gamma-aminobutyric acid has been researched along with Sensitivity and Specificity in 176 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred fifty-eight patients with moderate-to-severe postherpetic neuralgia were randomly assigned to 1 of 3 treatment conditions: (1) extended release gabapentin (G-ER) 1800 mg once-daily administered in the evening; (2) G-ER 1800 mg asymmetric divided dose (600 mg AM and 1200 mg PM); or (3) placebo G-ER." | 9.14 | Assessment of pain quality in a clinical trial of gabapentin extended release for postherpetic neuralgia. ( Chiang, YK; Jensen, MP; Wu, J, 2009) |
| " We tested the ability of quantitative sensory testing to predict the analgesic effect of pregabalin and placebo in patients with chronic pancreatitis." | 7.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "Sixty-four patients with painful chronic pancreatitis received pregabalin (150-300 mg BID) or matching placebo for three consecutive weeks." | 7.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "The present study provides first evidence that quantitative sensory testing predicts the analgesic effect of pregabalin in patients with painful chronic pancreatitis." | 7.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "The purpose of this study was to estimate the gamma-aminobutyric acid (GABA) and glutamate plus glutamine (Glx) concentrations in the cortical tubers of patients with tuberous sclerosis complex (TSC) using the MEGA-editing J-difference method and a stimulated echo-acquisition mode with a short echo time, and to determine which abnormality was more dominant between GABA and Glx in patients with TSC with epilepsy." | 7.75 | High gamma-aminobutyric acid level in cortical tubers in epileptic infants with tuberous sclerosis complex measured with the MEGA-editing J-difference method and a three-Tesla clinical MRI Instrument. ( Harada, M; Kubo, H; Matsuda, T; Mori, K; Nishitani, H; Nose, A; Taki, MM, 2009) |
| "Our experience suggests that gabapentin offers an effective therapeutic alternative for the alleviation of neuropathic pain following spinal cord injury." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Seventy-six per cent of patients receiving gabapentin reported a reduction in neuropathic pain." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Data were retrieved from the medical records of all spinal cord injury patients prescribed gabapentin for neuropathic pain." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "To present two years of experience in the use of gabapentin for the alleviation of neuropathic pain in spinal cord injury patients." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Pain was assessed prior to and during treatment at 1, 3 and 6 months with a 10 cm visual analogue scale which ranged from 0 ('no pain') to 10 ('worst pain imaginable'), or by the documentation of a verbal description of pain." | 5.31 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "One hundred fifty-eight patients with moderate-to-severe postherpetic neuralgia were randomly assigned to 1 of 3 treatment conditions: (1) extended release gabapentin (G-ER) 1800 mg once-daily administered in the evening; (2) G-ER 1800 mg asymmetric divided dose (600 mg AM and 1200 mg PM); or (3) placebo G-ER." | 5.14 | Assessment of pain quality in a clinical trial of gabapentin extended release for postherpetic neuralgia. ( Chiang, YK; Jensen, MP; Wu, J, 2009) |
| " We tested the ability of quantitative sensory testing to predict the analgesic effect of pregabalin and placebo in patients with chronic pancreatitis." | 3.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "Sixty-four patients with painful chronic pancreatitis received pregabalin (150-300 mg BID) or matching placebo for three consecutive weeks." | 3.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "The present study provides first evidence that quantitative sensory testing predicts the analgesic effect of pregabalin in patients with painful chronic pancreatitis." | 3.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "The purpose of this study was to estimate the gamma-aminobutyric acid (GABA) and glutamate plus glutamine (Glx) concentrations in the cortical tubers of patients with tuberous sclerosis complex (TSC) using the MEGA-editing J-difference method and a stimulated echo-acquisition mode with a short echo time, and to determine which abnormality was more dominant between GABA and Glx in patients with TSC with epilepsy." | 3.75 | High gamma-aminobutyric acid level in cortical tubers in epileptic infants with tuberous sclerosis complex measured with the MEGA-editing J-difference method and a three-Tesla clinical MRI Instrument. ( Harada, M; Kubo, H; Matsuda, T; Mori, K; Nishitani, H; Nose, A; Taki, MM, 2009) |
| "Our experience suggests that gabapentin offers an effective therapeutic alternative for the alleviation of neuropathic pain following spinal cord injury." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Seventy-six per cent of patients receiving gabapentin reported a reduction in neuropathic pain." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Data were retrieved from the medical records of all spinal cord injury patients prescribed gabapentin for neuropathic pain." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "To present two years of experience in the use of gabapentin for the alleviation of neuropathic pain in spinal cord injury patients." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "A sensitive validated liquid chromatography-tandem mass spectrometric method (LC-MS/MS) for gabapentin (GB) in human plasma has been developed and applied to pharmacokinetic (PK) and bioequivalence (BE) studies in human." | 2.73 | Validated LC-MS/MS method for quantification of gabapentin in human plasma: application to pharmacokinetic and bioequivalence studies in Korean volunteers. ( Jhee, OH; Kang, JS; Kim, KH; Kim, YS; Lee, JH; Lee, JS; Lee, MH; Park, JH; Park, SH; Shaw, LM, 2007) |
| " Chronic administration of vigabatrin in rats has demonstrated these ocular events are result of GABA accumulation and depletion of taurine levels in retinal tissues." | 1.48 | RP-HPLC method for simultaneous estimation of vigabatrin, gamma-aminobutyric acid and taurine in biological samples. ( Narasimha Murthy, S; Police, A; Shankar, VK, 2018) |
| "The optimal GABA+ cut-off value for migraine was 1." | 1.42 | Elevated levels of GABA+ in migraine detected using (1) H-MRS. ( Aguila, ME; Brennan, PC; Hübscher, M; Lagopoulos, J; Leaver, AM; Rebbeck, T; Refshauge, KM, 2015) |
| "IDCs display the risk of a patient violating the target concentration range for any dosage regimen." | 1.39 | Validation of a novel approach for dose individualization in pharmacotherapy using gabapentin in a proof of principles study. ( Anaissie, EJ; Blau, GE; Fausel, C; Laínez, JM; Orcun, S; Reklaitis, GV; Suvannasankha, A, 2013) |
| " The dose amount and dosing interval must be adjusted to maximize the probability of staying within the target concentration range." | 1.39 | Validation of a novel approach for dose individualization in pharmacotherapy using gabapentin in a proof of principles study. ( Anaissie, EJ; Blau, GE; Fausel, C; Laínez, JM; Orcun, S; Reklaitis, GV; Suvannasankha, A, 2013) |
| "To demonstrate the premise of individualized dosing charts (IDCs) as a clinical-bedside decision-support tool to individualize dosage regimens for drugs in which the interpatient variability is controlled by the pharmacokinetic (PK) behavior of the patient, to calculate the optimal sampling schedule (OSS), which minimizes the number of blood samples per patient." | 1.39 | Validation of a novel approach for dose individualization in pharmacotherapy using gabapentin in a proof of principles study. ( Anaissie, EJ; Blau, GE; Fausel, C; Laínez, JM; Orcun, S; Reklaitis, GV; Suvannasankha, A, 2013) |
| "Mexiletine was used as the internal standard." | 1.37 | Highly sensitive determination and validation of gabapentin in pharmaceutical preparations by HPLC with 4-fluoro-7-nitrobenzofurazan derivatization and fluorescence detection. ( Kel, E; Ulu, ST, 2011) |
| "Melatonin was detected in 45% of the fully developed purple, postvéraison grapes but only found in 23% of prelag phase samples." | 1.36 | Changes in the levels of indoleamine phytochemicals during véraison and ripening of wine grapes. ( Hall, BA; Le, CH; Murch, SJ; Saxena, PK, 2010) |
| "Gabapentin was quantified using pre-column derivatization with 1-fluoro-2,4-dinitrobenzene following protein precipitation of plasma with acetonitrile." | 1.34 | Validated HPLC method for the determination of gabapentin in human plasma using pre-column derivatization with 1-fluoro-2,4-dinitrobenzene and its application to a pharmacokinetic study. ( Jahangiri, A; Jalalizadeh, H; Souri, E; Tehrani, MB, 2007) |
| "Gabapentin was quantified after pre-column derivatization with 1-fluoro-2,4-dinitrobenzene." | 1.34 | Optimization of an HPLC method for determination of gabapentin in dosage forms through derivatization with 1-fluoro-2,4-dinitrobenzene. ( Jalalizadeh, H; Shafiee, A; Souri, E, 2007) |
| "A rapid, sensitive and accurate high performance liquid chromatography with UV detection method was developed and validated for the quantification of gabapentin in dosage forms." | 1.34 | Optimization of an HPLC method for determination of gabapentin in dosage forms through derivatization with 1-fluoro-2,4-dinitrobenzene. ( Jalalizadeh, H; Shafiee, A; Souri, E, 2007) |
| " The method was successfully applied to the analysis of gabapentin in plasma from dosed patients for therapeutic drug monitoring." | 1.33 | Simple and sensitive liquid chromatographic method with fluorimetric detection for the analysis of gabapentin in human plasma. ( Chung, TC; Tai, CT; Wu, HL, 2006) |
| "Gabapentin (GBP) is an anticonvulsant and widely used in the treatment of epilepsy." | 1.33 | Simple and sensitive liquid chromatographic method with fluorimetric detection for the analysis of gabapentin in human plasma. ( Chung, TC; Tai, CT; Wu, HL, 2006) |
| "Pain was assessed prior to and during treatment at 1, 3 and 6 months with a 10 cm visual analogue scale which ranged from 0 ('no pain') to 10 ('worst pain imaginable'), or by the documentation of a verbal description of pain." | 1.31 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Gabapentin (GBP) is a new antiepileptic drug approved for clinical treatment of partial seizures in the USA." | 1.30 | Rapid high-performance liquid chromatographic determination of serum gabapentin. ( Jiang, Q; Li, S, 1999) |
| " Octanol produced a shift of the current dose-response curve toward lower concentrations of GABA." | 1.29 | Selective effects of alcohols on gamma-aminobutyric acid A receptor subunits expressed in human embryonic kidney cells. ( Carter, DB; Hamilton, BJ; Kurata, Y; Marszalec, W; Narahashi, T, 1994) |
| " polylepis were toxic as determined by all four test methods." | 1.29 | Toxicity of four potentially ichthyotoxic marine phytoflagellates determined by four different test methods. ( Edvardsen, B; Fonnum, F; Meldahl, AS, 1994) |
| " Cumulative dose-response curves for chlordiazepoxide were obtained before and during chronic chlordiazepoxide administration and during chronic saline administration." | 1.29 | Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity. ( Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL, 1993) |
| " The optimized methods show good linearity, precision (RSD < 2%) and accuracy (bias < 2% for dosage forms)." | 1.29 | Validation of high-performance liquid chromatographic methods on two silica base-deactivated reversed phases for the determination of chloroprocaine and bupivacaine. ( Brun, F; Veuthey, JL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 52 (29.55) | 18.2507 |
| 2000's | 78 (44.32) | 29.6817 |
| 2010's | 46 (26.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Qi, ZH | 1 |
| Song, M | 1 |
| Wallace, MJ | 1 |
| Wang, D | 2 |
| Newton, PM | 1 |
| McMahon, T | 1 |
| Chou, WH | 1 |
| Zhang, C | 1 |
| Shokat, KM | 1 |
| Messing, RO | 1 |
| Sun, D | 1 |
| Yang, J | 3 |
| Li, X | 1 |
| Wang, L | 1 |
| Yu, Q | 1 |
| Qin, S | 1 |
| Tang, R | 1 |
| Passarelli, MK | 1 |
| Pirkl, A | 1 |
| Moellers, R | 1 |
| Grinfeld, D | 1 |
| Kollmer, F | 1 |
| Havelund, R | 1 |
| Newman, CF | 1 |
| Marshall, PS | 1 |
| Arlinghaus, H | 1 |
| Alexander, MR | 1 |
| West, A | 1 |
| Horning, S | 1 |
| Niehuis, E | 1 |
| Makarov, A | 1 |
| Dollery, CT | 1 |
| Gilmore, IS | 1 |
| Police, A | 1 |
| Shankar, VK | 1 |
| Narasimha Murthy, S | 1 |
| Moheet, A | 1 |
| Emir, UE | 1 |
| Terpstra, M | 1 |
| Kumar, A | 1 |
| Eberly, LE | 1 |
| Seaquist, ER | 1 |
| Öz, G | 1 |
| Olesen, SS | 1 |
| Graversen, C | 1 |
| Bouwense, SA | 1 |
| van Goor, H | 1 |
| Wilder-Smith, OH | 1 |
| Drewes, AM | 1 |
| Blau, GE | 1 |
| Orcun, S | 1 |
| Laínez, JM | 1 |
| Reklaitis, GV | 1 |
| Suvannasankha, A | 1 |
| Fausel, C | 1 |
| Anaissie, EJ | 1 |
| Hall, EL | 1 |
| Stephenson, MC | 1 |
| Price, D | 1 |
| Morris, PG | 1 |
| Gaetz, W | 1 |
| Bloy, L | 1 |
| Wang, DJ | 1 |
| Port, RG | 1 |
| Blaskey, L | 1 |
| Levy, SE | 1 |
| Roberts, TP | 1 |
| Harris, AD | 3 |
| Glaubitz, B | 1 |
| Near, J | 2 |
| John Evans, C | 1 |
| Puts, NA | 6 |
| Schmidt-Wilcke, T | 1 |
| Tegenthoff, M | 1 |
| Barker, PB | 9 |
| Edden, RA | 11 |
| Huang, F | 1 |
| Li, J | 1 |
| Shi, HL | 1 |
| Wang, TT | 1 |
| Muhtar, W | 1 |
| Du, M | 1 |
| Zhang, BB | 1 |
| Wu, H | 1 |
| Yang, L | 1 |
| Hu, ZB | 1 |
| Wu, XJ | 1 |
| Zhang, DK | 1 |
| Chen, M | 1 |
| Liu, Y | 1 |
| Wang, RF | 1 |
| Liu, LP | 1 |
| Li, M | 1 |
| Ikeda, K | 1 |
| Ikawa, K | 1 |
| Yokoshige, S | 1 |
| Yoshikawa, S | 1 |
| Morikawa, N | 1 |
| Simmons, RM | 1 |
| Forster, B | 1 |
| Guo, W | 1 |
| Knopp, KL | 1 |
| Deeb, S | 1 |
| McKeown, DA | 1 |
| Torrance, HJ | 1 |
| Wylie, FM | 1 |
| Logan, BK | 1 |
| Scott, KS | 1 |
| Lin, X | 1 |
| Cai, Y | 1 |
| Yan, J | 1 |
| Zhang, L | 2 |
| Wu, D | 1 |
| Li, H | 2 |
| Evans, CJ | 5 |
| Aguila, ME | 1 |
| Lagopoulos, J | 1 |
| Leaver, AM | 1 |
| Rebbeck, T | 1 |
| Hübscher, M | 1 |
| Brennan, PC | 1 |
| Refshauge, KM | 1 |
| Sawiak, SJ | 1 |
| Jupp, B | 1 |
| Taylor, T | 1 |
| Caprioli, D | 1 |
| Carpenter, TA | 1 |
| Dalley, JW | 1 |
| Shungu, DC | 1 |
| Mao, X | 1 |
| Gonzales, R | 1 |
| Soones, TN | 1 |
| Dyke, JP | 1 |
| van der Veen, JW | 2 |
| Kegeles, LS | 1 |
| Grewal, M | 1 |
| Dabas, A | 1 |
| Saharan, S | 1 |
| Mandal, PK | 1 |
| Greenhouse, I | 1 |
| Noah, S | 1 |
| Maddock, RJ | 1 |
| Ivry, RB | 1 |
| Prinsen, H | 1 |
| de Graaf, RA | 1 |
| Mason, GF | 1 |
| Pelletier, D | 1 |
| Juchem, C | 1 |
| Mikkelsen, M | 1 |
| Singh, KD | 1 |
| Brealy, JA | 1 |
| Linden, DE | 1 |
| Tomiyasu, M | 1 |
| Aida, N | 1 |
| Shibasaki, J | 1 |
| Umeda, M | 1 |
| Murata, K | 1 |
| Heberlein, K | 1 |
| Brown, MA | 1 |
| Shimizu, E | 1 |
| Tsuji, H | 1 |
| Obata, T | 1 |
| Chan, KL | 1 |
| Oeltzschner, G | 1 |
| Schär, M | 1 |
| Gussew, A | 1 |
| Rzanny, R | 1 |
| Scholle, HC | 1 |
| Kaiser, WA | 1 |
| Reichenbach, JR | 1 |
| Zhang, Y | 3 |
| Holliman, C | 1 |
| Tang, D | 1 |
| Fast, D | 1 |
| Michael, S | 1 |
| Qiu, T | 1 |
| Cao, Y | 1 |
| Huang, Z | 1 |
| Taki, MM | 1 |
| Harada, M | 1 |
| Mori, K | 1 |
| Kubo, H | 1 |
| Nose, A | 1 |
| Matsuda, T | 1 |
| Nishitani, H | 1 |
| Buck, K | 1 |
| Voehringer, P | 1 |
| Ferger, B | 1 |
| Jensen, MP | 1 |
| Chiang, YK | 1 |
| Wu, J | 1 |
| Snyder, J | 1 |
| Hanstock, CC | 1 |
| Wilman, AH | 1 |
| Wang, J | 1 |
| Mohamadi, MR | 1 |
| Kaji, N | 1 |
| Tokeshi, M | 1 |
| Baba, Y | 1 |
| Blanc, F | 1 |
| Ruppert, E | 1 |
| Kleitz, C | 1 |
| Valenti, MP | 1 |
| Cretin, B | 1 |
| Humbel, RL | 1 |
| Honnorat, J | 1 |
| Namer, IJ | 1 |
| Hirsch, E | 1 |
| Manning, L | 1 |
| de Seze, J | 1 |
| McGonigle, DJ | 2 |
| Zhang, W | 2 |
| Mifflin, S | 1 |
| Cui, W | 1 |
| Chen, X | 1 |
| Zhan, Y | 1 |
| Zhang, Z | 1 |
| Zhong, D | 1 |
| Dousa, M | 1 |
| Gibala, P | 1 |
| Lemr, K | 1 |
| Murch, SJ | 1 |
| Hall, BA | 1 |
| Le, CH | 1 |
| Saxena, PK | 1 |
| Abdulrahman, SA | 1 |
| Basavaiah, K | 1 |
| Zhu, KY | 1 |
| Fu, Q | 1 |
| Leung, KW | 1 |
| Wong, ZC | 1 |
| Choi, RC | 1 |
| Tsim, KW | 1 |
| Ulu, ST | 1 |
| Kel, E | 1 |
| Dahl, SR | 1 |
| Olsen, KM | 1 |
| Strand, DH | 1 |
| Aufhaus, E | 1 |
| Weber-Fahr, W | 1 |
| Sack, M | 1 |
| Tunc-Skarka, N | 1 |
| Oberthuer, G | 1 |
| Hoerst, M | 1 |
| Meyer-Lindenberg, A | 1 |
| Boettcher, U | 1 |
| Ende, G | 1 |
| Pan, JW | 2 |
| Duckrow, RB | 1 |
| Spencer, DD | 1 |
| Avdievich, NI | 1 |
| Hetherington, HP | 2 |
| Mudiam, MK | 1 |
| Chauhan, A | 1 |
| Jain, R | 1 |
| Ch, R | 1 |
| Fatima, G | 1 |
| Malhotra, E | 1 |
| Murthy, RC | 1 |
| Coune, PG | 1 |
| Craveiro, M | 1 |
| Gaugler, MN | 1 |
| Mlynárik, V | 1 |
| Schneider, BL | 1 |
| Aebischer, P | 1 |
| Gruetter, R | 2 |
| Napolitano, A | 1 |
| Kockenberger, W | 1 |
| Auer, DP | 1 |
| Intrapiromkul, J | 1 |
| Zhu, H | 1 |
| Cheng, Y | 1 |
| Mullins, PG | 1 |
| O'Gorman, RL | 1 |
| Vidyasagar, R | 1 |
| Watanabe, H | 2 |
| Takaya, N | 2 |
| Mitsumori, F | 2 |
| Shen, J | 2 |
| Zunker, P | 1 |
| Golombeck, K | 1 |
| Brossmann, J | 1 |
| Georgiadis, D | 1 |
| Deuschl, G | 1 |
| Zhu, Z | 1 |
| Neirinck, L | 1 |
| Swadlow, HA | 1 |
| Liu, HW | 1 |
| Welch, JW | 1 |
| Bhakoo, K | 1 |
| Dixon, RM | 1 |
| Styles, P | 1 |
| Sibson, NR | 1 |
| Blamire, AM | 1 |
| Khuhawar, MY | 1 |
| Rajper, AD | 1 |
| Chang, SY | 1 |
| Wang, FY | 1 |
| Drafts, BC | 1 |
| Fisher, JL | 1 |
| Du, F | 1 |
| Chu, WJ | 1 |
| Yang, B | 1 |
| Den Hollander, JA | 1 |
| Ng, TC | 1 |
| Bravo, DT | 1 |
| Harris, DO | 1 |
| Parsons, SM | 1 |
| Bielicki, G | 1 |
| Chassain, C | 1 |
| Renou, JP | 1 |
| Farges, MC | 1 |
| Vasson, MP | 1 |
| Eschalier, A | 2 |
| Durif, F | 1 |
| Vaccher, MP | 1 |
| Lipka, E | 1 |
| Bonte, JP | 1 |
| Vaccher, C | 1 |
| Zacharis, CK | 1 |
| Theodoridis, GA | 1 |
| Voulgaropoulos, AN | 1 |
| Mao, Y | 1 |
| Thompson, MJ | 1 |
| Wang, Q | 1 |
| Tsai, EW | 1 |
| Gambelunghe, C | 1 |
| Mariucci, G | 1 |
| Tantucci, M | 1 |
| Ambrosini, MV | 1 |
| Martin, RJ | 1 |
| Wilson, CG | 1 |
| Abu-Shaweesh, JM | 1 |
| Haxhiu, MA | 1 |
| Chang, T | 1 |
| Lang, B | 1 |
| Murinson, BB | 1 |
| Butler, M | 1 |
| Marfurt, K | 1 |
| Gleason, S | 1 |
| De Camilli, P | 1 |
| Solimena, M | 1 |
| Song, Y | 1 |
| Shenwu, M | 1 |
| Dhossche, DM | 1 |
| Liu, YM | 1 |
| Choi, IY | 2 |
| Lee, SP | 1 |
| Richard, D | 1 |
| Ling, B | 1 |
| Authier, N | 1 |
| Faict, TW | 1 |
| Coudoré, F | 1 |
| Iwano, M | 1 |
| Kanzaki, R | 1 |
| Borrey, DC | 1 |
| Godderis, KO | 1 |
| Engelrelst, VI | 1 |
| Bernard, DR | 1 |
| Langlois, MR | 1 |
| Dahl, JB | 1 |
| Kehlet, H | 1 |
| Yin, XB | 1 |
| Qi, B | 1 |
| Sun, X | 1 |
| Yang, X | 1 |
| Wang, E | 1 |
| Zhan, RZ | 1 |
| Nadler, JV | 1 |
| Schwartz-Bloom, RD | 1 |
| Ehlen, JC | 1 |
| Albers, HE | 1 |
| Breyer, ED | 1 |
| Serena, J | 2 |
| Blanco, M | 1 |
| Castellanos, M | 2 |
| Silva, Y | 1 |
| Vivancos, J | 1 |
| Moro, MA | 1 |
| Leira, R | 2 |
| Lizasoain, I | 1 |
| Castillo, J | 2 |
| Dávalos, A | 2 |
| Patel, KP | 1 |
| Klomp, DW | 1 |
| Renema, WK | 1 |
| van der Graaf, M | 1 |
| de Galan, BE | 1 |
| Kentgens, AP | 1 |
| Heerschap, A | 1 |
| Hyder, F | 1 |
| Patel, AB | 1 |
| Gjedde, A | 1 |
| Rothman, DL | 1 |
| Behar, KL | 1 |
| Shulman, RG | 1 |
| Cebada, J | 1 |
| Alvarado-Alvarez, R | 1 |
| Becerra, E | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| Central Nervous System Uptake of Intranasal Glutathione in Parkinson's Disease[NCT02324426] | Phase 1 | 15 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| A Randomized, Double-blind, Placebo-controlled Trial to Assess the Safety and Efficacy of the Perioperative Administration of Pregabalin in Reducing the Incidence of Postoperative Delirium and Improving Acute Postoperative Pain Management[NCT00819988] | Phase 3 | 240 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures[NCT02957097] | Phase 4 | 0 participants (Actual) | Interventional | 2019-09-30 | Withdrawn (stopped due to Original PI left institution and the PI who took over was not able to initiate the study so it was never started.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
10 reviews available for gamma-aminobutyric acid and Sensitivity and Specificity
| Article | Year |
|---|---|
GABA estimation in the brains of children on the autism spectrum: measurement precision and regional cortical variation.
Topics: Adult; Cerebral Cortex; Child; Child Development Disorders, Pervasive; Female; gamma-Aminobutyric Ac | 2014 |
Plasticity of GABAergic mechanisms within the nucleus of the solitary tract in hypertension.
Topics: Adaptation, Physiological; Animals; Baroreflex; Female; GABA Plasma Membrane Transport Proteins; gam | 2010 |
Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA.
Topics: Algorithms; Brain; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Reproducibility | 2014 |
Fast-spike interneurons and feedforward inhibition in awake sensory neocortex.
Topics: Action Potentials; Afferent Pathways; Animals; Feedback; gamma-Aminobutyric Acid; Interneurons; Mice | 2003 |
Role of inhibitory neurotransmitter interactions in the pathogenesis of neonatal apnea: implications for management.
Topics: Animals; Animals, Newborn; Apnea; Bicuculline; Female; gamma-Aminobutyric Acid; Humans; Infant, Newb | 2004 |
Role of paraventricular nucleus in mediating sympathetic outflow in heart failure.
Topics: Animals; Cardiac Output, Low; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Heart; Heart | 2000 |
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Topics: Animals; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; M | 2006 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Detection of hidden metabolites by localized proton magnetic resonance spectroscopy in vivo.
Topics: Adult; Brain; gamma-Aminobutyric Acid; Humans; Image Enhancement; Magnetic Resonance Spectroscopy; M | 1997 |
Similarities and interactions between GABAergic and glutaminergic systems.
Topics: Animals; Central Nervous System; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Humans; | 1998 |
7 trials available for gamma-aminobutyric acid and Sensitivity and Specificity
| Article | Year |
|---|---|
Assessment of pain quality in a clinical trial of gabapentin extended release for postherpetic neuralgia.
Topics: Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Delayed-Action Preparations; Dose-Response Re | 2009 |
Post-partum cerebral angiopathy: repetitive TCD, MRI, MRA, and EEG examinations.
Topics: Acetates; Adult; Amines; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Aspirin; Brain Ed | 2002 |
The prediction of malignant cerebral infarction by molecular brain barrier disruption markers.
Topics: Aged; Biomarkers; Blood-Brain Barrier; Brain; Case-Control Studies; Edema; Female; Fibronectins; gam | 2005 |
Extracellular amino acid changes in patients during reversible cerebral ischaemia.
Topics: Adult; Aged; Amino Acids; Biomarkers; Brain; Extracellular Fluid; Female; gamma-Aminobutyric Acid; G | 2005 |
Validated LC-MS/MS method for quantification of gabapentin in human plasma: application to pharmacokinetic and bioequivalence studies in Korean volunteers.
Topics: Administration, Oral; Amines; Anticonvulsants; Atmospheric Pressure; Cross-Over Studies; Cyclohexane | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Use of gabapentin for perioperative pain control -- a meta-analysis.
Topics: Adult; Amines; Analgesics; Confidence Intervals; Cyclohexanecarboxylic Acids; Double-Blind Method; F | 2007 |
Neurological deterioration in acute lacunar infarctions: the role of excitatory and inhibitory neurotransmitters.
Topics: Acute Disease; Aged; Brain Infarction; Disease Progression; Female; gamma-Aminobutyric Acid; Glutami | 2001 |
160 other studies available for gamma-aminobutyric acid and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Benzodiazepines; Cells, Cultured; Enzyme Act | 2007 |
Gabapentin regulates expression of FGF2 and FGFR1 in dorsal root ganglia via microRNA-15a in the arthritis rat model.
Topics: Amines; Animals; Arthritis, Experimental; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fibro | 2017 |
The 3D OrbiSIMS-label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power.
Topics: Amiodarone; Animals; Cells, Cultured; Dopamine; Equipment Design; Female; gamma-Aminobutyric Acid; G | 2017 |
RP-HPLC method for simultaneous estimation of vigabatrin, gamma-aminobutyric acid and taurine in biological samples.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; gamma | 2018 |
Initial experience with seven tesla magnetic resonance spectroscopy of hypothalamic GABA during hyperinsulinemic euglycemia and hypoglycemia in healthy humans.
Topics: Adult; Blood Glucose; Female; gamma-Aminobutyric Acid; Humans; Hyperinsulinism; Hypoglycemia; Hypoth | 2014 |
Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis.
Topics: Adult; Analgesics; Electric Stimulation; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; | 2013 |
Validation of a novel approach for dose individualization in pharmacotherapy using gabapentin in a proof of principles study.
Topics: Amines; Analgesics; Bayes Theorem; Cyclohexanecarboxylic Acids; Decision Support Techniques; Dose-Re | 2013 |
Methodology for improved detection of low concentration metabolites in MRS: optimised combination of signals from multi-element coil arrays.
Topics: Algorithms; Cerebral Cortex; Equipment Design; Equipment Failure Analysis; gamma-Aminobutyric Acid; | 2014 |
Impact of frequency drift on gamma-aminobutyric acid-edited MR spectroscopy.
Topics: Adult; Algorithms; Artifacts; Brain; Female; gamma-Aminobutyric Acid; Humans; Macromolecular Substan | 2014 |
Simultaneous quantification of seven hippocampal neurotransmitters in depression mice by LC-MS/MS.
Topics: Animals; Chromatography, Liquid; Depressive Disorder; Disease Models, Animal; Dopamine; gamma-Aminob | 2014 |
Acoustic radiation force impulse elastography for non-invasive assessment of disease stage in patients with primary biliary cirrhosis: A preliminary study.
Topics: Biopsy; Elasticity Imaging Techniques; Female; gamma-Aminobutyric Acid; Humans; Liver; Liver Cirrhos | 2014 |
Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care.
Topics: Acetamides; Amines; Cyclohexanecarboxylic Acids; Dried Blood Spot Testing; Fluoroacetates; Gabapenti | 2014 |
A method to enhance the magnitude of tactile hypersensitivity following spinal nerve ligation in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2014 |
Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases.
Topics: Amines; Anticonvulsants; Carbamazepine; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Drug Mo | 2014 |
Determination of Gabapentin in Human Plasma and Urine by Capillary Electrophoresis with Laser-Induced Fluorescence Detection.
Topics: Amines; Cyclohexanecarboxylic Acids; Electrophoresis, Capillary; Gabapentin; gamma-Aminobutyric Acid | 2015 |
Spectral-editing measurements of GABA in the human brain with and without macromolecule suppression.
Topics: Adult; Algorithms; Cerebral Cortex; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Magn | 2015 |
Gannet: A batch-processing tool for the quantitative analysis of gamma-aminobutyric acid–edited MR spectroscopy spectra.
Topics: Adult; Algorithms; Brain; Data Interpretation, Statistical; Female; gamma-Aminobutyric Acid; Humans; | 2014 |
Elevated levels of GABA+ in migraine detected using (1) H-MRS.
Topics: Adult; Biomarkers; Brain; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Migraine Disor | 2015 |
In vivo γ-aminobutyric acid measurement in rats with spectral editing at 4.7T.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Image Interpretation, Computer-Assisted; Magnetic Resonance | 2016 |
Brain γ-aminobutyric acid (GABA) detection in vivo with the J-editing (1) H MRS technique: a comprehensive methodological evaluation of sensitivity enhancement, macromolecule contamination and test-retest reliability.
Topics: Adult; Algorithms; Female; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Magnetic Reso | 2016 |
GABA quantitation using MEGA-PRESS: Regional and hemispheric differences.
Topics: Adult; Cerebrum; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Male; Molecula | 2016 |
Individual differences in GABA content are reliable but are not uniform across the human cortex.
Topics: Cerebral Cortex; gamma-Aminobutyric Acid; Humans; Image Interpretation, Computer-Assisted; Magnetic | 2016 |
Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T.
Topics: Adult; Biomarkers; Brain; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Humans; Magne | 2017 |
Quantification of γ-aminobutyric acid (GABA) in
Topics: Adult; Algorithms; Female; gamma-Aminobutyric Acid; Gray Matter; Humans; Magnetic Resonance Imaging; | 2016 |
In vivo estimation of gamma-aminobutyric acid levels in the neonatal brain.
Topics: Algorithms; Artifacts; Brain; Female; gamma-Aminobutyric Acid; Humans; Image Interpretation, Compute | 2017 |
Spatial Hadamard encoding of J-edited spectroscopy using slice-selective editing pulses.
Topics: Adult; Algorithms; Brain; Female; gamma-Aminobutyric Acid; Glutathione; Humans; Lactic Acid; Magneti | 2017 |
[Quantitation of glutamate in the brain by using MR proton spectroscopy at 1.5 T and 3 T].
Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Cerebral Cortex; Dominance, Cerebral; Female; gamma-Amin | 2008 |
Development and validation of a direct enantiomeric separation of pregabalin to support isolated perfused rat kidney studies.
Topics: Animals; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; | 2008 |
Pre-staining paper chromatography method for quantification of gamma-aminobutyric acid.
Topics: Chromatography, High Pressure Liquid; Chromatography, Paper; Copper; gamma-Aminobutyric Acid; Indica | 2009 |
High gamma-aminobutyric acid level in cortical tubers in epileptic infants with tuberous sclerosis complex measured with the MEGA-editing J-difference method and a three-Tesla clinical MRI Instrument.
Topics: Biomarkers; Cerebral Cortex; Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Acid; Hum | 2009 |
Rapid analysis of GABA and glutamate in microdialysis samples using high performance liquid chromatography and tandem mass spectrometry.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Male; | 2009 |
Spectral editing of weakly coupled spins using variable flip angles in PRESS constant echo time difference spectroscopy: application to GABA.
Topics: Algorithms; Brain Chemistry; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Sensi | 2009 |
Exceeding 20,000-fold concentration of protein by the on-line isotachophoresis concentration in poly(methyl methacrylate) microchip.
Topics: Antibodies, Monoclonal; Electrolytes; Electrophoresis; gamma-Aminobutyric Acid; Immunoassay; Methylc | 2009 |
Acute limbic encephalitis and glutamic acid decarboxylase antibodies: a reality?
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Autoantibodies; Biomarkers; Electroencephalography; | 2009 |
Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex.
Topics: Child; Circadian Rhythm; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; M | 2010 |
Determination of picamilon concentration in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Acetaminophen; Chemical Fractionation; Chromatography, Liquid; Drug Stability; gamma-Aminobutyric Ac | 2010 |
Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde.
Topics: Calibration; Chromatography, High Pressure Liquid; Drug Contamination; gamma-Aminobutyric Acid; Limi | 2010 |
Changes in the levels of indoleamine phytochemicals during véraison and ripening of wine grapes.
Topics: gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Melatonin; Plant Extracts; Regression | 2010 |
Sensitive and selective spectrophotometric assay of gabapentin in capsules using sodium 1, 2-naphthoquinone-4-sulfonate.
Topics: Amines; Anticonvulsants; Buffers; Capsules; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobuty | 2011 |
The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry.
Topics: Animals; Brain Chemistry; Chromatography, Liquid; Dopamine; Drug Stability; Embryo, Mammalian; Epine | 2011 |
Highly sensitive determination and validation of gabapentin in pharmaceutical preparations by HPLC with 4-fluoro-7-nitrobenzofurazan derivatization and fluorescence detection.
Topics: 4-Chloro-7-nitrobenzofurazan; Amines; Capsules; Chromatography, High Pressure Liquid; Cyclohexanecar | 2011 |
Determination of γ-hydroxybutyrate (GHB), β-hydroxybutyrate (BHB), pregabalin, 1,4-butane-diol (1,4BD) and γ-butyrolactone (GBL) in whole blood and urine samples by UPLC-MSMS.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Butylene Glycols; Chromatography, High Pressure Liquid; gamm | 2012 |
Absence of changes in GABA concentrations with age and gender in the human anterior cingulate cortex: a MEGA-PRESS study with symmetric editing pulse frequencies for macromolecule suppression.
Topics: Adult; Aging; Algorithms; Female; gamma-Aminobutyric Acid; Gyrus Cinguli; Humans; Macromolecular Sub | 2013 |
Selective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T.
Topics: Algorithms; Brain; Epilepsy; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Neuro | 2013 |
Development, validation and comparison of two microextraction techniques for the rapid and sensitive determination of pregabalin in urine and pharmaceutical formulations after ethyl chloroformate derivatization followed by gas chromatography-mass spectrom
Topics: Analgesics; Anticonvulsants; Chemistry, Pharmaceutical; Dosage Forms; Formic Acid Esters; gamma-Amin | 2012 |
An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.
Topics: alpha-Synuclein; Animals; Biomarkers; Brain; Early Diagnosis; Female; gamma-Aminobutyric Acid; Magne | 2013 |
Macromolecule-suppressed GABA-edited magnetic resonance spectroscopy at 3T.
Topics: Adult; Algorithms; Artifacts; Brain Chemistry; Female; gamma-Aminobutyric Acid; Humans; Macromolecul | 2012 |
Reliable gamma aminobutyric acid measurement using optimized PRESS at 3 T.
Topics: Algorithms; Brain Chemistry; Computer Simulation; gamma-Aminobutyric Acid; Humans; Magnetic Resonanc | 2013 |
J-difference editing of gamma-aminobutyric acid (GABA): simulated and experimental multiplet patterns.
Topics: Algorithms; Computer Simulation; gamma-Aminobutyric Acid; Magnetic Resonance Spectroscopy; Models, C | 2013 |
Determining the in vivo transverse relaxation time of GABA in the human brain at 7T.
Topics: Adult; Algorithms; Brain Chemistry; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imag | 2013 |
Highly resolved two-dimensional ¹H spectroscopy of the human brain using ISIS CT-PRESS with resolution enhancement.
Topics: Brain; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Enhancement; Magnetic Resona | 2012 |
Regional difference in GABA levels between medial prefrontal and occipital cortices.
Topics: Adult; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spect | 2013 |
High-performance liquid chromatographic method for the determination of gabapentin in human plasma.
Topics: Acetates; Amines; Anticonvulsants; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids | 2002 |
[Determination of 4-aminobutyric acid in pumpkin powder by high performance liquid chromatography].
Topics: Cation Exchange Resins; Chromatography, High Pressure Liquid; Cucurbita; gamma-Aminobutyric Acid; Po | 2001 |
In vivo monitoring of rat brain metabolites during vigabatrin treatment using localized 2D-COSY.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamine; Magnetic Resonance Spectroscopy; Male; Rats; Rat | 2003 |
Liquid chromatographic determination of gamma-aminobutyric acid in cerebrospinal fluid using 2-hydroxynaphthaldehyde as derivatizing reagent.
Topics: Aldehydes; Calibration; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Humans; Indic | 2003 |
Determination of gabapentin in human plasma by capillary electrophoresis with laser-induced fluorescence detection and acetonitrile stacking technique.
Topics: Acetates; Acetonitriles; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Electrophoresis, Capi | 2004 |
Structural determinants of the pharmacological properties of the GABAA receptor alpha6 subunit.
Topics: Amiloride; Binding, Competitive; Cells, Cultured; gamma-Aminobutyric Acid; Humans; Mutation; Protein | 2004 |
In vivo GABA detection with improved selectivity and sensitivity by localized double quantum filter technique at 4.1T.
Topics: Creatine; gamma-Aminobutyric Acid; Glutathione; Humans; Magnetic Resonance Spectroscopy; Occipital L | 2004 |
Reliable, sensitive, rapid and quantitative enzyme-based assay for gamma-hydroxybutyric acid (GHB).
Topics: Central Nervous System Depressants; Chromatography, Affinity; Cloning, Molecular; Cupriavidus necato | 2004 |
Brain GABA editing by localized in vivo (1)H magnetic resonance spectroscopy.
Topics: Administration, Oral; Algorithms; Animals; Brain; Female; gamma-Aminobutyric Acid; Macaca mulatta; M | 2004 |
Chiral capillary electrophoretic resolution of baclofen, gabaergic ligand, using highly sulfated cyclodextrins.
Topics: Baclofen; Buffers; Cyclodextrins; Electrophoresis, Capillary; GABA Agonists; gamma-Aminobutyric Acid | 2004 |
On-line coupling of sequential injection with liquid chromatography for the automated derivatization and determination of gamma-aminobutyric acid in human biological fluids.
Topics: Automation; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Humans; Reproducibility o | 2004 |
Quantitation of poloxamers in pharmaceutical formulations using size exclusion chromatography and colorimetric methods.
Topics: Amines; Biphenyl Compounds; Chromatography, Gel; Colorimetry; Cyclohexanecarboxylic Acids; Ephedrine | 2004 |
Gas chromatography-tandem mass spectrometry analysis of gabapentin in serum.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Gas Chromatograph | 2005 |
GAD antibodies in stiff-person syndrome.
Topics: Autoantibodies; Autoantigens; Autoimmune Diseases; Cohort Studies; gamma-Aminobutyric Acid; Glutamat | 2004 |
Markedly elevated GAD antibodies in SPS: effects of age and illness duration.
Topics: Age Factors; Antibody Specificity; Autoantibodies; Autoantigens; Autoimmune Diseases; Blotting, West | 2004 |
A capillary liquid chromatographic/tandem mass spectrometric method for the quantification of gamma-aminobutyric acid in human plasma and cerebrospinal fluid.
Topics: Calibration; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Humans; Reference Standa | 2005 |
Selective homonuclear Hartmann-Hahn transfer method for in vivo spectral editing in the human brain.
Topics: Brain Chemistry; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Phantoms, Imaging | 2005 |
GC/MS profiling of gamma-hydroxybutyrate and precursors in various animal tissues using automatic solid-phase extraction. Preliminary investigations of its potential interest in postmortem interval determination.
Topics: 4-Butyrolactone; Animal Structures; Animals; Butylene Glycols; Calibration; Central Nervous System; | 2005 |
Immunocytochemical identification of neuroactive substances in the antennal lobe of the male silkworm moth Bombyx mori.
Topics: Animals; Bombyx; Brain; FMRFamide; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Immunohistochemis | 2005 |
Quantitative determination of vigabatrin and gabapentin in human serum by gas chromatography-mass spectrometry.
Topics: Amines; Calibration; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Gas Chromatog | 2005 |
Comment on: Gilron I, Orr E, Tu D, O'Neill JP, Zamora JE, Bell AC. A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hyste
Topics: Adult; Amines; Antiparkinson Agents; Cyclohexanecarboxylic Acids; Cyclooxygenase Inhibitors; Data In | 2005 |
4-(Dimethylamino)butyric acid labeling for electrochemiluminescence detection of biological substances by increasing sensitivity with gold nanoparticle amplification.
Topics: 2,2'-Dipyridyl; 3-Mercaptopropionic Acid; Adsorption; Animals; Avidin; Cattle; Coordination Complexe | 2005 |
Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gramicidin; Hippocampus; Interneurons; Isc | 2006 |
MEKC-LIF of gamma-amino butyric acid in microdialysate: systematic optimization of the separation conditions by factorial analysis.
Topics: Chromatography, Micellar Electrokinetic Capillary; Factor Analysis, Statistical; gamma-Aminobutyric | 2005 |
Sensitivity-enhanced 13C MR spectroscopy of the human brain at 3 Tesla.
Topics: Aspartic Acid; Brain Chemistry; Carbon Isotopes; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; | 2006 |
An improved method for long-term measuring of hemolymph fluctuations of non-essential amino acids, GABA and histamine from freely moving crayfish.
Topics: Amino Acids; Amino Acids, Essential; Animals; Astacoidea; Behavior, Animal; Cells, Cultured; gamma-A | 2006 |
Simple and sensitive liquid chromatographic method with fluorimetric detection for the analysis of gabapentin in human plasma.
Topics: Adult; Aged; Aged, 80 and over; Amines; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic | 2006 |
Sensitive high-performance liquid chromatographic quantitation of gabapentin in human serum using liquid-liquid extraction and pre-column derivatization with 9-fluorenylmethyl chloroformate.
Topics: Amines; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Drug Stability; Fluorenes | 2006 |
Sensitive microanalysis of gabapentin by high-performance liquid chromatography in human serum using pre-column derivatization with 4-chloro-7-nitrobenzofurazan: Application to a bioequivalence study.
Topics: 4-Chloro-7-nitrobenzofurazan; Amines; Anticonvulsants; Chromatography, High Pressure Liquid; Cyclohe | 2006 |
Discrimination of hairpin polyamides with an alpha-substituted-gamma-aminobutyric acid as a 5'-TG-3' reader in DNA minor groove.
Topics: Binding Sites; Binding, Competitive; DNA; gamma-Aminobutyric Acid; Models, Molecular; Molecular Stru | 2006 |
Determination of gabapentin in human plasma and urine by high-performance liquid chromatography with UV-vis detection.
Topics: Amines; Anticonvulsants; Calibration; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Ac | 2006 |
Presence of glutamate, glycine, and gamma-aminobutyric acid in the retina of the larval sea lamprey: comparative immunohistochemical study of classical neurotransmitters in larval and postmetamorphic retinas.
Topics: Animals; Brain; Brain Chemistry; Calbindin 2; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immun | 2006 |
Development and application of a validated HPLC method for the determination of gabapentin and its major degradation impurity in drug products.
Topics: Amines; Analgesics; Anticonvulsants; Capsules; Chromatography, High Pressure Liquid; Cyclohexanecarb | 2007 |
Capillary electrophoretic analysis of gamma-aminobutyric acid and alanine in tea with in-capillary derivatization and fluorescence detection.
Topics: Alanine; Electrophoresis, Capillary; gamma-Aminobutyric Acid; Indicators and Reagents; Mercaptoethan | 2007 |
Validated HPLC method for the determination of gabapentin in human plasma using pre-column derivatization with 1-fluoro-2,4-dinitrobenzene and its application to a pharmacokinetic study.
Topics: Adult; Amines; Calibration; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Dinit | 2007 |
High-performance liquid chromatography/electrospray ionization ion-trap mass spectrometry for analysis of oligosaccharides derivatized by reductive amination and N,N-dimethylation.
Topics: Amination; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glucans; Humans; Methylati | 2007 |
5-Hydroxytryptamine 1A/7 and 4alpha receptors differentially prevent opioid-induced inhibition of brain stem cardiorespiratory function.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain Stem; Cardiovascular Physiological Phenomen | 2007 |
Increased dietary salt enhances sympathoexcitatory and sympathoinhibitory responses from the rostral ventrolateral medulla.
Topics: Analysis of Variance; Animals; Blood Pressure; Blood Pressure Determination; Disease Models, Animal; | 2007 |
Changes of metabolite profile in kainic acid induced hippocampal injury in rats measured by HRMAS NMR.
Topics: Amino Acids; Animals; Brain Injuries; Excitatory Amino Acid Agonists; Excitatory Amino Acids; gamma- | 2007 |
Orbitofrontal cortex function and structure in depression.
Topics: Affective Disorders, Psychotic; Animals; Depression; Frontal Lobe; gamma-Aminobutyric Acid; Humans; | 2007 |
Optimization of an HPLC method for determination of gabapentin in dosage forms through derivatization with 1-fluoro-2,4-dinitrobenzene.
Topics: Amines; Anticonvulsants; Calibration; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Ac | 2007 |
Spatial effects in the detection of gamma-aminobutyric acid: improved sensitivity at high fields using inner volume saturation.
Topics: Adult; Algorithms; Brain; gamma-Aminobutyric Acid; Humans; Image Enhancement; Image Interpretation, | 2007 |
GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors.
Topics: Animals; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Male; Neurons; | 2007 |
Simultaneous observation of glutamate, gamma-aminobutyric acid, and glutamine in human brain at 4.7 T using localized two-dimensional constant-time correlation spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Creatine; Data Interpretation, Statistical; Energy Transfer; | 2008 |
Pharmacological subtypes of the gamma-aminobutyric acidA receptors defined by a gamma-aminobutyric acid analogue 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol and allosteric coupling: characterization using subunit-specific antibodies.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Benzodiazepin | 1995 |
Selective effects of alcohols on gamma-aminobutyric acid A receptor subunits expressed in human embryonic kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Octanol; Base Sequence; Cell Line; Depression, Chem | 1994 |
Zinc is a mixed antagonist of homomeric rho 1 gamma-aminobutyric acid-activated channels.
Topics: Animals; Binding Sites; Binding, Competitive; Drug Interactions; Female; GABA Antagonists; gamma-Ami | 1995 |
An improved immunocytochemical staining method for large semi-thin plastic epon sections: application to GABA in rat cerebral cortex.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Endopeptidase K; Epoxy Resins; gamma-Aminobutyric Acid; M | 1993 |
Sub-chronic administration of ethanol to mice does not modify the inhibitory effects of dieldrin, abamectin and the dihydropyrazole RH-3421 at their respective sites of action in the nervous system.
Topics: Animals; Binding Sites; Brain; Chlorides; Dieldrin; Dose-Response Relationship, Drug; Drug Interacti | 1993 |
Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann.
Topics: Amino Acid Sequence; Animals; Brain; Cells, Cultured; gamma-Aminobutyric Acid; Heart Ventricles; In | 1994 |
Biochemical and functional identification of GABA receptors in Hydra vulgaris.
Topics: Animals; Baclofen; Bicuculline; Binding, Competitive; Diazepam; Feeding Behavior; gamma-Aminobutyric | 1995 |
Determination of gamma-aminobutyric acid levels in human cerebrospinal fluid using Pseudomonas.
Topics: Adult; Aged; Aged, 80 and over; Animals; Binding, Competitive; Brain; Buffers; Cerebrospinal Fluid; | 1995 |
Glutamate, gamma-aminobutyric acid and tachykinin-immunoreactive synapses in the cat nucleus tractus solitarii.
Topics: Animals; Cats; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Microtomy; Sensitivity | 1995 |
The SA/rABC technique: a new ABC procedure for detection of antigens at increased sensitivity.
Topics: Animals; Antibodies; Avidin; Biotin; Cerebellar Cortex; Enzyme-Linked Immunosorbent Assay; gamma-Ami | 1995 |
Alterations of GABAergic neurons in the basal ganglia of patients with progressive supranuclear palsy: an in situ hybridization study of GAD67 messenger RNA.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Autopsy; Brain; Caudate Nucleus; gamma-Aminobutyric A | 1995 |
In vivo activity of glutaminase in the brain of hyperammonaemic rats measured by 15N nuclear magnetic resonance.
Topics: Ammonia; Animals; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Glutamic Acid; Glutaminase; Gluta | 1995 |
Toxicity of four potentially ichthyotoxic marine phytoflagellates determined by four different test methods.
Topics: Animals; Artemia; Biological Assay; Brain; Eukaryota; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1994 |
Glutamate in some retinal neurons is derived solely from glia.
Topics: Animals; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Immune Sera; Immuno | 1994 |
Measurement of GABA in rat brain microdialysates using o-phthaldialdehyde-sulphite derivatization and high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dialysis; gamma-Aminobutyric Acid; H | 1994 |
U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.
Topics: Animals; Binding Sites; Cells, Cultured; Chloride Channels; Drug Interactions; gamma-Aminobutyric Ac | 1993 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; | 1993 |
Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol.
Topics: Aging; Animals; Barbiturates; Benzodiazepines; Bicuculline; Diazepam; Ethanol; GABA-A Receptor Antag | 1993 |
Involvement of gamma-aminobutyric acid in the stimulatory effect of metoclopramide on gastrointestinal motility.
Topics: Aminobutyrates; Animals; Arecoline; Bicuculline; Drug Interactions; Ethylenediamines; gamma-Aminobut | 1994 |
Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.
Topics: Benzodiazepinones; Carbolines; Cells, Cultured; DNA; Drug Synergism; Flunitrazepam; gamma-Aminobutyr | 1993 |
Pharmacological characterization of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Electric Stimulation; Evoked Potentials; Female; gam | 1995 |
Patch-clamp detection of neurotransmitters in capillary electrophoresis.
Topics: Animals; Biosensing Techniques; Electrophoresis, Capillary; gamma-Aminobutyric Acid; Glutamic Acid; | 1996 |
Kinetics of tert-[35S]butylbicyclophosphorothionate binding in the cerebral cortex of newborn and adult rats: effects of GABA and receptor desensitization.
Topics: Age Factors; Animals; Animals, Newborn; Binding Sites; Binding, Competitive; Bridged Bicyclo Compoun | 1996 |
Microcircuitry of forward and feedback connections within rat visual cortex.
Topics: Animals; Dendrites; gamma-Aminobutyric Acid; Immunohistochemistry; Interneurons; Microscopy, Electro | 1996 |
Glutamic acid decarboxylase message isoforms in human suprachiasmatic nucleus.
Topics: Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Hypothalamus; In Situ Hybridizati | 1996 |
Determination of glutamate decarboxylase by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Dose-Response Relationship, Radiation; Enzyme Induction; gamma | 1996 |
Determination of gabapentin in plasma by high-performance liquid chromatography.
Topics: Acetates; Amines; Amino Acids; Anticonvulsants; Chromatography, High Pressure Liquid; Cyclohexanecar | 1996 |
Validation of high-performance liquid chromatographic methods on two silica base-deactivated reversed phases for the determination of chloroprocaine and bupivacaine.
Topics: Anesthetics, Local; Aniline Compounds; Bupivacaine; Chromatography, High Pressure Liquid; Drug Stabi | 1996 |
The effects of 5'-N-ethylcarboxamidoadenosine on evoked release of [3H]serotonin in the rat nucleus tractus solitarius.
Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance | 1996 |
The calcineurin inhibitor cyclosporin A-cyclophilin A complex reduces desensitization of GABAA-mediated responses in acutely dissociated rat hippocampal neurons.
Topics: Animals; Calcineurin; Calmodulin-Binding Proteins; Carrier Proteins; Cyclosporine; Cyclosporins; gam | 1996 |
Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Carbolines; Diazepam; Furosemide | 1996 |
Glycine-activated whole cell and single channel currents in rat cerebellar granule cells in culture.
Topics: Animals; Cells, Cultured; Cerebellum; Chloride Channels; Drug Interactions; Electric Conductivity; E | 1997 |
In vivo vulnerability of dopamine neurons to inhibition of energy metabolism.
Topics: Animals; Axons; Corpus Striatum; Dopamine; Energy Metabolism; gamma-Aminobutyric Acid; Male; Malonat | 1997 |
Neurosteroid prolongs GABAA channel deactivation by altering kinetics of desensitized states.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Cerebellum; Desoxycorticosterone; GABA-A Receptor Agonist | 1997 |
Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment.
Topics: Alanine; Aspartic Acid; Brain; Choline; Creatine; gamma-Aminobutyric Acid; Humans; Inositol; Magneti | 1997 |
GABAergic and glycinergic IPSCs in ganglion cells of rat retinal slices.
Topics: Adaptation, Ocular; Animals; Calcium; Chlorides; gamma-Aminobutyric Acid; Glycine; Membrane Potentia | 1997 |
Measurements of human cerebral GABA at 4.1 T using numerically optimized editing pulses.
Topics: gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Occipital Lobe; Reference Values; | 1998 |
Voltage-dependent deactivation and desensitization of GABA responses in cultured murine cerebellar granule cells.
Topics: Animals; Cerebellum; Dose-Response Relationship, Drug; Electric Conductivity; Electric Stimulation; | 1998 |
Sensitive high-performance liquid chromatographic method with fluorometric detection for the simultaneous determination of gabapentin and vigabatrin in serum and urine.
Topics: Acetates; Amines; Anticonvulsants; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids | 1998 |
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cornea; Disease Models, Animal; Dizocilpine Malea | 1998 |
A high-performance liquid chromatography micromethod for the simultaneous determination of vigabatrin and gabapentin in serum.
Topics: Acetates; Amines; Anticonvulsants; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids | 1998 |
High-performance liquid chromatographic analysis of vigabatrin enantiomers in human serum by precolumn derivatization with o-phthaldialdehyde-N-acetyl-L-cysteine and fluorescence detection.
Topics: Acetylcysteine; Adolescent; Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; | 1998 |
Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat.
Topics: 4-Aminobutyrate Transaminase; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diseas | 1998 |
Rapid high-performance liquid chromatographic determination of serum gabapentin.
Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Child; Chromatography, High Pressure Liquid; C | 1999 |
Automated microanalysis of gabapentin in human serum by high-performance liquid chromatography with fluorometric detection.
Topics: Acetates; Amines; Anticonvulsants; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids | 1999 |
Off-resonance effects of the radiofrequency pulses used in spectral editing with double-quantum coherence transfer.
Topics: gamma-Aminobutyric Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Mathematics; Phantoms, Imagin | 2000 |
Single-shot, three-dimensional "non-echo" localization method for in vivo NMR spectroscopy.
Topics: Acetates; Animals; Aspartic Acid; Brain Chemistry; Calibration; Carbon Isotopes; Evaluation Studies | 2000 |
Validation of an analysis method for 4-amino-3-hydroxybutyric acid by reversed-phase liquid chromatography.
Topics: Chromatography, Liquid; gamma-Aminobutyric Acid; Pharmaceutical Preparations; Reproducibility of Res | 2000 |
Fast isocratic high-performance liquid chromatographic assay method for the simultaneous determination of gabapentin and vigabatrin in human serum.
Topics: Acetates; Amines; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Gabapentin; gam | 2000 |
Determination of the GABA(B) receptor agonist CGP 44532 (3-amino-2-hydroxypropylmethylphosphinic acid) in rat plasma after pre-column derivatization by micro-high-performance liquid chromatography combined with negative electrospray tandem mass spectromet
Topics: Animals; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Organophosphonates; Phosphin | 2000 |
A fast and sensitive method for measuring picomole levels of total free amino acids in very small amounts of biological tissues.
Topics: Amino Acids; Animals; Biochemistry; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Mercaptoethanol; | 2001 |
Rapid and sensitive step gradient assays of glutamate, glycine, taurine and gamma-aminobutyric acid by high-performance liquid chromatography-fluorescence detection with o-phthalaldehyde-mercaptoethanol derivatization with an emphasis on microdialysis sam
Topics: Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamine; Glycine; Indicators and Re | 2001 |
Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis.
Topics: Cell Line, Transformed; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; gamma-Aminobutyr | 2001 |
[The effect of gamma-aminobutyric acid injected into lateral brain ventricle of rats after prenatal cadmium intoxication on flash visual evoked potentials (FVEP)].
Topics: Animals; Cadmium; Cerebral Ventricles; Evoked Potentials, Visual; Female; gamma-Aminobutyric Acid; I | 2001 |
In vivo monitoring of amine neurotransmitters using microdialysis with on-line capillary electrophoresis.
Topics: Animals; Brain Chemistry; Dopamine; Electrophoresis, Capillary; Equipment Design; gamma-Aminobutyric | 2001 |
Unique insecticide specificity of human homomeric rho 1 GABA(C) receptor.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; gamma-Aminobutyric Acid; | 2002 |
Gabapentin for neuropathic pain following spinal cord injury.
Topics: Acetates; Acute Disease; Adolescent; Adult; Aged; Amines; Chronic Disease; Cyclohexanecarboxylic Aci | 2002 |
Enzymatic characterization of a recombinant isoform hybrid of glutamic acid decarboxylase (rGAD67/65) expressed in yeast.
Topics: Catalysis; Enzyme Stability; gamma-Aminobutyric Acid; Gene Expression; Glutamate Decarboxylase; Glut | 2002 |
Activation of protein kinase C selectively inhibits the gamma-aminobutyric acidA receptor: role of desensitization.
Topics: Animals; Brain; Chlorides; DNA; Enzyme Activation; Female; GABA-A Receptor Antagonists; gamma-Aminob | 1992 |
Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors.
Topics: Anesthetics; Animals; Barbiturates; Base Sequence; Bicuculline; Cell Line, Transformed; Cell Membran | 1992 |
Glutamate-immunoreactive synapses on retrogradely-labelled sympathetic preganglionic neurons in rat thoracic spinal cord.
Topics: Animals; Autonomic Fibers, Preganglionic; Blood Vessels; Cholera Toxin; gamma-Aminobutyric Acid; Glu | 1992 |
The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dopamine; Dr | 1992 |
Selective retrograde transport of nipecotic acid, a GABA analog, labels a subpopulation of gerbil olivocochlear neurons.
Topics: Animals; Autoradiography; Biological Transport; Cochlea; gamma-Aminobutyric Acid; Gerbillinae; Horse | 1992 |