LT; Husted, H; Kehlet, H; Laursen, MB; Lunn, TH, 2015)
" The complications of vomiting, nausea, dizziness and pruritus were also compiled to assess the safety of gabapentin and pregabalin."	4.93	The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis. ( Ding, W; Mao, Y; Wu, L, 2016)
"On the basis of the current meta-analysis, gabapentin or pregabalin can decrease the cumulative morphine consumption and decrease the occurrence of nausea; however, further trials are needed to assess the efficacy of pain control by gabapentin or pregabalin."	4.93	The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis. ( Ding, W; Mao, Y; Wu, L, 2016)
"Gabapentin has shown acute postoperative analgesic effects, but the optimal dose and procedure-specific benefits vs harm have not been clarified."	2.80	Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study. ( Hansen, LT; Husted, H; Kehlet, H; Laursen, MB; Lunn, TH, 2015)
"Dizziness was more pronounced from days 2-6 in A vs C."	2.80	Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study. ( Hansen, LT; Husted, H; Kehlet, H; Laursen, MB; Lunn, TH, 2015)
"Gabapentin/placebo was started the day of chemotherapy and continued through day 5 for the first chemotherapy cycle, whereas dex was titrated down on days 2-4."	2.79	Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance). ( Barton, DL; Blair, SC; Diekmann, B; Fuloria, J; Jaslowski, AJ; Kottschade, LA; Loprinzi, CL; Lyss, AP; Mazurczak, MA; Sloan, JA; Terstriep, S; Thanarajasingam, G, 2014)
"Gabapentin is a low-cost strategy to improve complete control of CINV, specially delayed CINV control."	2.77	Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. ( Carrasco, MM; Cruz, FM; da Costa Miranda, M; da Cunha Vieira, M; de Afonseca, SO; de Iracema Gomes Cubero, D; de Souza Fêde, AB; del Giglio, A; Lera, AT; Lerner, T; Pinczowski, H; Schindler, F; Taranto, P, 2012)
"The patient was initially treated for her abdominal pain and vomiting."	1.35	Drug use in porphyria: a therapeutic dilemma. ( Jimmy, B; Jose, J; Saravu, K; Shastry, BA, 2008)

Research

Studies (13)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Baseline Adjusted Mean Daily Motherisk-PUQE Total Scores (Pregnancy-unique Quantification of Emesis and Nausea Scale) for Days 5-7

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (30.77)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (23.08)	29.6817
2010's	6 (46.15)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Guttuso, T	2
Barton, DL	1
Thanarajasingam, G	1
Sloan, JA	1
Diekmann, B	1
Fuloria, J	1
Kottschade, LA	1
Lyss, AP	1
Jaslowski, AJ	1
Mazurczak, MA	1
Blair, SC	1
Terstriep, S	1
Loprinzi, CL	1
Lunn, TH	1
Husted, H	1
Laursen, MB	1
Hansen, LT	1
Kehlet, H	1
Kottschade, L	1
Novotny, P	1
Lyss, A	1
Mazurczak, M	1
Loprinzi, C	1
Barton, D	1
Mao, Y	1
Wu, L	1
Ding, W	1
Jose, J	1
Saravu, K	1
Shastry, BA	1
Jimmy, B	1
Cruz, FM	1
de Iracema Gomes Cubero, D	1
Taranto, P	1
Lerner, T	1
Lera, AT	1
da Costa Miranda, M	1
da Cunha Vieira, M	1
de Souza Fêde, AB	1
Schindler, F	1
Carrasco, MM	1
de Afonseca, SO	1
Pinczowski, H	1
del Giglio, A	1
Mariano Da Silva, H	1
Alcantara, MC	1
Bordini, CA	1
Speciali, JG	1
Vitticore, P	1
Holloway, RG	1
Mehler, WR	1
Newton, BW	1
Maley, BE	1
Sazonova, NS	1
Balashova, EG	1
Pedersen, E	1
Arlien-Soborg, P	1
Mai, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum[NCT02163434]	Phase 2	31 participants (Actual)	Interventional	2014-06-30	Completed
Randomized Prospective Study Comparing Variable Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy[NCT05172570]	Phase 3	120 participants (Anticipated)	Interventional	2021-04-06	Recruiting
PUCE Study: Prevention of Unmitigated Chemotherapy-induced Emesis[NCT03996863]		0 participants (Actual)	Interventional	2019-08-01	Withdrawn (stopped due to Drexel Oncology was shut down a few days before first patient in.)
"Preoperative Gabapentin and Its Effects on Postoperative Analgesia in Patients Undergoing Cosmetic Breast Surgery"[NCT05997355]		100 participants (Anticipated)	Interventional	2023-09-01	Not yet recruiting
Efficacy of Olanzapine, Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer[NCT04669132]	Phase 2	50 participants (Actual)	Interventional	2020-12-17	Completed
Clinical Trial of Gabapentin in the Prevention of Nausea Ond Vomiting Induced by Chemotherapy, a Randomized, Double-blind, Placebo Controled Study[NCT01052844]	Phase 3	80 participants (Actual)	Interventional	2009-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Score range: 6-30 with higher score indicating a worse outcome. (NCT02163434)
Timeframe: 1 week

Baseline Adjusted Mean Daily Nausea Scores From the Motherisk-PUQE for Days 5-7.

Intervention	units on a scale (Mean)
Gabapentin	6.35
Metoclopramide	13.22

Score range: 2-10 with higher score indicating a worse outcome. (NCT02163434)
Timeframe: 1 week

Baseline Adjusted Mean Daily Oral Nutrition Score for Days 5-7

Intervention	units on a scale (Mean)
Gabapentin	2.01
Metoclopramide	3.69

Score range: 0-15 with higher score indicating a better outcome. (NCT02163434)
Timeframe: 1 week

Desire to Continue Therapy at Study Endpoint

Intervention	units on a scale (Mean)
Gabapentin	7.86
Metoclopramide	4.01

Scores: 0=no, 1=yes. Thus, a higher score indicates a better outcome. (NCT02163434)
Timeframe: 1 week

Global Satisfaction of Treatment at the Study Endpoint.

Intervention	units on a scale (Mean)
Gabapentin	0.67
Metoclopramide	0.14

Score range: 0-4 with higher score indicating a better outcome. (NCT02163434)
Timeframe: 1 week

Percent of Subjects Requiring Repeat iv Hydration or Hospital Admission for HG From the Outpatient Setting.

Number of Patients With Complete Response During Chemotherapy Course 1

Intervention	units on a scale (Mean)
Gabapentin	2.22
Metoclopramide	0.63

Intervention	Participants (Count of Participants)
Gabapentin	5
Metoclopramide	5

The CR was defined as no emetic episodes and no nausea episodes from day 1 to day 5 (0-120h) (NCT01052844)
Timeframe: 5 days

Number of Patients With CR During Delayed-onset Phase (24-120 Hours) After Administration of Chemotherapy Course 1

Intervention	participants (Number)
Control Group	17
Gabapentin	26

Complete response during delayed-onset phase was defined as the absence of any episode of nausea or vomiting and no use of rescue medication when occurring during the period from days 2 through 5 after chemotherapy (NCT01052844)
Timeframe: 6 days

Article	Year
Gabapentin's anti-nausea and anti-emetic effects: a review. Experimental brain research, 2014, Volume: 232, Issue:8 Topics: Amines; Animals; Antiemetics; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Gabapentin; gam	2014
The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis. BMC musculoskeletal disorders, 2016, 08-30, Volume: 17, Issue:1 Topics: Amines; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarboxylic Acids; Dizziness; Gabapent	2016
Observations on the connectivity of the parvicellular reticular formation with respect to a vomiting center. Brain, behavior and evolution, 1983, Volume: 23, Issue:1-2 Topics: Acetylcholinesterase; Afferent Pathways; Animals; Brain Mapping; Cats; Efferent Pathways; gamma-Amin	1983

Article	Year
Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance). Cancer, 2014, Nov-15, Volume: 120, Issue:22 Topics: Adult; Aged; Amines; Antineoplastic Agents; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug A	2014
Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study. Pain, 2015, Volume: 156, Issue:12 Topics: Aged; Aged, 80 and over; Amines; Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Cy	2015
Chemotherapy-induced nausea and vomiting: incidence and characteristics of persistent symptoms and future directions NCCTG N08C3 (Alliance). Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016, Volume: 24, Issue:6 Topics: Adult; Aged; Amines; Antiemetics; Antineoplastic Agents; Cisplatin; Cyclohexanecarboxylic Acids; Dru	2016
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:3 Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De	2012
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:3 Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De	2012
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:3 Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De	2012
Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:3 Topics: Amines; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclohexanecarboxylic Acids; De	2012

Article	Year
Drug use in porphyria: a therapeutic dilemma. Singapore medical journal, 2008, Volume: 49, Issue:10 Topics: Abdominal Pain; Adult; Amines; Anticonvulsants; Antiemetics; Antihypertensive Agents; Chest Pain; Cy	2008
Strictly unilateral headache reminiscent of hemicrania continua resistant to indomethacin but responsive to gabapentin. Cephalalgia : an international journal of headache, 2002, Volume: 22, Issue:5 Topics: Acetates; Adult; Amines; Anti-Inflammatory Agents, Non-Steroidal; Blepharoptosis; Cyclohexanecarboxy	2002
Responsiveness of life-threatening refractory emesis to gabapentin-scopolamine therapy following posterior fossa surgery. Case report. Journal of neurosurgery, 2005, Volume: 102, Issue:3 Topics: Amines; Antiemetics; Cholesteatoma; Cranial Fossa, Posterior; Cyclohexanecarboxylic Acids; Drug Ther	2005
A comparison of GABA- and GAD-like immunoreactivity within the area postrema of the rat and cat. The Journal of comparative neurology, 1987, Jan-08, Volume: 255, Issue:2 Topics: Animals; Cats; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Immunoenzyme Techniques; Male; Medu	1987
[Experience with clinical use of the drug gammalon in children with cerebral palsy]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:10 Topics: Adolescent; Aminobutyrates; Cerebral Palsy; Child; Child, Preschool; Electromyography; Feeding and E	1974
The mode of action of the gaba derivative baclofen in human spasticy. Acta neurologica Scandinavica, 1974, Volume: 50, Issue:6 Topics: Achilles Tendon; Aminobutyrates; Depression, Chemical; gamma-Aminobutyric Acid; Humans; Multiple Scl	1974

gamma-aminobutyric acid and Vomiting