Page last updated: 2024-10-16

gamma-aminobutyric acid and Stroke

gamma-aminobutyric acid has been researched along with Stroke in 82 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
"Pregabalin has demonstrated efficacy in several forms of neuropathic pain, but its long-term efficacy in central post-stroke pain (CPSP) is unproven."9.15Safety and efficacy of pregabalin in patients with central post-stroke pain. ( Bashford, G; Cheung, R; Dror, V; Kim, JS; Martin, A; Murphy, KT, 2011)
"The study was designed to compare the efficacy of pregabalin, an anticonvulsant on pain behavior of stroke patients with shoulder pain in a comparative study with ultrasound therapy and ultimately to recommend a better treatment option to improve pain and function in post stroke shoulder pain."7.80Comparative efficacy of pregabalin and therapeutic ultrasound versus therapeutic ultrasound alone on patients with post stroke shoulder pain. ( Rahman, MS; Uddin, MT, 2014)
"Pregabalin, a Ca(2+) channel α(2)δ-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke."7.77Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome. ( Greig, NH; Lee, JH; Mattson, MP; Mughal, MR; Son, TG; Yoon, JS, 2011)
"We present 2 patients with severe and intractable central poststroke pain (CPSP) after right posterolateral thalamic infarcts who were successfully treated with zonisamide."7.72Successful use of zonisamide for central poststroke pain. ( Hashimoto, K; Takahashi, Y; Tsuji, S, 2004)
"Although gabapentin was originally developed for treating partial seizures, it has been used mainly to treat various peripheral neuropathic pain conditions; however, there is very limited experience with gabapentin for the treatment of pain conditions of the central nervous system like central post-stroke pain syndrome."7.71Central post-stroke pain syndrome: yet another use for gabapentin? ( Chen, B; DeLisa, JA; Foye, PM; Nadler, SF; Stitik, TP, 2002)
"The effects of aniracetam, a cognition enhancer, on extracellular levels of glutamate (Glu), gamma-aminobutyric acid (GABA) and nitric oxide metabolites (NOx) were examined in the prefrontal cortex (PFC) and the basolateral amygdala (AMG) in stroke-prone spontaneously hypertensive rats (SHRSP) using in vivo microdialysis."7.71Aniracetam enhances glutamatergic transmission in the prefrontal cortex of stroke-prone spontaneously hypertensive rats. ( Matsumoto, M; Nakamura, K; Ohashi, S; Saito, H; Togashi, H; Ueno, K; Yoshioka, M, 2002)
" Adverse events were more frequent with pregabalin than with placebo and caused discontinuation in 9 (8."6.76Safety and efficacy of pregabalin in patients with central post-stroke pain. ( Bashford, G; Cheung, R; Dror, V; Kim, JS; Martin, A; Murphy, KT, 2011)
"Gabapentin monotherapy was useful and safe for late poststroke ES."6.70Gabapentin in late-onset poststroke seizures. ( Alvarez-Sabín, J; Codina, A; Molina, CA; Montaner, J; Padró, L; Quintana, M; Rovira, R, 2002)
"Stroke is a frequent cause of epileptic seizures (ES) in adults."6.70Gabapentin in late-onset poststroke seizures. ( Alvarez-Sabín, J; Codina, A; Molina, CA; Montaner, J; Padró, L; Quintana, M; Rovira, R, 2002)
"We measured 4 plasma amino acid neurotransmitters (glutamic acid, aspartic acid, gamma-aminobutyric acid, and glycine) among 3486 patients with ischemic stroke from 26 hospitals across China."5.69Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study. ( Chen, J; Guo, D; He, J; Jia, Y; Peng, H; Shi, M; Sun, L; Wang, A; Wang, Y; Xu, Q; Xu, T; Yang, P; Zhang, Y; Zhong, C; Zhu, Z, 2023)
"Increased glutamic acid, aspartic acid, and gamma-aminobutyric acid and decreased glycine in plasma are associated with adverse outcomes after ischemic stroke, suggesting that plasma amino acid neurotransmitters may be potential intervention targets for improving prognosis of ischemic stroke."5.69Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study. ( Chen, J; Guo, D; He, J; Jia, Y; Peng, H; Shi, M; Sun, L; Wang, A; Wang, Y; Xu, Q; Xu, T; Yang, P; Zhang, Y; Zhong, C; Zhu, Z, 2023)
"Central poststroke pain is a neuropathic pain syndrome that can occur from pathology of the brain."5.43A Medication Combination for the Treatment of Central Poststroke Pain via the Adjuvant Use of Prednisone With Gabapentin: A Case Report. ( Batlle, L; Irwin, R; Mattie, R, 2016)
"Treatment with gabapentin was initiated, with good results at 6-month follow-up."5.31Gabapentin treatment in a child with delayed-onset hemichorea/hemiballismus. ( Kothare, SV; Kulberg, AG; Pollack, P; Ravin, PD, 2000)
" Stroke Impairment Assessment Set (SIAS) was adopted to assess the whole function status after sroke, and the contents of glutamate (Glu) and gamma-aminobutyric acid (GABA) in serum and clinical efficacy were observed in the two groups."5.16[Comparative study on effects between electroacupuncture and acupuncture for spastic paralysis after stroke]. ( Chang, XR; Chen, LL; Jiang, JM; Li, L; Yue, ZH; Zhu, XS, 2012)
"Pregabalin has demonstrated efficacy in several forms of neuropathic pain, but its long-term efficacy in central post-stroke pain (CPSP) is unproven."5.15Safety and efficacy of pregabalin in patients with central post-stroke pain. ( Bashford, G; Cheung, R; Dror, V; Kim, JS; Martin, A; Murphy, KT, 2011)
"This review provides moderate-quality evidence that fails to support the use of GABA receptor agonists (chlormethiazole or diazepam) for the treatment of people with acute stroke."4.98Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. ( Liu, J; Wang, LN; Zhang, J, 2018)
" However, two randomised placebo-controlled studies have recently emerged demonstrating efficacy of pregabalin in reducing central neuropathic pain due to spinal cord injury and central poststroke pain."4.84Pregabalin in the management of central neuropathic pain. ( Gray, P, 2007)
"In patients with diabetic neuropathy who were prescribed gabapentin and pregabalin, there is an increased risk for heart failure, myocardial infarction, peripheral vascular disease, stroke, deep venous thrombosis, and pulmonary embolism with long-term use."4.12Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy. ( Blankfield, RP; Davis, PB; Kaebler, DC; Pan, Y; Xu, R, 2022)
"Gabapentin and pregabalin are commonly prescribed medications to treat pain in patients with diabetic neuropathy."4.12Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy. ( Blankfield, RP; Davis, PB; Kaebler, DC; Pan, Y; Xu, R, 2022)
"The study was designed to compare the efficacy of pregabalin, an anticonvulsant on pain behavior of stroke patients with shoulder pain in a comparative study with ultrasound therapy and ultimately to recommend a better treatment option to improve pain and function in post stroke shoulder pain."3.80Comparative efficacy of pregabalin and therapeutic ultrasound versus therapeutic ultrasound alone on patients with post stroke shoulder pain. ( Rahman, MS; Uddin, MT, 2014)
"We have reported that in rats with a 90 min left middle cerebral artery occlusion (MCAO) and 24 h reperfusion, pressor responses during muscle contractions were attenuated, as were glutamate concentrations in the left rostral ventrolateral medulla (RVLM) and left caudal VLM (CVLM), but gamma-aminobutyric acid (GABA) levels increased in left RVLM and CVLM."3.79Effects of medullary administration of a nitric oxide precursor on cardiovascular responses and neurotransmission during static exercise following ischemic stroke. ( Ally, A; Maher, TJ; Phattanarudee, S; Towiwat, P, 2013)
"Pregabalin, a Ca(2+) channel α(2)δ-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke."3.77Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome. ( Greig, NH; Lee, JH; Mattson, MP; Mughal, MR; Son, TG; Yoon, JS, 2011)
"We present 2 patients with severe and intractable central poststroke pain (CPSP) after right posterolateral thalamic infarcts who were successfully treated with zonisamide."3.72Successful use of zonisamide for central poststroke pain. ( Hashimoto, K; Takahashi, Y; Tsuji, S, 2004)
"Experimental studies have suggested that ischemic stroke causes increment in extracellular level of gamma-aminobutyric acid in response to excessive glutamate concentration and function."3.72GABA in ischemic stroke. Proton magnetic resonance study. ( Głodzik-Sobańska, L; Kozub, J; Sobiecka, B; Szczudlik, A; Słowik, A; Urbanik, A, 2004)
"Although gabapentin was originally developed for treating partial seizures, it has been used mainly to treat various peripheral neuropathic pain conditions; however, there is very limited experience with gabapentin for the treatment of pain conditions of the central nervous system like central post-stroke pain syndrome."3.71Central post-stroke pain syndrome: yet another use for gabapentin? ( Chen, B; DeLisa, JA; Foye, PM; Nadler, SF; Stitik, TP, 2002)
"The effects of aniracetam, a cognition enhancer, on extracellular levels of glutamate (Glu), gamma-aminobutyric acid (GABA) and nitric oxide metabolites (NOx) were examined in the prefrontal cortex (PFC) and the basolateral amygdala (AMG) in stroke-prone spontaneously hypertensive rats (SHRSP) using in vivo microdialysis."3.71Aniracetam enhances glutamatergic transmission in the prefrontal cortex of stroke-prone spontaneously hypertensive rats. ( Matsumoto, M; Nakamura, K; Ohashi, S; Saito, H; Togashi, H; Ueno, K; Yoshioka, M, 2002)
"Stroke is a major cause of death and chronic neurological disability."3.01An integrated measure of GABA to characterize post-stroke plasticity. ( Maquet, P; Paparella, I; Stagg, CJ; Vanderwalle, G, 2023)
" Number and type of adverse events were similar between the three groups."2.94Safety and efficacy of GABA ( Audoli-Inthavong, ML; Bassetti, CL; Chabriat, H; Hermann, DM; Lambert, E; Marx, U; Sors, A; Wattez, M, 2020)
" Adverse events were more frequent with pregabalin than with placebo and caused discontinuation in 9 (8."2.76Safety and efficacy of pregabalin in patients with central post-stroke pain. ( Bashford, G; Cheung, R; Dror, V; Kim, JS; Martin, A; Murphy, KT, 2011)
"Gabapentin monotherapy was useful and safe for late poststroke ES."2.70Gabapentin in late-onset poststroke seizures. ( Alvarez-Sabín, J; Codina, A; Molina, CA; Montaner, J; Padró, L; Quintana, M; Rovira, R, 2002)
"Stroke is a frequent cause of epileptic seizures (ES) in adults."2.70Gabapentin in late-onset poststroke seizures. ( Alvarez-Sabín, J; Codina, A; Molina, CA; Montaner, J; Padró, L; Quintana, M; Rovira, R, 2002)
"Stroke is a leading cause of long-term disability, with around three-quarters of stroke survivors experiencing motor problems."2.58Neurochemical changes underpinning the development of adjunct therapies in recovery after stroke: A role for GABA? ( Hinson, EL; Johnstone, A; Levenstein, JM; Stagg, CJ, 2018)
"Somnolence and rhinitis are frequent adverse events related to chlormethiazole."2.58Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. ( Liu, J; Wang, LN; Zhang, J, 2018)
"Central neuropathic pain is a painful condition, often severe, that occurs in a person who is already affected by an injury or disease of the brain or spinal cord."2.44Pregabalin in the management of central neuropathic pain. ( Gray, P, 2007)
"Chronic hiccup is not so rare in patients suffering from stroke: its impact on quality of life and on rehabilitation management is substantial, and it may be closely related to aspiration pneumonia, respiratory arrest and nutritional depletion."2.42Gabapentin as a drug therapy of intractable hiccup because of vascular lesion: a three-year follow up. ( Antonello, RM; Bava, A; Cazzato, G; Moretti, R; Torre, P; Ukmar, M, 2004)
"Because of this cause we decided to treat intractable hiccups in patients with ischemic lesions of the medulla with a short course of gabapentin."2.42Gabapentin as a drug therapy of intractable hiccup because of vascular lesion: a three-year follow up. ( Antonello, RM; Bava, A; Cazzato, G; Moretti, R; Torre, P; Ukmar, M, 2004)
"TTC staining was used to detect cerebral infarction volume, and the brain water content of rats in each group was determined by wet and dry weight method."1.91[Effects of Governor Vessel electroacupuncture on chloridion homeostasis in the cortex of rats with limb spasm after cerebral ischemia-reperfusion]. ( Guo, J; Li, JW; Li, RQ; Mei, JJ; Wang, YY; Zhang, JY; Zhang, LH, 2023)
" However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown."1.72Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy. ( Blankfield, RP; Davis, PB; Kaebler, DC; Pan, Y; Xu, R, 2022)
"Waggle needling, a classical anti-spastic needling technique characterized by combination of acupuncture with joint movement, has gained increasing popularity of spasticity treatment in China."1.56Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid. ( Gan, YY; Guo, MW; Li, JL; Ma, LX; Mu, JD; Qian, X; Ren, XX; Song, Y; Sun, TY; Tian, Y; Wang, JX; Yu, WY, 2020)
"Stroke is a leading cause of adult disability owing largely to motor impairment and loss of function."1.51The Influence of Primary Motor Cortex Inhibition on Upper Limb Impairment and Function in Chronic Stroke: A Multimodal Study. ( Ackerley, SJ; Barber, PA; Byblow, WD; Cirillo, J; Mooney, RA; Rajeswaran, DK; Stinear, CM, 2019)
"Central poststroke pain is a neuropathic pain syndrome that can occur from pathology of the brain."1.43A Medication Combination for the Treatment of Central Poststroke Pain via the Adjuvant Use of Prednisone With Gabapentin: A Case Report. ( Batlle, L; Irwin, R; Mattie, R, 2016)
" We performed unilateral ventralis caudalis deep brain stimulation combined with stereotactic bilateral cingulotomy to maximize the effects of treatment for 3 patients with intractable post-stroke pain."1.38Impact of ventralis caudalis deep brain stimulation combined with stereotactic bilateral cingulotomy for treatment of post-stroke pain. ( Chang, JW; Chang, WS; Kim, JP; Park, YS, 2012)
"Conversely, in painted turtle brain anoxia increases γ-amino butyric acid (GABA)ergic suppression of spontaneous electrical activity, and cell death is prevented."1.38Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. ( Buck, LT; Gu, XQ; Haddad, GG; Hogg, DW; Pamenter, ME, 2012)
"Stroke is the third leading cause of death worldwide."1.38Impact of ventralis caudalis deep brain stimulation combined with stereotactic bilateral cingulotomy for treatment of post-stroke pain. ( Chang, JW; Chang, WS; Kim, JP; Park, YS, 2012)
"Stroke is a leading cause of disability, but no pharmacological therapy is currently available for promoting recovery."1.36Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. ( Carmichael, ST; Clarkson, AN; Huang, BS; Macisaac, SE; Mody, I, 2010)
"Malignant cerebral infarction (MaCI) treated with mechanical ventilation, mannitol, or barbiturates has a mortality of about 80% and survivors show severe disability."1.33Prolonged moderate hypothermia in massive hemispheric infarction: clinical experience. ( Escuret, E; Heroum, C; Milhaud, D; Thouvenot, E, 2005)
"We introduced intracerebral hemorrhage in each of eight anesthetized New Zealand rabbits by injecting 0."1.32Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study. ( Ali, Z; Baker, G; Guterman, LR; Hopkins, LN; Qureshi, AI; Shuaib, A; Suri, MF; Todd, K, 2003)
"Treatment with gabapentin was initiated, with good results at 6-month follow-up."1.31Gabapentin treatment in a child with delayed-onset hemichorea/hemiballismus. ( Kothare, SV; Kulberg, AG; Pollack, P; Ravin, PD, 2000)

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's27 (32.93)29.6817
2010's38 (46.34)24.3611
2020's17 (20.73)2.80

Authors

AuthorsStudies
Chen, QM1
Yao, FR1
Sun, HW1
Chen, ZG1
Ke, J1
Liao, J1
Cai, XY1
Yu, LQ1
Wu, ZY1
Wang, Z1
Pan, X1
Liu, HY1
Li, L2
Zhang, QQ1
Ling, WH1
Fang, Q1
Kim, J1
Guo, L1
Hishinuma, A1
Lemke, S1
Ramanathan, DS1
Won, SJ1
Ganguly, K1
Mu, JD3
Ma, LX3
Zhang, Z2
Yu, WY3
Sun, TY3
Qian, X3
Tian, Y3
Wang, JX3
Zhang, YD1
Li, JW2
Hu, YC1
Wang, YY2
Mei, JJ2
Gao, J1
Ren, BB1
Feng, XD1
Li, RQ2
Pan, Y1
Davis, PB1
Kaebler, DC1
Blankfield, RP1
Xu, R1
Liu, W2
He, X2
Lin, H2
Yang, M2
Dai, Y2
Chen, L4
Li, C2
Liang, S2
Tao, J2
Paparella, I1
Vanderwalle, G1
Stagg, CJ4
Maquet, P1
Willis, HE1
Ip, IB1
Watt, A1
Campbell, J1
Jbabdi, S1
Clarke, WT1
Cavanaugh, MR1
Huxlin, KR1
Watkins, KE1
Tamietto, M1
Bridge, H1
Zhang, LH1
Zhang, JY1
Guo, J1
Zhu, Z1
Yang, P1
Jia, Y1
Wang, Y2
Shi, M1
Zhong, C1
Peng, H1
Sun, L1
Guo, D1
Xu, Q2
Chen, J3
Wang, A1
Xu, T1
He, J1
Zhang, Y2
Chabriat, H1
Bassetti, CL1
Marx, U1
Audoli-Inthavong, ML1
Sors, A1
Lambert, E1
Wattez, M1
Hermann, DM1
Song, Y1
Gan, YY1
Guo, MW1
Ren, XX1
Li, JL1
Wan, L1
Li, Z2
Liu, T1
Chen, X1
Yao, W1
Zhang, C1
Esin, RG2
Esin, OR2
Khakimova, AR1
Nam, MH1
Cho, J1
Kwon, DH1
Park, JY1
Woo, J1
Lee, JM1
Lee, S1
Ko, HY1
Won, W1
Kim, RG1
Song, H1
Oh, SJ1
Choi, JW1
Park, KD1
Park, EK1
Jung, H1
Kim, HS1
Lee, MC1
Yun, M1
Lee, CJ1
Kim, HI1
Lin, Y1
Yao, M1
Wu, H1
Wu, F1
Cao, S1
Ni, H1
Dong, J1
Yang, D1
Sun, Y1
Kou, X1
Li, J1
Xiao, H1
Chang, L1
Wu, J1
Liu, Y1
Luo, C1
Zhu, D1
Daglia, M2
Di Lorenzo, A2
Nabavi, SF2
Sureda, A2
Khanjani, S2
Moghaddam, AH2
Braidy, N1
Nabavi, SM2
Johnstone, A1
Levenstein, JM1
Hinson, EL1
Roy, M1
Sorokina, O1
Skene, N1
Simonnet, C1
Mazzo, F1
Zwart, R1
Sher, E1
Smith, C1
Armstrong, JD1
Grant, SGN1
Orfila, JE1
Grewal, H1
Dietz, RM1
Strnad, F1
Shimizu, T1
Moreno, M1
Schroeder, C1
Yonchek, J1
Rodgers, KM1
Dingman, A1
Bernard, TJ1
Quillinan, N1
Macklin, WB1
Traystman, RJ1
Herson, PS1
Andrushko, JW1
Zirk, DT1
Liu, J1
Zhang, J1
Wang, LN1
Mooney, RA1
Ackerley, SJ1
Rajeswaran, DK1
Cirillo, J1
Barber, PA1
Stinear, CM1
Byblow, WD1
O'Shea, J1
Boudrias, MH1
Bachtiar, V2
Kischka, U1
Blicher, JU2
Johansen-Berg, H1
Phattanarudee, S1
Towiwat, P1
Maher, TJ1
Ally, A1
Málly, J1
Rahman, MS1
Uddin, MT1
Yang, F4
Fu, H2
Lu, YF2
Wang, XL1
Yang, Y2
Yu, YQ2
Sun, W2
Wang, JS1
Costigan, M1
Liu, C1
Li, R1
Song, X1
Feng, X1
Shao, B1
Zhou, YL1
Wang, H1
Lin, YS1
Kurzepa, J1
Szpetnar, M1
Hordyjewska, A1
Wątroba, S1
Gołąb, P1
Boguszewska-Czubara, A1
Duan, CL1
Liu, CW1
Shen, SW1
Yu, Z1
Mo, JL1
Chen, XH1
Sun, FY1
Fleming, GF1
Sitnova, MA1
Modi, JP1
Prentice, H1
Wu, JY1
Batlle, L1
Mattie, R1
Irwin, R1
Mäkelä, JP1
Lioumis, P1
Laaksonen, K1
Forss, N1
Tatlisumak, T1
Kaste, M1
Mustanoja, S1
Arcidiaco, P1
Li, CL1
He, T1
Wang, RR1
Pennisi, E1
Jakobsen, J1
Andersen, G1
Nielsen, JF1
Carlsson, KC1
Savić, RM1
Hooker, AC1
Karlsson, MO1
Hummel, FC1
Steven, B1
Hoppe, J1
Heise, K1
Thomalla, G1
Cohen, LG1
Gerloff, C1
Gu, W1
Gu, C1
Jiang, W1
Wester, P1
Fishell, G1
Goldman, JE1
Clarkson, AN1
Huang, BS1
Macisaac, SE1
Mody, I1
Carmichael, ST2
Staley, K1
Yoon, JS1
Lee, JH1
Son, TG1
Mughal, MR1
Greig, NH1
Mattson, MP1
Kim, JS1
Bashford, G1
Murphy, KT1
Martin, A1
Dror, V1
Cheung, R1
Attal, N1
Chen, WH1
Yin, HL1
Kim, JP1
Chang, WS1
Park, YS1
Chang, JW1
Pamenter, ME1
Hogg, DW1
Gu, XQ1
Buck, LT1
Haddad, GG1
Yue, ZH1
Chang, XR1
Jiang, JM1
Chen, LL1
Zhu, XS1
Molinaro, P1
Cantile, M1
Cuomo, O1
Secondo, A1
Pannaccione, A1
Ambrosino, P1
Pignataro, G1
Fiorino, F1
Severino, B1
Gatta, E1
Sisalli, MJ1
Milanese, M1
Scorziello, A1
Bonanno, G1
Robello, M1
Santagada, V1
Caliendo, G1
Di Renzo, G1
Annunziato, L1
Chen, B1
Stitik, TP1
Foye, PM1
Nadler, SF1
DeLisa, JA1
Yager, JY1
Hartfield, DS1
Alvarez-Sabín, J1
Montaner, J1
Padró, L1
Molina, CA1
Rovira, R1
Codina, A1
Quintana, M1
Cincotta, M1
Borgheresi, A1
Balestrieri, F1
Zaccara, G1
Yen, HL1
Chan, W1
Qureshi, AI1
Ali, Z1
Suri, MF1
Shuaib, A1
Baker, G1
Todd, K1
Guterman, LR1
Hopkins, LN1
Matsko, MA1
Ivanova, NE1
Hársing, LG1
Gigler, G1
Albert, M1
Szénási, G1
Simó, A1
Móricz, K1
Varga, A1
Ling, I1
Bagdy, E1
Király, I1
Sólyom, S1
Jurányi, Z1
Moretti, R1
Torre, P1
Antonello, RM1
Ukmar, M1
Cazzato, G1
Bava, A1
Takahashi, Y1
Hashimoto, K1
Tsuji, S1
Zádor, Z1
Benyó, Z1
Lacza, Z1
Hortobágyi, T2
Harkány, T1
Rotella, DP1
Milhaud, D1
Thouvenot, E1
Heroum, C1
Escuret, E1
Madden, K1
Clark, W1
Lessov, N1
Serena, J1
Blanco, M1
Castellanos, M1
Silva, Y1
Vivancos, J1
Moro, MA1
Leira, R1
Lizasoain, I1
Castillo, J1
Dávalos, A1
Głodzik-Sobańska, L1
Słowik, A1
Kozub, J1
Sobiecka, B1
Urbanik, A1
Szczudlik, A1
Choudhuri, I1
Sarvananthan, N1
Gottlob, I1
Lalonde, RL1
Kowalski, KG1
Hutmacher, MM1
Ewy, W1
Nichols, DJ1
Milligan, PA1
Corrigan, BW1
Lockwood, PA1
Marshall, SA1
Benincosa, LJ1
Tensfeldt, TG1
Parivar, K1
Amantea, M1
Glue, P1
Koide, H1
Miller, R1
Gray, P1
Kothare, SV1
Pollack, P1
Kulberg, AG1
Ravin, PD1
Goldstein, LB1
Fisher, M1
Schaebitz, W1
Nelson, RM1
Hainsworth, AH1
Lambert, DG1
Jones, JA1
Murray, TK1
Richards, DA1
Gabrielsson, J1
Cross, AJ1
Green, AR1
Togashi, H1
Nakamura, K1
Matsumoto, M1
Ueno, K1
Ohashi, S1
Saito, H1
Yoshioka, M1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Efficacy and Safety Trial With Oral S 44819 After Recent Ischemic Cerebral Event. International, Multi-centre, Randomized, Doubleblind Placebo-controlled Phase II Study. (RESTORE BRAIN Study)[NCT02877615]Phase 2585 participants (Actual)Interventional2016-12-19Completed
An Open Label, Non-Randomized Multisite Phase II Trial Combining Bevacizumab, Atezolizumab and Rucaparib for the Treatment of Previously Treated Recurrent and Progressive Endometrial Carcinoma[NCT03694262]Phase 230 participants (Actual)Interventional2019-07-19Completed
Transcranial Direct Current Stimulation on Inhibitory Control in Addictions: a Triple-blinded, Sham-controlled Clinical Trial.[NCT05350033]200 participants (Anticipated)Interventional2021-04-05Enrolling by invitation
The Øresund Copenhagen-Malmø Acute Stroke Cooling Trial[NCT01500421]Phase 231 participants (Actual)Interventional2008-10-31Completed
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]8 participants (Actual)Interventional2009-11-30Terminated (stopped due to PI left institution)
Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.[NCT02462317]Phase 4184 participants (Actual)Interventional2015-04-30Completed
Cortex Motor Function Reorganization in Stroke Patients: A Longitudinal fMRI Study[NCT04794673]36 participants (Actual)Observational2020-01-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

15 reviews available for gamma-aminobutyric acid and Stroke

ArticleYear
An integrated measure of GABA to characterize post-stroke plasticity.
    NeuroImage. Clinical, 2023, Volume: 39

    Topics: gamma-Aminobutyric Acid; Humans; Stroke

2023
Epoxyeicosatrienoic acids: Emerging therapeutic agents for central post-stroke pain.
    Pharmacological research, 2020, Volume: 159

    Topics: Analgesics; Animals; Brain; Chronic Pain; Eicosanoids; gamma-Aminobutyric Acid; Humans; Inflammation

2020
Neurochemical changes underpinning the development of adjunct therapies in recovery after stroke: A role for GABA?
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018, Volume: 38, Issue:9

    Topics: Animals; Combined Modality Therapy; Electric Stimulation Therapy; gamma-Aminobutyric Acid; Humans; N

2018
Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.
    The Cochrane database of systematic reviews, 2018, 10-30, Volume: 10

    Topics: Acute Disease; Chlormethiazole; Diazepam; Disorders of Excessive Somnolence; GABA Agonists; gamma-Am

2018
Non-invasive brain stimulation (rTMS and tDCS) in patients with aphasia: mode of action at the cellular level.
    Brain research bulletin, 2013, Volume: 98

    Topics: Aphasia; Biophysics; Brain; Electric Stimulation Therapy; gamma-Aminobutyric Acid; Glutamic Acid; Hu

2013
The role of inhibition in human motor cortical plasticity.
    Neuroscience, 2014, Oct-10, Volume: 278

    Topics: Brain; gamma-Aminobutyric Acid; Humans; Learning; Motor Activity; Motor Cortex; Neural Inhibition; N

2014
Second-Line Therapy for Endometrial Cancer: The Need for Better Options.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adenocarcinoma; Amines; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Clinical Trials

2015
Brain excitability in stroke: the yin and yang of stroke progression.
    Archives of neurology, 2012, Volume: 69, Issue:2

    Topics: Brain; Cerebral Infarction; Disease Progression; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lea

2012
Neurologic manifestations of iron deficiency in childhood.
    Pediatric neurology, 2002, Volume: 27, Issue:2

    Topics: Anemia, Iron-Deficiency; Brain Diseases; Child; Child, Preschool; Developmental Disabilities; Dopami

2002
Gabapentin as a drug therapy of intractable hiccup because of vascular lesion: a three-year follow up.
    The neurologist, 2004, Volume: 10, Issue:2

    Topics: Acetates; Aged; Amines; Brain Stem; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists;

2004
[Neuroprotection in brain ischemia--doubts and hopes].
    Ideggyogyaszati szemle, 2004, Mar-20, Volume: 57, Issue:3-4

    Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channels; Cerebrovascular Circulation; Clinical Trials a

2004
Model-based drug development.
    Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:1

    Topics: Alzheimer Disease; Amines; Analgesics; Animals; Anticholesteremic Agents; Bridged Bicyclo Compounds,

2007
Pregabalin in the management of central neuropathic pain.
    Expert opinion on pharmacotherapy, 2007, Volume: 8, Issue:17

    Topics: Analgesics; Animals; gamma-Aminobutyric Acid; Humans; Multiple Sclerosis; Neuralgia; Pregabalin; Ris

2007
Effects of amphetamines and small related molecules on recovery after stroke in animals and man.
    Neuropharmacology, 2000, Mar-03, Volume: 39, Issue:5

    Topics: Amphetamines; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antihypertensive

2000
Effects of amphetamines and small related molecules on recovery after stroke in animals and man.
    Neuropharmacology, 2000, Mar-03, Volume: 39, Issue:5

    Topics: Amphetamines; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antihypertensive

2000
Effects of amphetamines and small related molecules on recovery after stroke in animals and man.
    Neuropharmacology, 2000, Mar-03, Volume: 39, Issue:5

    Topics: Amphetamines; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antihypertensive

2000
Effects of amphetamines and small related molecules on recovery after stroke in animals and man.
    Neuropharmacology, 2000, Mar-03, Volume: 39, Issue:5

    Topics: Amphetamines; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antihypertensive

2000
An overview of acute stroke therapy: past, present, and future.
    Archives of internal medicine, 2000, Nov-27, Volume: 160, Issue:21

    Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia;

2000

Trials

7 trials available for gamma-aminobutyric acid and Stroke

ArticleYear
Combining inhibitory and facilitatory repetitive transcranial magnetic stimulation (rTMS) treatment improves motor function by modulating GABA in acute ischemic stroke patients.
    Restorative neurology and neuroscience, 2021, Volume: 39, Issue:6

    Topics: gamma-Aminobutyric Acid; Humans; Ischemic Stroke; Recovery of Function; Stroke; Stroke Rehabilitatio

2021
Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study.
    The American journal of clinical nutrition, 2023, Volume: 118, Issue:4

    Topics: Aspartic Acid; Biomarkers; Brain Ischemia; Cohort Studies; gamma-Aminobutyric Acid; Glutamic Acid; G

2023
Safety and efficacy of GABA
    The Lancet. Neurology, 2020, Volume: 19, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Benzodiazepines; Brain; Brain Ischemia; Double-Blind Method; Female;

2020
Safety and efficacy of pregabalin in patients with central post-stroke pain.
    Pain, 2011, Volume: 152, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; F

2011
[Comparative study on effects between electroacupuncture and acupuncture for spastic paralysis after stroke].
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2012, Volume: 32, Issue:7

    Topics: Acupuncture Therapy; Electroacupuncture; gamma-Aminobutyric Acid; Glutamic Acid; Muscle Spasticity;

2012
Gabapentin in late-onset poststroke seizures.
    Neurology, 2002, Dec-24, Volume: 59, Issue:12

    Topics: Acetates; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Dr

2002
The prediction of malignant cerebral infarction by molecular brain barrier disruption markers.
    Stroke, 2005, Volume: 36, Issue:9

    Topics: Aged; Biomarkers; Blood-Brain Barrier; Brain; Case-Control Studies; Edema; Female; Fibronectins; gam

2005

Other Studies

60 other studies available for gamma-aminobutyric acid and Stroke

ArticleYear
Recovery of consolidation after sleep following stroke-interaction of slow waves, spindles, and GABA.
    Cell reports, 2022, 03-01, Volume: 38, Issue:9

    Topics: Animals; Electroencephalography; gamma-Aminobutyric Acid; Memory Consolidation; Rats; Sleep; Stroke

2022
Acupuncture alleviates spinal hyperreflexia and motor dysfunction in post-ischemic stroke rats with spastic hypertonia via KCC2-mediated spinal GABA
    Experimental neurology, 2022, Volume: 354

    Topics: Acupuncture Therapy; Animals; gamma-Aminobutyric Acid; Humans; Ischemic Stroke; Muscle Hypertonia; M

2022
Acupuncture improves the structure of spastic muscle and decreases spasticity by enhancing GABA, KCC2, and GABAAγ2 in the brainstem in rats after ischemic stroke.
    Neuroreport, 2022, 06-08, Volume: 33, Issue:9

    Topics: Acupuncture Therapy; Animals; Brain Stem; gamma-Aminobutyric Acid; Infarction, Middle Cerebral Arter

2022
[Effect of electroacupuncture of Governor Vessel on expression of GAD67 and GABA-T in cerebral cortex of rats with post-stroke limb spasticity].
    Zhen ci yan jiu = Acupuncture research, 2022, Aug-25, Volume: 47, Issue:8

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Electroacupuncture; gamma-Aminobutyric Acid; Glutamate Dec

2022
Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy.
    Cardiovascular diabetology, 2022, 09-01, Volume: 21, Issue:1

    Topics: Amines; Analgesics; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Gab

2022
Ischemic stroke rehabilitation through optogenetic modulation of parvalbumin neurons in the contralateral motor cortex.
    Experimental neurology, 2023, Volume: 360

    Topics: Animals; gamma-Aminobutyric Acid; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Motor

2023
Ischemic stroke rehabilitation through optogenetic modulation of parvalbumin neurons in the contralateral motor cortex.
    Experimental neurology, 2023, Volume: 360

    Topics: Animals; gamma-Aminobutyric Acid; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Motor

2023
Ischemic stroke rehabilitation through optogenetic modulation of parvalbumin neurons in the contralateral motor cortex.
    Experimental neurology, 2023, Volume: 360

    Topics: Animals; gamma-Aminobutyric Acid; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Motor

2023
Ischemic stroke rehabilitation through optogenetic modulation of parvalbumin neurons in the contralateral motor cortex.
    Experimental neurology, 2023, Volume: 360

    Topics: Animals; gamma-Aminobutyric Acid; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Motor

2023
GABA and Glutamate in hMT+ Link to Individual Differences in Residual Visual Function After Occipital Stroke.
    Stroke, 2023, Volume: 54, Issue:9

    Topics: gamma-Aminobutyric Acid; Glutamic Acid; Humans; Individuality; Magnetic Resonance Imaging; Photic St

2023
[Effects of Governor Vessel electroacupuncture on chloridion homeostasis in the cortex of rats with limb spasm after cerebral ischemia-reperfusion].
    Zhen ci yan jiu = Acupuncture research, 2023, Sep-25, Volume: 48, Issue:9

    Topics: Animals; Baclofen; Cerebral Cortex; Cerebral Infarction; Electroacupuncture; gamma-Aminobutyric Acid

2023
Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid.
    Neuroreport, 2020, 07-10, Volume: 31, Issue:10

    Topics: 4-Aminobutyrate Transaminase; Acupuncture Therapy; Animals; Brain Ischemia; gamma-Aminobutyric Acid;

2020
[Stress-induced disorders].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2020, Volume: 120, Issue:5

    Topics: Dizziness; gamma-Aminobutyric Acid; Humans; Stress, Physiological; Stroke

2020
Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke.
    Cell reports, 2020, 07-07, Volume: 32, Issue:1

    Topics: Animals; Astrocytes; Cerebral Cortex; gamma-Aminobutyric Acid; Glucose; Male; Models, Biological; Mo

2020
Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery.
    Theranostics, 2021, Volume: 11, Issue:8

    Topics: Animals; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric

2021
Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression.
    Nutrients, 2017, Apr-29, Volume: 9, Issue:5

    Topics: Affect; Animals; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamates; Glutamic A

2017
Proteomic analysis of postsynaptic proteins in regions of the human neocortex.
    Nature neuroscience, 2018, Volume: 21, Issue:1

    Topics: Animals; Computational Biology; Female; gamma-Aminobutyric Acid; Humans; Image Processing, Computer-

2018
Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019, Volume: 39, Issue:6

    Topics: Animals; Brain Ischemia; Cognition; gamma-Aminobutyric Acid; Hippocampus; Long-Term Potentiation; Ma

2019
Functional relevance of stroke-related losses in GABA
    The Journal of physiology, 2018, Volume: 596, Issue:16

    Topics: gamma-Aminobutyric Acid; Humans; Recovery of Function; Stroke

2018
The Influence of Primary Motor Cortex Inhibition on Upper Limb Impairment and Function in Chronic Stroke: A Multimodal Study.
    Neurorehabilitation and neural repair, 2019, Volume: 33, Issue:2

    Topics: Aged; Aged, 80 and over; Chronic Disease; Electromyography; Evoked Potentials, Motor; Female; gamma-

2019
Predicting behavioural response to TDCS in chronic motor stroke.
    NeuroImage, 2014, Jan-15, Volume: 85 Pt 3

    Topics: Adult; Aged; Aged, 80 and over; Electric Stimulation Therapy; Evoked Potentials, Motor; Female; gamm

2014
Effects of medullary administration of a nitric oxide precursor on cardiovascular responses and neurotransmission during static exercise following ischemic stroke.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:7

    Topics: Animals; Arginine; Cardiovascular System; Female; gamma-Aminobutyric Acid; Glutamic Acid; Infarction

2013
Comparative efficacy of pregabalin and therapeutic ultrasound versus therapeutic ultrasound alone on patients with post stroke shoulder pain.
    Mymensingh medical journal : MMJ, 2014, Volume: 23, Issue:3

    Topics: Adult; Aged; Analgesics; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pregabalin; Sho

2014
Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin.
    Neuroscience bulletin, 2014, Volume: 30, Issue:6

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-

2014
Effect of catgut implantation at acupoints on GABA(B) and mGluR1 expressions in brain stem of rats with spasticity after stroke. .
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2014, Volume: 34, Issue:5

    Topics: Acupuncture Points; Acupuncture Therapy; Animals; Brain Stem; Catgut; Disease Models, Animal; gamma-

2014
The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats.
    Physiology & behavior, 2015, Volume: 139

    Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Calcitonin Gene-Related Peptide; Chronic

2015
Thrombolytic treatment decreases glutamate/GABA ratio in serum during acute ischaemic stroke: a pilot study.
    Neurological research, 2015, Volume: 37, Issue:10

    Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; gamma-Aminobutyric Acid; Gluta

2015
Striatal astrocytes transdifferentiate into functional mature neurons following ischemic brain injury.
    Glia, 2015, Volume: 63, Issue:9

    Topics: Animals; Astrocytes; Brain Ischemia; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, A

2015
[The principles of pharmacotherapy of poststroke shoulder pain].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:5

    Topics: Amines; Amitriptyline; Anti-Inflammatory Agents; Clonidine; Cyclohexanecarboxylic Acids; Drug Therap

2015
Regulation of GABA Neurotransmission by Glutamic Acid Decarboxylase (GAD).
    Current pharmaceutical design, 2015, Volume: 21, Issue:34

    Topics: Animals; Calpain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Phosphorylation; Protein

2015
A Medication Combination for the Treatment of Central Poststroke Pain via the Adjuvant Use of Prednisone With Gabapentin: A Case Report.
    PM & R : the journal of injury, function, and rehabilitation, 2016, Volume: 8, Issue:3

    Topics: Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Thera

2016
Cortical Excitability Measured with nTMS and MEG during Stroke Recovery.
    Neural plasticity, 2015, Volume: 2015

    Topics: Aged; Aged, 80 and over; Beta Rhythm; Cerebral Cortex; Cortical Synchronization; Evoked Potentials,

2015
Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression.
    Molecular nutrition & food research, 2016, Volume: 60, Issue:3

    Topics: Animals; Antidepressive Agents; Antioxidants; Brain; Camellia sinensis; Depression; Disease Models,

2016
Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.
    Neuroscience bulletin, 2016, Volume: 32, Issue:1

    Topics: Amines; Analgesics; Animals; Blotting, Western; Calcium Channels; Cyclohexanecarboxylic Acids; Disea

2016
PHYSIOLOGY. A fish back from the dead.
    Science (New York, N.Y.), 2016, Jan-29, Volume: 351, Issue:6272

    Topics: Anaerobiosis; Animals; Fundulidae; gamma-Aminobutyric Acid; Humans; Hypoxia; MicroRNAs; Oxygen; Stro

2016
Cortical excitability in chronic stroke and modulation by training: a TMS study.
    Neurorehabilitation and neural repair, 2009, Volume: 23, Issue:5

    Topics: Adult; Aged; Brain Mapping; Cerebral Cortex; Chronic Disease; Electromyography; Evoked Potentials, M

2009
Modeling subpopulations with the $MIXTURE subroutine in NONMEM: finding the individual probability of belonging to a subpopulation for the use in model analysis and improved decision making.
    The AAPS journal, 2009, Volume: 11, Issue:1

    Topics: Algorithms; Anticonvulsants; Chlormethiazole; Computer Simulation; Decision Making; Decision Support

2009
Deficient intracortical inhibition (SICI) during movement preparation after chronic stroke.
    Neurology, 2009, May-19, Volume: 72, Issue:20

    Topics: Aged; Electromyography; Female; gamma-Aminobutyric Acid; Hand; Humans; Middle Aged; Motor Cortex; Mo

2009
Neurotransmitter synthesis in poststroke cortical neurogenesis in adult rats.
    Stem cell research, 2010, Volume: 4, Issue:2

    Topics: Acetylcholine; Animals; Animals, Newborn; Bromodeoxyuridine; Cerebral Cortex; Choline O-Acetyltransf

2010
A silver lining to stroke: does ischemia generate new cortical interneurons?
    Nature neuroscience, 2010, Volume: 13, Issue:2

    Topics: Adult Stem Cells; Animals; Brain Ischemia; Cell Cycle; Cell Movement; Cell Proliferation; Cerebral C

2010
Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke.
    Nature, 2010, Nov-11, Volume: 468, Issue:7321

    Topics: Animals; Benzodiazepines; Cerebral Infarction; Disease Models, Animal; Drug Inverse Agonism; GABA An

2010
Stroke: recovery inhibitors under attack.
    Nature, 2010, Nov-11, Volume: 468, Issue:7321

    Topics: Animals; Cerebral Infarction; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Mice

2010
Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome.
    Neurobiology of disease, 2011, Volume: 41, Issue:3

    Topics: Animals; Calcium; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbre

2011
Is pregabalin ineffective in poststroke pain?
    Pain, 2011, Volume: 152, Issue:5

    Topics: Analgesics; gamma-Aminobutyric Acid; Humans; Pain; Pregabalin; Stroke

2011
Successful amelioration of tinnitus in a stroke patient by low-dose gabapentin.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2012, Volume: 21, Issue:8

    Topics: Amines; Audiometry, Pure-Tone; Basal Ganglia Hemorrhage; Cerebral Angiography; Cyclohexanecarboxylic

2012
Impact of ventralis caudalis deep brain stimulation combined with stereotactic bilateral cingulotomy for treatment of post-stroke pain.
    Stereotactic and functional neurosurgery, 2012, Volume: 90, Issue:1

    Topics: Amines; Analgesics; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Deep Brain Stimulation;

2012
Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012, Volume: 32, Issue:11

    Topics: Action Potentials; Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Cerebrovascular Circulat

2012
Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.
    Molecular pharmacology, 2013, Volume: 83, Issue:1

    Topics: Animals; Benzodiazepinones; Calcium; Cell Death; Cells, Cultured; Cricetinae; Dogs; Flumazenil; GABA

2013
Central post-stroke pain syndrome: yet another use for gabapentin?
    American journal of physical medicine & rehabilitation, 2002, Volume: 81, Issue:9

    Topics: Acetates; Activities of Daily Living; Administration, Oral; Amines; Analgesics; Cyclohexanecarboxyli

2002
Reduced inhibition within primary motor cortex in patients with poststroke focal motor seizures.
    Neurology, 2003, Feb-11, Volume: 60, Issue:3

    Topics: Electric Stimulation; Electromagnetic Fields; gamma-Aminobutyric Acid; Humans; Interneurons; Motor C

2003
An East-West approach to the management of central post-stroke pain.
    Cerebrovascular diseases (Basel, Switzerland), 2003, Volume: 16, Issue:1

    Topics: Acetates; Acupuncture; Aged; Amines; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Secon

2003
Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study.
    Critical care medicine, 2003, Volume: 31, Issue:5

    Topics: Analysis of Variance; Animals; Asparagine; Aspartic Acid; Brain Ischemia; Cerebral Hemorrhage; Chrom

2003
[Changes in adaptation-compensatory processes in the course of acute ischemic stroke (clinico-biochemical comparisons)].
    Terapevticheskii arkhiv, 2003, Volume: 75, Issue:8

    Topics: Acid Phosphatase; Acute Disease; Adaptation, Physiological; Excitatory Amino Acids; Female; gamma-Am

2003
Neurotransmitter release in experimental stroke models: the role of glutamate-GABA interaction.
    Advances in experimental medicine and biology, 2004, Volume: 541

    Topics: Action Potentials; Animals; Brain; D-Aspartic Acid; Disease Models, Animal; Excitatory Amino Acid An

2004
Successful use of zonisamide for central poststroke pain.
    The journal of pain, 2004, Volume: 5, Issue:3

    Topics: Anticonvulsants; Calcium Channel Blockers; Calcium Channels, T-Type; Cerebral Infarction; Diabetes C

2004
American Chemical Society--227th annual meeting. Neuroprotection. 28 March - 1 April 2004, Anaheim, CA, USA.
    IDrugs : the investigational drugs journal, 2004, Volume: 7, Issue:5

    Topics: Animals; Antiparkinson Agents; Carbazoles; gamma-Aminobutyric Acid; Humans; Indoles; Neuroprotective

2004
Prolonged moderate hypothermia in massive hemispheric infarction: clinical experience.
    Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:1

    Topics: Adult; Cerebral Infarction; Female; gamma-Aminobutyric Acid; Humans; Hypotension; Hypothermia, Induc

2005
Failure of ischemic neuroprotection by potentiators of gamma-aminobutyric acid.
    Clinical medicine & research, 2003, Volume: 1, Issue:2

    Topics: Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Fructose; gamma-Aminobutyric Acid;

2003
GABA in ischemic stroke. Proton magnetic resonance study.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10 Suppl 3

    Topics: Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Female; gamma-Aminobutyric Acid; Huma

2004
Survey of management of acquired nystagmus in the United Kingdom.
    Eye (London, England), 2007, Volume: 21, Issue:9

    Topics: Amines; Baclofen; Cyclohexanecarboxylic Acids; Drug Utilization; Excitatory Amino Acid Antagonists;

2007
Gabapentin treatment in a child with delayed-onset hemichorea/hemiballismus.
    Pediatric neurology, 2000, Volume: 22, Issue:1

    Topics: Acetates; Adolescent; Age of Onset; Amines; Antiparkinson Agents; Basal Ganglia; Chorea; Cyclohexane

2000
Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.
    Neuropharmacology, 2001, Volume: 41, Issue:2

    Topics: Animals; Brain Ischemia; Chlormethiazole; Female; gamma-Aminobutyric Acid; Gerbillinae; Glutamic Aci

2001
Aniracetam enhances glutamatergic transmission in the prefrontal cortex of stroke-prone spontaneously hypertensive rats.
    Neuroscience letters, 2002, Mar-08, Volume: 320, Issue:3

    Topics: Amino Acids; Amygdala; Animals; Cerebral Infarction; Extracellular Space; gamma-Aminobutyric Acid; G

2002