gamma-aminobutyric acid has been researched along with Trigeminal Neuralgia in 50 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Trigeminal Neuralgia: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of pregabalin (PGB) on patient-reported health outcomes were assessed in 65 PGB-naive subjects with trigeminal neuralgia refractory to previous analgesic therapy in a prospective, multicentre observational study carried out in primary care." | 9.14 | Patient-reported outcomes in subjects with painful trigeminal neuralgia receiving pregabalin: evidence from medical practice in primary care settings. ( Martínez, S; Navarro, A; Pérez, C; Rejas, J; Saldaña, MT, 2009) |
| "A large case series of patients with centrally mediated pain, peripherally mediated pain, migraine, and tremor were treated in an open-label study with gabapentin (maximum of 2,700 mg/day)." | 9.08 | Gabapentin for treatment of pain and tremor: a large case series. ( Merren, MD, 1998) |
| "Gabapentin offers an effective, safe alternative therapy or co-therapy for the listed painful conditions and tremor; it does not affect the metabolism of other medications and is well tolerated." | 9.08 | Gabapentin for treatment of pain and tremor: a large case series. ( Merren, MD, 1998) |
| "The aim of this systematic review was to determine the efficacy of gabapentin (GBP) in the treatment of pain of idiopathic trigeminal neuralgia (TN)." | 9.01 | Efficacy of gabapentin in the treatment of trigeminal neuralgia: A systematic review of randomized controlled trials. ( Ariyawardana, A; Dinh, HQ; Lin, S; Nguyen, K; Ong, YL; Ta, PCP, 2019) |
| "Gabapentin, which has been approved for add-on therapy of focal seizures, is increasingly used for treatment of neuropathic pain." | 8.81 | [Gabapentin therapy for pain]. ( Block, F, 2001) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "The purpose of this study is to analyze the effect of pregabalin (PGB) on pain alleviation, use of health care and non-health care resources, and associated costs in patients with trigeminal neuralgia under usual clinical practice in primary care settings." | 7.75 | Trigeminal neuralgia treated with pregabalin in family medicine settings: its effect on pain alleviation and cost reduction. ( Martínez, S; Navarro, A; Pérez, C; Rejas, J; Saldaña, MT, 2009) |
| "This prospective, open-label study aimed to evaluate the efficacy of pregabalin treatment in patients suffering from trigeminal neuralgia with and without concomitant facial pain." | 7.74 | Efficacy of pregabalin in the treatment of trigeminal neuralgia. ( Diener, HC; Katsarava, Z; Maschke, M; Obermann, M; Sensen, K; Yoon, MS, 2008) |
| "This report describes the effectiveness of gabapentin, a recently approved anticonvulsant, in seven patients with MS experiencing trigeminal neuralgia refractory to treatment with conventional medical therapy." | 7.70 | Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients. ( Khan, OA, 1998) |
| " We report 11 MS patients with trigeminal neuralgia (TN): 6 intolerant to a therapeutic dosage of CBZ, showing serious adverse effects and subsequently treated with a combination of low-dose CBZ and gabapentin (GBP) (group 1); 5 treated with lamotrigine (LMT), showing adverse effects and subsequently treated with GBP (group 2)." | 7.70 | Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. ( Leandri, M; Mancardi, GL; Messmer Uccelli, M; Solaro, C; Uccelli, A, 2000) |
| "Gabapentin, which has been approved for add-on therapy of focal seizures, is increasingly used for treatment of neuropathic pain." | 6.41 | [Gabapentin therapy for pain]. ( Block, F, 2001) |
| "Patients without concomitant facial pain showed better response rates (32 of 39, 82%) compared with patients with concomitant chronic facial pain (7 of 14, 50%, P = 0." | 5.35 | Efficacy of pregabalin in the treatment of trigeminal neuralgia. ( Diener, HC; Katsarava, Z; Maschke, M; Obermann, M; Sensen, K; Yoon, MS, 2008) |
| "Trigeminal neuralgia is sudden, usually unilateral, severe, stabbing, brief recurrent pain in the distribution area of one or more of the branches of trigeminal nerve." | 5.35 | Gabapentin for refractory idiopathic trigeminal neuralgia. ( Pandey, CK; Singh, N; Singh, PK, 2008) |
| "Here a case of idiopathic trigeminal neuralgia is presented." | 5.35 | Gabapentin for refractory idiopathic trigeminal neuralgia. ( Pandey, CK; Singh, N; Singh, PK, 2008) |
| " We report 11 MS patients with trigeminal neuralgia (TN): 6 intolerant to a therapeutic dosage of CBZ, showing serious adverse effects and subsequently treated with a combination of low-dose CBZ and gabapentin (GBP) (group 1); 5 treated with lamotrigine (LMT), showing adverse effects and subsequently treated with GBP (group 2)." | 5.31 | Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. ( Leandri, M; Mancardi, GL; Messmer Uccelli, M; Solaro, C; Uccelli, A, 2000) |
| "Effects of pregabalin (PGB) on patient-reported health outcomes were assessed in 65 PGB-naive subjects with trigeminal neuralgia refractory to previous analgesic therapy in a prospective, multicentre observational study carried out in primary care." | 5.14 | Patient-reported outcomes in subjects with painful trigeminal neuralgia receiving pregabalin: evidence from medical practice in primary care settings. ( Martínez, S; Navarro, A; Pérez, C; Rejas, J; Saldaña, MT, 2009) |
| "A large case series of patients with centrally mediated pain, peripherally mediated pain, migraine, and tremor were treated in an open-label study with gabapentin (maximum of 2,700 mg/day)." | 5.08 | Gabapentin for treatment of pain and tremor: a large case series. ( Merren, MD, 1998) |
| "Gabapentin offers an effective, safe alternative therapy or co-therapy for the listed painful conditions and tremor; it does not affect the metabolism of other medications and is well tolerated." | 5.08 | Gabapentin for treatment of pain and tremor: a large case series. ( Merren, MD, 1998) |
| "The aim of this systematic review was to determine the efficacy of gabapentin (GBP) in the treatment of pain of idiopathic trigeminal neuralgia (TN)." | 5.01 | Efficacy of gabapentin in the treatment of trigeminal neuralgia: A systematic review of randomized controlled trials. ( Ariyawardana, A; Dinh, HQ; Lin, S; Nguyen, K; Ong, YL; Ta, PCP, 2019) |
| "Gabapentin, which has been approved for add-on therapy of focal seizures, is increasingly used for treatment of neuropathic pain." | 4.81 | [Gabapentin therapy for pain]. ( Block, F, 2001) |
| " Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats." | 3.85 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "The antiepileptic drugs carbamazepine and gabapentin are effective in treating neuropathic pain and trigeminal neuralgia." | 3.81 | Effect of carbamazepine and gabapentin on excitability in the trigeminal subnucleus caudalis of neonatal rats using a voltage-sensitive dye imaging technique. ( Arisaka, H; Hosokawa, Y; Kaku, Y; Kuwana, S; Matsumoto, A; Sakuraba, S; Sugita, T; Umezawa, N; Yoshida, K, 2015) |
| " In our article, we report two sisters, one of whom was treated with levothyroxine because of hypothyroidism." | 3.80 | Transient hypothyroidism induced by anticonvulsant agents. ( Krysiak, R; Stojko, R, 2014) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "The present study showed that the administration of multidrug regimens is a useful alternative in controlling trigeminal neuralgia in patients who are unable to tolerate higher doses of carbamazepine." | 3.78 | Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution. ( Ariyawardana, A; Pallegama, R; Ranasinghe, A; Sitheeque, M, 2012) |
| "The purpose of this study is to analyze the effect of pregabalin (PGB) on pain alleviation, use of health care and non-health care resources, and associated costs in patients with trigeminal neuralgia under usual clinical practice in primary care settings." | 3.75 | Trigeminal neuralgia treated with pregabalin in family medicine settings: its effect on pain alleviation and cost reduction. ( Martínez, S; Navarro, A; Pérez, C; Rejas, J; Saldaña, MT, 2009) |
| "This prospective, open-label study aimed to evaluate the efficacy of pregabalin treatment in patients suffering from trigeminal neuralgia with and without concomitant facial pain." | 3.74 | Efficacy of pregabalin in the treatment of trigeminal neuralgia. ( Diener, HC; Katsarava, Z; Maschke, M; Obermann, M; Sensen, K; Yoon, MS, 2008) |
| "Carbamazepine is still the main drug of choice in the management of trigeminal neuralgia." | 3.74 | Prescription pattern of oral healthcare professionals in the use of anticonvulsants for trigeminal neuralgia. ( Fei, YJ; Hon, NC, 2008) |
| " We report 11 MS patients with trigeminal neuralgia (TN): 6 intolerant to a therapeutic dosage of CBZ, showing serious adverse effects and subsequently treated with a combination of low-dose CBZ and gabapentin (GBP) (group 1); 5 treated with lamotrigine (LMT), showing adverse effects and subsequently treated with GBP (group 2)." | 3.70 | Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. ( Leandri, M; Mancardi, GL; Messmer Uccelli, M; Solaro, C; Uccelli, A, 2000) |
| "This report describes the effectiveness of gabapentin, a recently approved anticonvulsant, in seven patients with MS experiencing trigeminal neuralgia refractory to treatment with conventional medical therapy." | 3.70 | Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients. ( Khan, OA, 1998) |
| "Trigeminal neuralgia is a unique neuropathic pain disorder with a specific therapy." | 2.42 | Management issues of neuropathic trigeminal pain from a medical perspective. ( Watson, CP, 2004) |
| "Gabapentin, which has been approved for add-on therapy of focal seizures, is increasingly used for treatment of neuropathic pain." | 2.41 | [Gabapentin therapy for pain]. ( Block, F, 2001) |
| "Among the more common symptoms is spasticity." | 2.41 | Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis. ( Schapiro, RT, 2001) |
| "A rodent model of trigeminal neuropathic pain was first developed in 1994, in which chronic constriction injury (CCI) is induced by ligation of the infraorbital nerve (IoN)." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "However, studies on trigeminal neuropathic pain remain limited." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "Carbamazepine was the drug used in 36 patients." | 1.38 | Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution. ( Ariyawardana, A; Pallegama, R; Ranasinghe, A; Sitheeque, M, 2012) |
| " The dosage was adjusted according to the level of pain control and side-effects." | 1.38 | Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution. ( Ariyawardana, A; Pallegama, R; Ranasinghe, A; Sitheeque, M, 2012) |
| "The short height and the reported bone fractures could be compatible with a mild form of osteogenesis imperfecta, previously described in one case associated with SUNCT." | 1.35 | SUNCT syndrome or first division trigeminal neuralgia associated with cerebellar hypoplasia. ( Bartolozzi, ML; Guidi, L; Panconesi, A, 2009) |
| "Here a case of idiopathic trigeminal neuralgia is presented." | 1.35 | Gabapentin for refractory idiopathic trigeminal neuralgia. ( Pandey, CK; Singh, N; Singh, PK, 2008) |
| "Gabapentin was used in 20% of the subjects." | 1.35 | Prescription pattern of oral healthcare professionals in the use of anticonvulsants for trigeminal neuralgia. ( Fei, YJ; Hon, NC, 2008) |
| "Patients without concomitant facial pain showed better response rates (32 of 39, 82%) compared with patients with concomitant chronic facial pain (7 of 14, 50%, P = 0." | 1.35 | Efficacy of pregabalin in the treatment of trigeminal neuralgia. ( Diener, HC; Katsarava, Z; Maschke, M; Obermann, M; Sensen, K; Yoon, MS, 2008) |
| "Trigeminal neuralgia is sudden, usually unilateral, severe, stabbing, brief recurrent pain in the distribution area of one or more of the branches of trigeminal nerve." | 1.35 | Gabapentin for refractory idiopathic trigeminal neuralgia. ( Pandey, CK; Singh, N; Singh, PK, 2008) |
| "Neuropathic and/or neuralgic facial pain occurred in 50% (n = 7)." | 1.35 | The trigeminal trophic syndrome: an unusual cause of face pain, dysaesthesias, anaesthesia and skin/soft tissue lesions. ( Garza, I, 2008) |
| " We report 11 MS patients with trigeminal neuralgia (TN): 6 intolerant to a therapeutic dosage of CBZ, showing serious adverse effects and subsequently treated with a combination of low-dose CBZ and gabapentin (GBP) (group 1); 5 treated with lamotrigine (LMT), showing adverse effects and subsequently treated with GBP (group 2)." | 1.31 | Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. ( Leandri, M; Mancardi, GL; Messmer Uccelli, M; Solaro, C; Uccelli, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.00) | 18.7374 |
| 1990's | 4 (8.00) | 18.2507 |
| 2000's | 24 (48.00) | 29.6817 |
| 2010's | 20 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ta, PCP | 1 |
| Dinh, HQ | 1 |
| Nguyen, K | 1 |
| Lin, S | 1 |
| Ong, YL | 1 |
| Ariyawardana, A | 2 |
| Kumar, N | 1 |
| Cherkas, PS | 1 |
| Varathan, V | 1 |
| Miyamoto, M | 1 |
| Chiang, CY | 2 |
| Dostrovsky, JO | 2 |
| Sessle, BJ | 2 |
| Coderre, TJ | 1 |
| Kim, JB | 1 |
| Yu, S | 1 |
| López-López, J | 1 |
| Estrugo-Devesa, A | 1 |
| Jane-Salas, E | 1 |
| Segura-Egea, JJ | 1 |
| Chang, TI | 1 |
| Gunathilake, R | 1 |
| Boyce, LE | 1 |
| Knight, AT | 1 |
| Haviv, Y | 1 |
| Zadik, Y | 1 |
| Sharav, Y | 1 |
| Benoliel, R | 1 |
| Oshinsky, ML | 1 |
| Murphy, AL | 1 |
| Hekierski, H | 1 |
| Cooper, M | 1 |
| Simon, BJ | 1 |
| Dieb, W | 1 |
| Hafidi, A | 1 |
| Krysiak, R | 1 |
| Stojko, R | 1 |
| Hummig, W | 1 |
| Kopruszinski, CM | 1 |
| Chichorro, JG | 1 |
| Abdallah, K | 1 |
| Monconduit, L | 1 |
| Artola, A | 1 |
| Luccarini, P | 1 |
| Dallel, R | 1 |
| Matsumoto, A | 1 |
| Arisaka, H | 1 |
| Hosokawa, Y | 1 |
| Sakuraba, S | 1 |
| Sugita, T | 1 |
| Umezawa, N | 1 |
| Kaku, Y | 1 |
| Yoshida, K | 1 |
| Kuwana, S | 1 |
| Gill, I | 1 |
| Parrent, AG | 1 |
| Steven, DA | 1 |
| Ding, W | 1 |
| You, Z | 1 |
| Shen, S | 1 |
| Yang, J | 1 |
| Lim, G | 1 |
| Doheny, JT | 1 |
| Chen, L | 1 |
| Zhu, S | 1 |
| Mao, J | 1 |
| Garza, I | 1 |
| De Cesaris, F | 1 |
| Fanciullacci, M | 1 |
| Pietrini, U | 1 |
| Anselmi, B | 1 |
| Del Bene, E | 1 |
| Pandey, CK | 1 |
| Singh, N | 1 |
| Singh, PK | 1 |
| Viel, M | 1 |
| Pérez, C | 2 |
| Saldaña, MT | 2 |
| Navarro, A | 2 |
| Martínez, S | 2 |
| Rejas, J | 2 |
| Panconesi, A | 1 |
| Bartolozzi, ML | 1 |
| Guidi, L | 1 |
| Marziniak, M | 1 |
| Breyer, R | 1 |
| Evers, S | 1 |
| Scrivani, S | 1 |
| Wallin, D | 1 |
| Moulton, EA | 1 |
| Cole, S | 1 |
| Wasan, AD | 1 |
| Lockerman, L | 1 |
| Bajwa, Z | 1 |
| Upadhyay, J | 1 |
| Becerra, L | 1 |
| Borsook, D | 1 |
| Nakamizo, S | 1 |
| Miyachi, Y | 1 |
| Kabashima, K | 1 |
| Martin, WJ | 1 |
| Forouzanfar, T | 1 |
| Hon, NC | 1 |
| Fei, YJ | 1 |
| Pallegama, R | 1 |
| Sitheeque, M | 1 |
| Ranasinghe, A | 1 |
| Flickinger, JC | 2 |
| Kim, H | 1 |
| Kano, H | 1 |
| Greenberger, JS | 1 |
| Arai, Y | 1 |
| Niranjan, A | 1 |
| Lunsford, LD | 1 |
| Kondziolka, D | 1 |
| Cao, Y | 1 |
| Wang, H | 1 |
| Vitek, L | 1 |
| Tettenborn, B | 1 |
| Levin, M | 1 |
| Ward, TN | 1 |
| Larson, E | 1 |
| Hänsel, A | 1 |
| Watson, CP | 1 |
| Braune, S | 1 |
| Berthele, A | 1 |
| Tölle, TR | 1 |
| Horvath, J | 1 |
| Coeytaux, A | 1 |
| Jallon, P | 1 |
| Landis, T | 1 |
| Temperli, P | 1 |
| Burkhard, PR | 1 |
| Felicio, AC | 1 |
| Godeiro, Cde O | 1 |
| Borges, V | 1 |
| Silva, SM | 1 |
| Ferraz, HB | 1 |
| Obermann, M | 1 |
| Yoon, MS | 1 |
| Sensen, K | 1 |
| Maschke, M | 1 |
| Diener, HC | 1 |
| Katsarava, Z | 1 |
| Lemos, L | 1 |
| Flores, S | 1 |
| Oliveira, P | 1 |
| Almeida, A | 1 |
| Sist, T | 1 |
| Filadora, V | 1 |
| Miner, M | 1 |
| Lema, M | 1 |
| Carrazana, EJ | 1 |
| Schachter, SC | 1 |
| Khan, OA | 1 |
| Merren, MD | 1 |
| Solaro, C | 1 |
| Messmer Uccelli, M | 1 |
| Uccelli, A | 1 |
| Leandri, M | 1 |
| Mancardi, GL | 1 |
| Fischoff, DK | 1 |
| Sirois, D | 1 |
| Block, F | 1 |
| Christensen, D | 1 |
| Gautron, M | 1 |
| Guilbaud, G | 1 |
| Kayser, V | 1 |
| Schapiro, RT | 1 |
| Karlov, VA | 2 |
| Megdiatov, RS | 1 |
| Megdiatova, RS | 1 |
| Vlasenko, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage[NCT04126408] | 40 participants (Actual) | Interventional | 2020-01-13 | Completed | |||
| The Effect Of Transcutaneous Auricular Vagus Nerve Stimulation On Sports Performance And Physiological Parameters In Healthy Young Individuals: Randomized, Double-Blind Study[NCT04768738] | 46 participants (Actual) | Interventional | 2020-02-01 | Completed | |||
| Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI[NCT00243152] | 6 participants (Actual) | Interventional | 2005-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
fMRI scans acquired Stimuli Type: Brush Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness fMRI scans acquired Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** fMRI scans acquired Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** Cortical, subcortical, and brain stem sensory regions Z-scores Increase or decrease in activation as affected by the drug (NCT00243152)
Timeframe: Week 10 during scanning session
| Intervention | Z-statistic (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Heat Affected Thalamus (10,-14,8) | Heat Affected Post-Central (-56,-12,28) | Cold Affected Post-Central (68, -8, 32) | Cold Affected Thalamus (-4, -8, 0) | Brush Affected Post-Central (66,-16,14) | Brush Affected Thalamus (-14,-22, 4) | Brush Affected Spinal Trigeminal Nucles(2,-48,-68) | |
| Lamotrigine vs Placebo | -2.9294 | -2.7323 | -2.5114 | -3.033 | 3.905 | -3.791 | 2.9058 |
"Quantitative Sensory Testing (QST)~Stimuli Type: Heat, Cold, Brush Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness~Ratings on a likert scale of 0-10 with 0 being defined as no pain and 10 being defined as worst possible pain" (NCT00243152)
Timeframe: week 10 (during the scan)
| Intervention | scores on a pain scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Heat Affected | Heat Unaffected | Cold Affected | Cold Unaffected | Brush Affected | Brush Unaffected | |
| Lamotrigine | 3.2 | 3 | 2.1 | 2.2 | 2.8 | 1.2 |
| Placebo | 5.5 | 4 | 2.5 | 1.1 | 3.9 | .4 |
7 reviews available for gamma-aminobutyric acid and Trigeminal Neuralgia
| Article | Year |
|---|---|
Efficacy of gabapentin in the treatment of trigeminal neuralgia: A systematic review of randomized controlled trials.
Topics: Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; | 2019 |
The efficacy of anticonvulsants on orofacial pain: a systematic review.
Topics: Amines; Anticonvulsants; Burning Mouth Syndrome; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Ac | 2011 |
Management issues of neuropathic trigeminal pain from a medical perspective.
Topics: Amines; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; C | 2004 |
[Evidence-based pharmacotherapy of neuropathic pain syndromes].
Topics: Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Antioxidants; Cyclohexanec | 2004 |
Painful trigeminal neuropathy caused by severe mandibular resorption and nerve compression in a patient with systemic sclerosis: case report and literature review.
Topics: Acetates; Adult; Amines; Analgesics; Anticonvulsants; Bone Resorption; CREST Syndrome; Cyclohexaneca | 2000 |
[Gabapentin therapy for pain].
Topics: Acetates; Amines; Analgesics; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Diabetic Neurop | 2001 |
Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis.
Topics: Acetates; Amines; Autoimmune Diseases; Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Cannabin | 2001 |
5 trials available for gamma-aminobutyric acid and Trigeminal Neuralgia
| Article | Year |
|---|---|
GABAAergic inhibition or dopamine denervation of the A11 hypothalamic nucleus induces trigeminal analgesia.
Topics: Animals; Calcitonin Gene-Related Peptide; Denervation; Dopamine; Dorsomedial Hypothalamic Nucleus; F | 2015 |
Patient-reported outcomes in subjects with painful trigeminal neuralgia receiving pregabalin: evidence from medical practice in primary care settings.
Topics: Analgesics; Disability Evaluation; Evidence-Based Medicine; Female; gamma-Aminobutyric Acid; Humans; | 2009 |
A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study.
Topics: Adult; Amines; Anticonvulsants; Brain; Cold Temperature; Cross-Over Studies; Cyclohexanecarboxylic A | 2010 |
Gabapentin supplemented with ropivacain block of trigger points improves pain control and quality of life in trigeminal neuralgia patients when compared with gabapentin alone.
Topics: Acetaminophen; Amides; Amines; Analgesics; Analgesics, Non-Narcotic; Anesthetics, Local; Cyclohexane | 2008 |
Gabapentin for treatment of pain and tremor: a large case series.
Topics: Acetates; Adult; Aged; Amines; Analgesics; Anticonvulsants; Arachnoiditis; Cerebellar Neoplasms; Cyc | 1998 |
38 other studies available for gamma-aminobutyric acid and Trigeminal Neuralgia
| Article | Year |
|---|---|
Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain.
Topics: Analgesics; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Data Interpretation | 2013 |
Neurological picture. Trigeminal neuralgia after pontine infarction affecting the ipsilateral trigeminal nerve.
Topics: Amines; Analgesics, Non-Narcotic; Carbamazepine; Cerebral Infarction; Cyclohexanecarboxylic Acids; G | 2013 |
Medical treatment of post-dental extraction peripheral painful traumatic trigeminal neuropathy.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Diagnosis, Differential; Drug Therapy, Combination; Female | 2013 |
Pregabalin-associated rhabdomyolysis.
Topics: Aged; Analgesics; Female; gamma-Aminobutyric Acid; Humans; Pregabalin; Rhabdomyolysis; Trigeminal Ne | 2013 |
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Proto | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Mechanism of GABA involvement in post-traumatic trigeminal neuropathic pain: activation of neuronal circuitry composed of PKCγ interneurons and pERK1/2 expressing neurons.
Topics: Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Interneurons; Male; MAP Kin | 2015 |
Transient hypothyroidism induced by anticonvulsant agents.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm | 2014 |
Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Chronic Pain; Dis | 2014 |
Effect of carbamazepine and gabapentin on excitability in the trigeminal subnucleus caudalis of neonatal rats using a voltage-sensitive dye imaging technique.
Topics: Action Potentials; Afferent Pathways; Amines; Animals; Animals, Newborn; Anticonvulsants; Carbamazep | 2015 |
Trigeminal neuropathic pain as a complication of anterior temporal lobectomy: report of 2 cases.
Topics: Amines; Analgesics; Anterior Temporal Lobectomy; Cyclohexanecarboxylic Acids; Drug Resistant Epileps | 2016 |
An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Functional Lateral | 2017 |
The trigeminal trophic syndrome: an unusual cause of face pain, dysaesthesias, anaesthesia and skin/soft tissue lesions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Child; Cyclohexanecarboxylic Acids; Erythema; Fa | 2008 |
Defining neuralgiform headache with ipsilateral autonomic symptoms: case report in a headache center.
Topics: Aged; Amines; Analgesics, Opioid; Anticonvulsants; Autonomic Nervous System; Cyclohexanecarboxylic A | 2008 |
Gabapentin for refractory idiopathic trigeminal neuralgia.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Follow-Up Studies; Gabapentin; gamma-Aminob | 2008 |
Pregabalin for the treatment of trigeminal neuralgia.
Topics: Analgesics; gamma-Aminobutyric Acid; Humans; Pregabalin; Trigeminal Neuralgia | 2008 |
Trigeminal neuralgia treated with pregabalin in family medicine settings: its effect on pain alleviation and cost reduction.
Topics: Absenteeism; Analgesics; Drug Therapy, Combination; Family Practice; Female; gamma-Aminobutyric Acid | 2009 |
SUNCT syndrome or first division trigeminal neuralgia associated with cerebellar hypoplasia.
Topics: Amines; Arnold-Chiari Malformation; Carbamazepine; Cerebellum; Cranial Fossa, Posterior; Cyclohexane | 2009 |
SUNCT syndrome successfully treated with the combination of oxcarbazepine and gabapentin.
Topics: Aged; Amines; Analgesics; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Synergis | 2009 |
Treatment of neuropathic itch possibly due to trigeminal trophic syndrome with 0.1% topical tacrolimus and gabapentin.
Topics: Administration, Cutaneous; Amines; Analgesics; Antipruritics; Cyclohexanecarboxylic Acids; Drug Ther | 2010 |
Prescription pattern of oral healthcare professionals in the use of anticonvulsants for trigeminal neuralgia.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecar | 2008 |
Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution.
Topics: Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Carbamazepine; Cyclohexanecarboxy | 2012 |
Do carbamazepine, gabapentin, or other anticonvulsants exert sufficient radioprotective effects to alter responses from trigeminal neuralgia radiosurgery?
Topics: Adult; Aged; Aged, 80 and over; Amines; Analysis of Variance; Anticonvulsants; Carbamazepine; Cycloh | 2012 |
Pregabalin suppresses nociceptive behavior and central sensitization in a rat trigeminal neuropathic pain model.
Topics: Analgesics; Animals; Behavior, Animal; Cranial Nerve Injuries; Electric Stimulation; Facial Pain; ga | 2013 |
Cavernous angioma in the brachium pontis presenting with trigeminal neuralgia: a case report.
Topics: Acetates; Amines; Analgesics; Central Nervous System Vascular Malformations; Cyclohexanecarboxylic A | 2002 |
Migraine-tic syndrome: a case report of a new headache type.
Topics: Acetates; Adult; Amines; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Female; Gabapentin; g | 2004 |
[Neuritis of the maxillary nerve. A 55-year-old housewife].
Topics: Amines; Analgesics; Anti-Inflammatory Agents; Cluster Headache; Cranial Nerve Diseases; Cyclohexanec | 2004 |
[Medication, steel or radiation? The appropriate strategy to treat facial neuralgia].
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Decompression, Surgical; Diagno | 2005 |
Carbamazepine encephalopathy masquerading as Creutzfeldt-Jakob disease.
Topics: Aged; Amines; Analgesics, Non-Narcotic; Atrophy; Basal Ganglia; Brain; Brain Damage, Chronic; Carbam | 2005 |
Bilateral hemifacial spasm and trigeminal neuralgia: a unique form of painful tic convulsif.
Topics: Aged; Amines; Amitriptyline; Analgesics; Arachnoid Cysts; Botulinum Toxins, Type A; Cyclohexanecarbo | 2007 |
Efficacy of pregabalin in the treatment of trigeminal neuralgia.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; Facia | 2008 |
Gabapentin for idiopathic trigeminal neuralgia: report of two cases.
Topics: Acetates; Aged; Aged, 80 and over; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapent | 1997 |
Alternative uses of lamotrigine and gabapentin in the treatment of trigeminal neuralgia.
Topics: Acetates; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Huma | 1998 |
Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients.
Topics: Acetates; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut | 1998 |
Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Res | 2000 |
Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2001 |
[Pathogenetic therapy of trigeminal neuralgia].
Topics: Adult; Aged; gamma-Aminobutyric Acid; Humans; Middle Aged; Pantothenic Acid; Personality; Tranquiliz | 1988 |
[Changes in the psychoemotional sphere and their correction in trigeminal neuralgia].
Topics: Acute Disease; Adult; Affective Symptoms; Drug Evaluation; Drug Therapy, Combination; gamma-Aminobut | 1987 |