gamma-aminobutyric acid has been researched along with Thiamine Deficiency in 13 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Thiamine Deficiency: A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Maternal thiamine deficiency causes changes in cellular energy metabolism that can interfere with offspring brain development." | 3.76 | Maternal thiamine restriction during lactation induces cognitive impairments and changes in glutamate and GABA concentrations in brain of rat offspring. ( de Freitas-Silva, DM; Franco, GC; Pereira, SR; Resende, Lde S; Ribeiro, AM, 2010) |
| " In Wernicke-Korsakoff's syndrome (WKS) and the animal model of the disorder, pyrithiamine-induced thiamine deficiency (PTD), there is both diencephalic damage and basal forebrain cell loss that could contribute to the amnesic state." | 3.75 | The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia. ( Roland, JJ; Savage, LM, 2009) |
| "Thiamine deficiency is a recognized cause of Wernicke's encephalopathy (WE), a condition in which small necrotic lesions are found in close proximity to the third and fourth ventricles and the Sylvian aqueduct." | 2.40 | Wernicke's encephalopathy: an excitotoxicity hypothesis. ( McEntee, WJ, 1997) |
| " Neurons in the thiamine-deficient animals were more sensitive to the inhibitory effects of 5-HT, as demonstrated by a significant parallel shift to the left of the dose-response curve." | 1.27 | Enhanced sensitivity of cerebellar Purkinje cells to iontophoretically-applied serotonin in thiamine deficiency. ( Lee, RS; Strahlendorf, HK; Strahlendorf, JC, 1985) |
| "Thiamine-deficient encephalopathy in the rat is characterized by ataxic gait, loss of righting reflex and curvature of the spine." | 1.26 | Amino acid changes in thiamine-deficient encephalopathy: some implications for the pathogenesis of Friedreich's ataxia. ( Barbeau, A; Butterworth, RF; Hamel, E; Landreville, F, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferreira-Vieira, TH | 1 |
| de Freitas-Silva, DM | 2 |
| Ribeiro, AF | 1 |
| Pereira, SR | 2 |
| Ribeiro, ÂM | 2 |
| Roland, JJ | 1 |
| Savage, LM | 1 |
| Bunik, VI | 1 |
| Fernie, AR | 1 |
| Resende, Lde S | 1 |
| Franco, GC | 1 |
| MONFOORT, CH | 1 |
| Dodd, PR | 1 |
| Thomas, GJ | 1 |
| McCloskey, A | 1 |
| Crane, DI | 1 |
| Smith, ID | 1 |
| McEntee, WJ | 1 |
| Fadda, F | 1 |
| Rossetti, ZL | 1 |
| Hamel, E | 2 |
| Butterworth, RF | 2 |
| Barbeau, A | 2 |
| Landreville, F | 1 |
| Chan, AW | 1 |
| Page, MG | 1 |
| Ankoma-Sey, V | 1 |
| Coulson, WF | 1 |
| Bender, DA | 1 |
| Lee, RS | 1 |
| Strahlendorf, HK | 1 |
| Strahlendorf, JC | 1 |
3 reviews available for gamma-aminobutyric acid and Thiamine Deficiency
| Article | Year |
|---|---|
Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation.
Topics: Animals; Energy Metabolism; gamma-Aminobutyric Acid; Humans; Ketoglutarate Dehydrogenase Complex; Ke | 2009 |
Wernicke's encephalopathy: an excitotoxicity hypothesis.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Models, Neurological; Neurotoxins; T | 1997 |
Chronic ethanol consumption: from neuroadaptation to neurodegeneration.
Topics: Acetylcholine; Adaptation, Physiological; Alcohol Amnestic Disorder; Alcohol Drinking; Alcohol-Relat | 1998 |
10 other studies available for gamma-aminobutyric acid and Thiamine Deficiency
| Article | Year |
|---|---|
Perinatal thiamine restriction affects central GABA and glutamate concentrations and motor behavior of adult rat offspring.
Topics: Animals; Brain; Cerebellar Cortex; Female; gamma-Aminobutyric Acid; Glutamic Acid; Maternal-Fetal Ex | 2016 |
The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia.
Topics: Acetylcholine; Amnesia; Animals; Brain; Calbindins; Cell Death; Choline O-Acetyltransferase; Disease | 2009 |
Maternal thiamine restriction during lactation induces cognitive impairments and changes in glutamate and GABA concentrations in brain of rat offspring.
Topics: Analysis of Variance; Animals; Animals, Suckling; Brain; Cognition Disorders; Energy Metabolism; Fem | 2010 |
Restoration of acetoin and succinic semialdehyde formation in pigeon muscle homogenates impaired by thiamine deficiency.
Topics: Acetoin; Animals; Columbidae; gamma-Aminobutyric Acid; Ketones; Muscles; Succinates; Thiamine; Thiam | 1954 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Effect of thiamine deficiency on levels of putative amino acid transmitters in affected regions of the rat brain.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebellum; gamma-Aminobutyric Acid; Glutamine; Glycine; Ma | 1979 |
Amino acid changes in thiamine-deficient encephalopathy: some implications for the pathogenesis of Friedreich's ataxia.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Diseases; Friedreich Ataxia; gamma-Aminobutyric Ac | 1979 |
Combined metabolic effects of ethanol and thiamine deficiency in the central nervous system.
Topics: Adenosine Triphosphate; Animals; Brain; Ethanol; gamma-Aminobutyric Acid; Gluconates; Glucose; Gluco | 1978 |
Brain glutamate and gamma-aminobutyrate (GABA) metabolism in thiamin-deficient rats.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamates; Male; Rats; Rats, Inbred Strains; Thiamine Defi | 1989 |
Enhanced sensitivity of cerebellar Purkinje cells to iontophoretically-applied serotonin in thiamine deficiency.
Topics: Animals; Differential Threshold; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobut | 1985 |