gamma-aminobutyric acid has been researched along with Visceral Pain in 13 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Visceral Pain: Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To identify electroencephalographic (EEG) biomarkers for the analgesic effect of pregabalin in patients with chronic visceral pain." | 9.16 | The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices. ( Bouwense, SA; Drewes, AM; Farina, D; Graversen, C; Olesen, AE; Olesen, SS; Steimle, K; van Goor, H; Wilder-Smith, OH, 2012) |
| "To assess the antinociceptive effect of pregabalin on experimental gut pain in patients with visceral hyperalgesia due to chronic pancreatitis and to reveal putative changes in corresponding central pain processing as assessed by evoked brain potentials." | 9.15 | Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. ( Drewes, AM; Frøkjaer, JB; Graversen, C; Olesen, AE; Olesen, SS; Valeriani, M; van Goor, H; Wilder-Smith, O, 2011) |
| "Pregabalin was superior to placebo for attenuation of experimental visceral pain in chronic pancreatitis patients." | 9.15 | Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. ( Drewes, AM; Frøkjaer, JB; Graversen, C; Olesen, AE; Olesen, SS; Valeriani, M; van Goor, H; Wilder-Smith, O, 2011) |
| " This study was performed to compare the potency of gabapentin, pregabalin, and morphine in a well-established model of visceral pain." | 7.79 | Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. ( Keyhanfar, F; Shamsi Meymandi, M, 2013) |
| " The anticonvulsant gabapentin, which is widely used as an analgesic agent, also reduces anxiety." | 7.77 | The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity. ( Coelho, AM; Cryan, JF; Dinan, TG; Fitzgerald, P; Lee, K; O' Mahony, SM; Winchester, W, 2011) |
| " The effective doses, for 20%, 50%, and 80% response (ED(20), ED(50), and ED(80), respectively), of each drug were calculated using least squares linear regression analysis, and then dose-response curves were compared." | 5.39 | Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. ( Keyhanfar, F; Shamsi Meymandi, M, 2013) |
| " No difference was observed between slopes of dose-response curves." | 5.39 | Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. ( Keyhanfar, F; Shamsi Meymandi, M, 2013) |
| "In this animal model of visceral pain, all three drugs exhibited parallel dose-response curves." | 5.39 | Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. ( Keyhanfar, F; Shamsi Meymandi, M, 2013) |
| "To identify electroencephalographic (EEG) biomarkers for the analgesic effect of pregabalin in patients with chronic visceral pain." | 5.16 | The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices. ( Bouwense, SA; Drewes, AM; Farina, D; Graversen, C; Olesen, AE; Olesen, SS; Steimle, K; van Goor, H; Wilder-Smith, OH, 2012) |
| "To assess the antinociceptive effect of pregabalin on experimental gut pain in patients with visceral hyperalgesia due to chronic pancreatitis and to reveal putative changes in corresponding central pain processing as assessed by evoked brain potentials." | 5.15 | Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. ( Drewes, AM; Frøkjaer, JB; Graversen, C; Olesen, AE; Olesen, SS; Valeriani, M; van Goor, H; Wilder-Smith, O, 2011) |
| "Pregabalin was superior to placebo for attenuation of experimental visceral pain in chronic pancreatitis patients." | 5.15 | Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. ( Drewes, AM; Frøkjaer, JB; Graversen, C; Olesen, AE; Olesen, SS; Valeriani, M; van Goor, H; Wilder-Smith, O, 2011) |
| " This study was performed to compare the potency of gabapentin, pregabalin, and morphine in a well-established model of visceral pain." | 3.79 | Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. ( Keyhanfar, F; Shamsi Meymandi, M, 2013) |
| " The anticonvulsant gabapentin, which is widely used as an analgesic agent, also reduces anxiety." | 3.77 | The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity. ( Coelho, AM; Cryan, JF; Dinan, TG; Fitzgerald, P; Lee, K; O' Mahony, SM; Winchester, W, 2011) |
| "Recurrent abdominal pain is a common and costly health-care problem attributed, in part, to visceral hypersensitivity." | 1.46 | GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine. ( Dann, SM; Engler, DA; Fu, Y; Hollister, EB; Johnson, C; Lugo, M; Luk, B; Major, A; Matsunami, RK; Mori-Akiyama, Y; Oezguen, N; Pokusaeva, K; Savidge, T; Shi, XZ; Uribe, G; Versalovic, J, 2017) |
| " The effective doses, for 20%, 50%, and 80% response (ED(20), ED(50), and ED(80), respectively), of each drug were calculated using least squares linear regression analysis, and then dose-response curves were compared." | 1.39 | Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. ( Keyhanfar, F; Shamsi Meymandi, M, 2013) |
| " No difference was observed between slopes of dose-response curves." | 1.39 | Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. ( Keyhanfar, F; Shamsi Meymandi, M, 2013) |
| "In this animal model of visceral pain, all three drugs exhibited parallel dose-response curves." | 1.39 | Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. ( Keyhanfar, F; Shamsi Meymandi, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (92.31) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Laroute, V | 1 |
| Beaufrand, C | 1 |
| Gomes, P | 1 |
| Nouaille, S | 1 |
| Tondereau, V | 1 |
| Daveran-Mingot, ML | 1 |
| Theodorou, V | 1 |
| Eutamene, H | 1 |
| Mercier-Bonin, M | 1 |
| Cocaign-Bousquet, M | 1 |
| Zhang, MM | 2 |
| Liu, SB | 1 |
| Chen, T | 2 |
| Koga, K | 1 |
| Zhang, T | 1 |
| Li, YQ | 2 |
| Zhuo, M | 1 |
| Li, J | 1 |
| Tu, K | 1 |
| Wang, J | 1 |
| Feng, B | 1 |
| Zhang, ZN | 1 |
| Lei, J | 1 |
| Du, JQ | 1 |
| Tang, D | 1 |
| Qian, AH | 1 |
| Song, DD | 1 |
| Ben, QW | 1 |
| Yao, WY | 1 |
| Sun, J | 1 |
| Li, WG | 1 |
| Xu, TL | 1 |
| Yuan, YZ | 1 |
| Zhang, YB | 1 |
| Guo, ZD | 1 |
| Li, MY | 1 |
| Fong, P | 1 |
| Zhang, JG | 1 |
| Zhang, CW | 1 |
| Gong, KR | 1 |
| Yang, MF | 1 |
| Niu, JZ | 1 |
| Ji, XM | 1 |
| Lv, GW | 1 |
| Pokusaeva, K | 1 |
| Johnson, C | 1 |
| Luk, B | 1 |
| Uribe, G | 1 |
| Fu, Y | 1 |
| Oezguen, N | 1 |
| Matsunami, RK | 1 |
| Lugo, M | 1 |
| Major, A | 1 |
| Mori-Akiyama, Y | 1 |
| Hollister, EB | 1 |
| Dann, SM | 1 |
| Shi, XZ | 1 |
| Engler, DA | 1 |
| Savidge, T | 1 |
| Versalovic, J | 1 |
| O' Mahony, SM | 1 |
| Coelho, AM | 1 |
| Fitzgerald, P | 1 |
| Lee, K | 1 |
| Winchester, W | 1 |
| Dinan, TG | 1 |
| Cryan, JF | 1 |
| Sikandar, S | 2 |
| Dickenson, AH | 2 |
| Olesen, SS | 2 |
| Graversen, C | 2 |
| Olesen, AE | 2 |
| Frøkjaer, JB | 1 |
| Wilder-Smith, O | 1 |
| van Goor, H | 2 |
| Valeriani, M | 1 |
| Drewes, AM | 2 |
| Steimle, K | 1 |
| Farina, D | 1 |
| Wilder-Smith, OH | 1 |
| Bouwense, SA | 1 |
| Harrington, AM | 1 |
| Brierley, SM | 1 |
| Isaacs, N | 1 |
| Hughes, PA | 1 |
| Castro, J | 1 |
| Blackshaw, LA | 1 |
| Bannister, K | 1 |
| Shamsi Meymandi, M | 1 |
| Keyhanfar, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Clinical and Experimental Pilot Study of Pregabalin in Patients With Chronic Pancreatitis[NCT00755573] | Phase 2/Phase 3 | 64 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for gamma-aminobutyric acid and Visceral Pain
| Article | Year |
|---|---|
Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis.
Topics: Adult; Aged; Analgesics; Brain Mapping; Cerebral Cortex; Double-Blind Method; Electric Stimulation; | 2011 |
The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices.
Topics: Adult; Analgesics; Chronic Pain; Dose-Response Relationship, Drug; Double-Blind Method; Electroencep | 2012 |
11 other studies available for gamma-aminobutyric acid and Visceral Pain
| Article | Year |
|---|---|
Topics: Analgesics; Animals; gamma-Aminobutyric Acid; Humans; Irritable Bowel Syndrome; Lactococcus lactis; | 2022 |
Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain.
Topics: Adenosine Triphosphate; Amines; Animals; Anxiety; Behavior, Animal; Cyclohexanecarboxylic Acids; Gab | 2014 |
The excitatory synaptic transmission of the nucleus of solitary tract was potentiated by chronic myocardial infarction in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Postsyn | 2015 |
Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasis in a rat model of visceral hypersensitivity.
Topics: Animals; Behavior, Animal; Carboxylic Acids; Chlorides; Disease Models, Animal; Down-Regulation; GAB | 2015 |
Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amines; Animals; Behavior, Animal; Cell Membrane; Cyc | 2015 |
GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine.
Topics: Abdominal Pain; Animals; Base Sequence; Bifidobacterium; Cell Line; Feces; gamma-Aminobutyric Acid; | 2017 |
The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity.
Topics: Amines; Animals; Anxiety; Comorbidity; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; | 2011 |
Pregabalin modulation of spinal and brainstem visceral nociceptive processing.
Topics: Afferent Pathways; Analgesics; Animals; Brain Stem; Disease Models, Animal; gamma-Aminobutyric Acid; | 2011 |
Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity.
Topics: Afferent Pathways; Analysis of Variance; Animals; Calbindins; Calcitonin Gene-Related Peptide; Chole | 2012 |
Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats.
Topics: Analgesics; Animals; Brain Stem; Efferent Pathways; gamma-Aminobutyric Acid; Long-Term Potentiation; | 2012 |
Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain.
Topics: Acetic Acid; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Cycloh | 2013 |